P58474 · PEPB_HAEIN

Function

function

Probably plays an important role in intracellular peptide degradation.

Caution

Could be the product of a pseudogene.

Catalytic activity

  • Release of an N-terminal amino acid, Xaa, from a peptide or arylamide. Xaa is preferably Glu or Asp but may be other amino acids, including Leu, Met, His, Cys and Gln.
    EC:3.4.11.23 (UniProtKB | ENZYME | Rhea)

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 2 manganese ions per subunit.

Features

Showing features for binding site, active site.

143450100150200250300350400
TypeIDPosition(s)Description
Binding site198Mn2+ 2 (UniProtKB | ChEBI)
Binding site203Mn2+ 1 (UniProtKB | ChEBI)
Binding site203Mn2+ 2 (UniProtKB | ChEBI)
Active site210
Binding site221Mn2+ 2 (UniProtKB | ChEBI)
Binding site280Mn2+ 1 (UniProtKB | ChEBI)
Binding site282Mn2+ 1 (UniProtKB | ChEBI)
Binding site282Mn2+ 2 (UniProtKB | ChEBI)
Active site284

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionmanganese ion binding
Molecular Functionmetalloaminopeptidase activity
Molecular Functionpeptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Putative peptidase B
  • EC number
  • Alternative names
    • Aminopeptidase B

Gene names

    • Name
      pepB
    • Ordered locus names
      HI_0875

Organism names

Accessions

  • Primary accession
    P58474

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001658361-434Putative peptidase B

Interaction

Subunit

Homohexamer.

Structure

Family & Domains

Sequence similarities

Belongs to the peptidase M17 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    434
  • Mass (Da)
    47,285
  • Last updated
    2001-12-13 v1
  • Checksum
    A5A592E51EB18B58
MQITLSNTLANDAWGKNAILSFDSNKAMIHLKNNGKTDRTLVQQAARKLRGQGIKEVELVGEKWDLEFCWAFYQGFYTAKQDYAIEFPHLDDEPQDELLARIECGDFVRGIINEPAQSLTPVKLVERAAEFILNQADIYNEKSAVSFKIISGEELEQQGYHGIWTVGKGSANLPAMLQLDFNPTQDSNAPVLACLVGKGITFDSGGYSIKPSDGMSTMRTDMGGAALLTGALGFAIARGLNQRVKLYLCCAENLVSNNAFKLGDIITYKNGVSAEVLNTDAEGRLVLADGLIEADNQNPGFIIDCATLTGAAKSAVGNDYHSVLSMDDELVKNLFQSAQAENEPFWRLPFEDFHRSQINSSFADIANIGSVPVGAGASTATAFLSYFVKNYKQNWLHIDCSATYRKSGSDLWSVGATGIGVQTLANLMLSRSLK

Sequence caution

The sequence L42023 differs from that shown. Reason: Frameshift This may be a natural frameshift.

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
L42023
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Similar Proteins

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