P59220 · CALM7_ARATH
- ProteinCalmodulin-7
- GeneCAM7
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids149 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca2+ (PubMed:21419340).
Among the enzymes to be stimulated by the calmodulin-Ca2+ complex are a number of protein kinases and phosphatases (PubMed:21419340).
Activates MPK8 in vitro (PubMed:21419340).
Required during nonhost resistance (NHR) to the nonadapted fungal pathogens Phakopsora pachyrhizi and Blumeria graminis f.sp. hordei, probably via its Ca2+-dependent interaction with ABCG36 (PubMed:26315018).
Among the enzymes to be stimulated by the calmodulin-Ca2+ complex are a number of protein kinases and phosphatases (PubMed:21419340).
Activates MPK8 in vitro (PubMed:21419340).
Required during nonhost resistance (NHR) to the nonadapted fungal pathogens Phakopsora pachyrhizi and Blumeria graminis f.sp. hordei, probably via its Ca2+-dependent interaction with ABCG36 (PubMed:26315018).
Miscellaneous
This protein has four functional calcium-binding sites.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 21 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 23 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 25 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 27 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 32 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 57 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 59 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 61 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 63 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 68 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 94 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 96 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 98 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 105 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 130 | Ca2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 132 | Ca2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 134 | Ca2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 136 | Ca2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 141 | Ca2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: E |
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | nucleus | |
Cellular Component | plasma membrane | |
Molecular Function | calcium ion binding | |
Biological Process | defense response to fungus | |
Biological Process | detection of calcium ion | |
Biological Process | regulation of photomorphogenesis |
Keywords
- Ligand
Names & Taxonomy
Protein names
- Recommended nameCalmodulin-7
- Short namesCaM-7
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionP59220
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Note: Co-localizes with ABCG36 at the cytoplasm/plasma membrane interface.
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Compromised nonhost resistance (NHR) to the nonadapted fungal pathogens Phakopsora pachyrhizi and Blumeria graminis f.sp. hordei.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1 variant from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000198283 | 1-149 | Calmodulin-7 | |||
Sequence: MADQLTDDQISEFKEAFSLFDKDGDGCITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLNLMARKMKDTDSEEELKEAFRVFDKDQNGFISAAELRHVMTNLGEKLTDEEVDEMIREADVDGDGQINYEEFVKVMMAK |
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Subunit
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P59220 | At1g54610 Q9ZVM9 | 2 | EBI-1236031, EBI-1235713 | |
BINARY | P59220 | At2g26730 O48788 | 2 | EBI-1236031, EBI-1239029 | |
BINARY | P59220 | At3g02880 Q9M8T0 | 2 | EBI-1236031, EBI-1238677 | |
BINARY | P59220 | BI-1 Q9LD45 | 2 | EBI-1236031, EBI-1644586 | |
BINARY | P59220 | CIPK24 Q9LDI3 | 2 | EBI-1236031, EBI-537551 | |
BINARY | P59220 | CPK3 Q42479 | 2 | EBI-1236031, EBI-1235782 | |
BINARY | P59220 | CPK30 Q9SSF8 | 2 | EBI-1236031, EBI-1235738 | |
BINARY | P59220 | CYP71B19 Q9LTM4 | 2 | EBI-1236031, EBI-1239070 | |
BINARY | P59220 | CYP78A9 Q9SLP1 | 2 | EBI-1236031, EBI-1238437 | |
BINARY | P59220 | HSP90-2 P55737 | 2 | EBI-1236031, EBI-1235834 | |
BINARY | P59220 | psbA P83755 | 2 | EBI-1236031, EBI-1236013 | |
BINARY | P59220 | SAUR70 Q2V359 | 2 | EBI-1236031, EBI-1235819 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 8-43 | EF-hand 1 | ||||
Sequence: DQISEFKEAFSLFDKDGDGCITTKELGTVMRSLGQN | ||||||
Domain | 44-79 | EF-hand 2 | ||||
Sequence: PTEAELQDMINEVDADGNGTIDFPEFLNLMARKMKD | ||||||
Domain | 81-116 | EF-hand 3 | ||||
Sequence: DSEEELKEAFRVFDKDQNGFISAAELRHVMTNLGEK | ||||||
Domain | 117-149 | EF-hand 4 | ||||
Sequence: LTDEEVDEMIREADVDGDGQINYEEFVKVMMAK |
Sequence similarities
Belongs to the calmodulin family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length149
- Mass (Da)16,848
- Last updated2007-01-23 v2
- ChecksumEB2B188A90AD508D
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A1I9LPJ2 | A0A1I9LPJ2_ARATH | CAM7 | 214 | ||
A0A1I9LPJ1 | A0A1I9LPJ1_ARATH | CAM7 | 113 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF178073 EMBL· GenBank· DDBJ | AAD53313.1 EMBL· GenBank· DDBJ | mRNA | ||
AL162691 EMBL· GenBank· DDBJ | CAB83153.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002686 EMBL· GenBank· DDBJ | AEE77831.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY088477 EMBL· GenBank· DDBJ | AAM66013.1 EMBL· GenBank· DDBJ | mRNA |