P58681 · TLR7_MOUSE

  • Protein
    Toll-like receptor 7
  • Gene
    Tlr7
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine analogs (PubMed:21402738).
Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction. In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce pro-inflammatory cytokines and interferons, respectively (By similarity) (PubMed:14976261).

Activity regulation

Activated by guanosine analogs including deoxyguanosine, 7-thia-8-oxoguanosine or 7-deazaguanosine in a RNA-independent manner.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentearly phagosome
Cellular Componentendoplasmic reticulum
Cellular Componentendoplasmic reticulum membrane
Cellular Componentendosome
Cellular Componentendosome membrane
Cellular Componentlysosome
Cellular Componentplasma membrane
Cellular Componentreceptor complex
Molecular Functiondouble-stranded RNA binding
Molecular Functionpattern recognition receptor activity
Molecular Functionsingle-stranded RNA binding
Molecular FunctionsiRNA binding
Biological Processcanonical NF-kappaB signal transduction
Biological Processcellular response to mechanical stimulus
Biological Processcellular response to virus
Biological Processdefense response to virus
Biological Processinflammatory response
Biological Processinnate immune response
Biological ProcessJNK cascade
Biological ProcessMAPK cascade
Biological Processpositive regulation of canonical NF-kappaB signal transduction
Biological Processpositive regulation of chemokine production
Biological Processpositive regulation of interferon-alpha production
Biological Processpositive regulation of interferon-beta production
Biological Processpositive regulation of interleukin-6 production
Biological Processpositive regulation of interleukin-8 production
Biological Processpositive regulation of macrophage cytokine production
Biological Processpositive regulation of non-canonical NF-kappaB signal transduction
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processpositive regulation of type II interferon production
Biological Processregulation of protein phosphorylation
Biological Processresponse to cGMP
Biological Processtoll-like receptor 7 signaling pathway
Biological Processtoll-like receptor 8 signaling pathway
Biological Processtoll-like receptor signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Toll-like receptor 7

Gene names

    • Name
      Tlr7

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P58681
  • Secondary accessions
    • Q923I1

Proteomes

Organism-specific databases

Subcellular Location

Endosome membrane
Endoplasmic reticulum membrane
; Single-pass type I membrane protein
Lysosome
Note: Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist.

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain27-837Extracellular
Transmembrane838-858Helical
Topological domain859-1050Cytoplasmic

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis264In kika; mice develop autoimmunity with splenomegaly, multiple autoantibodies, and increased total and activated B cells, germinal centers, plasma cells and memory CD4+ T cells.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 58 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Chemistry

PTM/Processing

Features

Showing features for signal, chain, glycosylation.

TypeIDPosition(s)Description
Signal1-26
ChainPRO_000003473427-1050Toll-like receptor 7
Glycosylation66N-linked (GlcNAc...) asparagine
Glycosylation69N-linked (GlcNAc...) asparagine
Glycosylation167N-linked (GlcNAc...) asparagine
Glycosylation190N-linked (GlcNAc...) asparagine
Glycosylation215N-linked (GlcNAc...) asparagine
Glycosylation387N-linked (GlcNAc...) asparagine
Glycosylation524N-linked (GlcNAc...) asparagine
Glycosylation535N-linked (GlcNAc...) asparagine
Glycosylation591N-linked (GlcNAc...) asparagine
Glycosylation680N-linked (GlcNAc...) asparagine
Glycosylation721N-linked (GlcNAc...) asparagine
Glycosylation800N-linked (GlcNAc...) asparagine

Post-translational modification

The first cleavage is performed by asparagine endopeptidase or cathepsin family members. This initial cleavage event is followed by a trimming event that is solely cathepsin mediated and required for optimal receptor signaling.

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Homodimer (By similarity).
Interacts with MYD88 via their respective TIR domains (Probable). Interacts with UNC93B1 (PubMed:17452530).
Interacts with SMPDL3B (PubMed:26095358).

