P58044 · IDI1_MOUSE
- ProteinIsopentenyl-diphosphate Delta-isomerase 1
- GeneIdi1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids227 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
Catalytic activity
- isopentenyl diphosphate = dimethylallyl diphosphate
Cofactor
Note: Binds 1 Mg2+ ion per subunit.
Pathway
Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 36 | substrate | ||||
Sequence: K | ||||||
Binding site | 40 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 51 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 70 | substrate | ||||
Sequence: R | ||||||
Binding site | 74 | substrate | ||||
Sequence: K | ||||||
Active site | 86 | |||||
Sequence: C | ||||||
Binding site | 87 | substrate | ||||
Sequence: S | ||||||
Binding site | 146 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Active site | 148 | |||||
Sequence: E | ||||||
Binding site | 148 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | mitochondrion | |
Cellular Component | peroxisome | |
Molecular Function | isopentenyl-diphosphate delta-isomerase activity | |
Molecular Function | metal ion binding | |
Biological Process | cholesterol biosynthetic process | |
Biological Process | dimethylallyl diphosphate biosynthetic process | |
Biological Process | isopentenyl diphosphate biosynthetic process | |
Biological Process | response to stilbenoid |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameIsopentenyl-diphosphate Delta-isomerase 1
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionP58044
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000205225 | 1-227 | Isopentenyl-diphosphate Delta-isomerase 1 | |||
Sequence: MPEINTSHLDEKQVQLLAEMCILIDENDNKIGADTKKNCHLNENIDKGLLHRAFSVFLFNTENKLLLQQRSDAKITFPGCFTNSCCSHPLSNPGELEENNAIGVKRAAKRRLKAELGIPLEEVDLNEMDYLTRIYYKAQSDGIWGEHEVDYILFLRKNVTLNPDPNEIKSYCYVSKEEVREILKKAASGEIKLTPWFKIIADTFLFKWWDNLNHLSPFVDHEKIHRL | ||||||
Modified residue | 176 | N6-acetyllysine | ||||
Sequence: K |
Keywords
- PTM
Proteomic databases
PTM databases
Structure
Family & Domains
Features
Showing features for domain, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 49-199 | Nudix hydrolase | ||||
Sequence: LLHRAFSVFLFNTENKLLLQQRSDAKITFPGCFTNSCCSHPLSNPGELEENNAIGVKRAAKRRLKAELGIPLEEVDLNEMDYLTRIYYKAQSDGIWGEHEVDYILFLRKNVTLNPDPNEIKSYCYVSKEEVREILKKAASGEIKLTPWFKI | ||||||
Motif | 225-227 | Microbody targeting signal | ||||
Sequence: HRL |
Sequence similarities
Belongs to the IPP isomerase type 1 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length227
- Mass (Da)26,289
- Last updated2001-04-27 v1
- Checksum2B0D1176B9E328D4
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK029302 EMBL· GenBank· DDBJ | BAC26382.1 EMBL· GenBank· DDBJ | mRNA | ||
AK160832 EMBL· GenBank· DDBJ | BAE36037.1 EMBL· GenBank· DDBJ | mRNA | ||
CT010310 EMBL· GenBank· DDBJ | CAJ18518.1 EMBL· GenBank· DDBJ | mRNA | ||
BC004801 EMBL· GenBank· DDBJ | AAH04801.1 EMBL· GenBank· DDBJ | mRNA | ||
BC110313 EMBL· GenBank· DDBJ | AAI10314.1 EMBL· GenBank· DDBJ | mRNA |