P58945 · LEUC_BUCPS
- Protein3-isopropylmalate dehydratase large subunit
- GeneleuC
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids465 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
Catalytic activity
- (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate
Cofactor
Note: Binds 1 [4Fe-4S] cluster per subunit.
Pathway
Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 347 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
Binding site | 407 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
Binding site | 410 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 3-isopropylmalate dehydratase activity | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | metal ion binding | |
Biological Process | L-leucine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name3-isopropylmalate dehydratase large subunit
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Erwiniaceae > Buchnera
Accessions
- Primary accessionP58945
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000076719 | 1-465 | 3-isopropylmalate dehydratase large subunit | ||
Interaction
Subunit
Heterodimer of LeuC and LeuD.
Structure
Sequence
- Sequence statusComplete
- Length465
- Mass (Da)52,049
- Last updated2002-08-02 v1
- Checksum23E77C44858004BD
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJ426489 EMBL· GenBank· DDBJ | CAD20139.1 EMBL· GenBank· DDBJ | Genomic DNA |