P59220 · CALM7_ARATH

Function

function

Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca2+ (PubMed:21419340).
Among the enzymes to be stimulated by the calmodulin-Ca2+ complex are a number of protein kinases and phosphatases (PubMed:21419340).
Activates MPK8 in vitro (PubMed:21419340).
Required during nonhost resistance (NHR) to the nonadapted fungal pathogens Phakopsora pachyrhizi and Blumeria graminis f.sp. hordei, probably via its Ca2+-dependent interaction with ABCG36 (PubMed:26315018).

Miscellaneous

This protein has four functional calcium-binding sites.

Features

Showing features for binding site.

114920406080100120140
TypeIDPosition(s)Description
Binding site21Ca2+ 1 (UniProtKB | ChEBI)
Binding site23Ca2+ 1 (UniProtKB | ChEBI)
Binding site25Ca2+ 1 (UniProtKB | ChEBI)
Binding site27Ca2+ 1 (UniProtKB | ChEBI)
Binding site32Ca2+ 1 (UniProtKB | ChEBI)
Binding site57Ca2+ 2 (UniProtKB | ChEBI)
Binding site59Ca2+ 2 (UniProtKB | ChEBI)
Binding site61Ca2+ 2 (UniProtKB | ChEBI)
Binding site63Ca2+ 2 (UniProtKB | ChEBI)
Binding site68Ca2+ 2 (UniProtKB | ChEBI)
Binding site94Ca2+ 3 (UniProtKB | ChEBI)
Binding site96Ca2+ 3 (UniProtKB | ChEBI)
Binding site98Ca2+ 3 (UniProtKB | ChEBI)
Binding site105Ca2+ 3 (UniProtKB | ChEBI)
Binding site130Ca2+ 4 (UniProtKB | ChEBI)
Binding site132Ca2+ 4 (UniProtKB | ChEBI)
Binding site134Ca2+ 4 (UniProtKB | ChEBI)
Binding site136Ca2+ 4 (UniProtKB | ChEBI)
Binding site141Ca2+ 4 (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentnucleus
Cellular Componentplasma membrane
Molecular Functioncalcium ion binding
Biological Processdefense response to fungus
Biological Processdetection of calcium ion
Biological Processregulation of photomorphogenesis

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Calmodulin-7
  • Short names
    CaM-7

Gene names

    • Name
      CAM7
    • ORF names
      T28A8.100
    • Ordered locus names
      At3g43810

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    P59220

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Cell membrane
; Peripheral membrane protein
Nucleus
Note: Co-localizes with ABCG36 at the cytoplasm/plasma membrane interface.

Keywords

Phenotypes & Variants

Disruption phenotype

Compromised nonhost resistance (NHR) to the nonadapted fungal pathogens Phakopsora pachyrhizi and Blumeria graminis f.sp. hordei.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 1 variant from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001982831-149Calmodulin-7

Proteomic databases

PTM databases

Expression

Gene expression databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain8-43EF-hand 1
Domain44-79EF-hand 2
Domain81-116EF-hand 3
Domain117-149EF-hand 4

Sequence similarities

Belongs to the calmodulin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    149
  • Mass (Da)
    16,848
  • Last updated
    2007-01-23 v2
  • Checksum
    EB2B188A90AD508D
MADQLTDDQISEFKEAFSLFDKDGDGCITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLNLMARKMKDTDSEEELKEAFRVFDKDQNGFISAAELRHVMTNLGEKLTDEEVDEMIREADVDGDGQINYEEFVKVMMAK

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1I9LPJ2A0A1I9LPJ2_ARATHCAM7214
A0A1I9LPJ1A0A1I9LPJ1_ARATHCAM7113

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF178073
EMBL· GenBank· DDBJ
AAD53313.1
EMBL· GenBank· DDBJ
mRNA
AL162691
EMBL· GenBank· DDBJ
CAB83153.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002686
EMBL· GenBank· DDBJ
AEE77831.1
EMBL· GenBank· DDBJ
Genomic DNA
AY088477
EMBL· GenBank· DDBJ
AAM66013.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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