Protein-protein interaction databases

Chemistry

Miscellaneous

Structure

Family & Domains

Features

Showing features for repeat, domain.

TypeIDPosition(s)Description
Repeat42-64LRR 1
Repeat65-87LRR 2
Repeat89-111LRR 3
Repeat126-149LRR 4
Repeat151-170LRR 5
Repeat171-195LRR 6
Repeat203-226LRR 7
Repeat228-247LRR 8
Repeat248-273LRR 9
Repeat275-289LRR 10
Repeat290-312LRR 11
Repeat314-337LRR 12
Repeat339-364LRR 13
Repeat369-392LRR 14
Repeat396-419LRR 15
Repeat421-443LRR 16
Repeat493-516LRR 17
Repeat517-542LRR 18
Repeat543-565LRR 19
Repeat567-589LRR 20
Repeat596-619LRR 21
Repeat620-645LRR 22
Repeat650-673LRR 23
Repeat675-698LRR 24
Repeat699-722LRR 25
Repeat724-746LRR 26
Repeat747-770LRR 27
Repeat773-796LRR 28
Domain890-1034TIR

Domain

Contains two binding domains, first site for small ligands and second site for ssRNA.

Sequence similarities

Belongs to the Toll-like receptor family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    1,050
  • Mass (Da)
    121,837
  • Last updated
    2002-01-31 v1
  • Checksum
    495B75DEE849D8EE
MVFSMWTRKRQILIFLNMLLVSRVFGFRWFPKTLPCEVKVNIPEAHVIVDCTDKHLTEIPEGIPTNTTNLTLTINHIPSISPDSFRRLNHLEEIDLRCNCVPVLLGSKANVCTKRLQIRPGSFSGLSDLKALYLDGNQLLEIPQDLPSSLHLLSLEANNIFSITKENLTELVNIETLYLGQNCYYRNPCNVSYSIEKDAFLVMRNLKVLSLKDNNVTAVPTTLPPNLLELYLYNNIIKKIQENDFNNLNELQVLDLSGNCPRCYNVPYPCTPCENNSPLQIHDNAFNSLTELKVLRLHSNSLQHVPPTWFKNMRNLQELDLSQNYLAREIEEAKFLHFLPNLVELDFSFNYELQVYHASITLPHSLSSLENLKILRVKGYVFKELKNSSLSVLHKLPRLEVLDLGTNFIKIADLNIFKHFENLKLIDLSVNKISPSEESREVGFCPNAQTSVDRHGPQVLEALHYFRYDEYARSCRFKNKEPPSFLPLNADCHIYGQTLDLSRNNIFFIKPSDFQHLSFLKCLNLSGNTIGQTLNGSELWPLRELRYLDFSNNRLDLLYSTAFEELQSLEVLDLSSNSHYFQAEGITHMLNFTKKLRLLDKLMMNDNDISTSASRTMESDSLRILEFRGNHLDVLWRAGDNRYLDFFKNLFNLEVLDISRNSLNSLPPEVFEGMPPNLKNLSLAKNGLKSFFWDRLQLLKHLEILDLSHNQLTKVPERLANCSKSLTTLILKHNQIRQLTKYFLEDALQLRYLDISSNKIQVIQKTSFPENVLNNLEMLVLHHNRFLCNCDAVWFVWWVNHTDVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNLILFSVSISSVLFLMVVMTTSHLFFWDMWYIYYFWKAKIKGYQHLQSMESCYDAFIVYDTKNSAVTEWVLQELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTQKYAKTESFKMAFYLSHQRLLDEKVDVIILIFLEKPLQKSKFLQLRKRLCRSSVLEWPANPQAHPYFWQCLKNALTTDNHVAYSQMFKETV

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A2AHJ1A2AHJ1_MOUSETlr749
A2AHJ2A2AHJ2_MOUSETlr747

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY035889
EMBL· GenBank· DDBJ
AAK62676.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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