P57735 · RAB25_HUMAN

  • Protein
    Ras-related protein Rab-25
  • Gene
    RAB25
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia (PubMed:17925226).
Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions (By similarity).
May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis (By similarity).

Features

Showing features for binding site.

121320406080100120140160180200
TypeIDPosition(s)Description
Binding site19-27GTP (UniProtKB | ChEBI)
Binding site67-71GTP (UniProtKB | ChEBI)
Binding site125-128GTP (UniProtKB | ChEBI)
Binding site155-157GTP (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasmic vesicle
Cellular Componentextracellular exosome
Cellular ComponentGolgi apparatus
Cellular Componentplasma membrane
Cellular Componentpseudopodium
Cellular Componentpseudopodium membrane
Cellular Componentrecycling endosome
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Molecular Functionmyosin V binding
Biological Processepithelial cell morphogenesis
Biological Processexocytosis
Biological Processpositive regulation of cell population proliferation
Biological Processpositive regulation of epithelial cell migration
Biological Processprotein transport
Biological Processpseudopodium organization
Biological Processregulation of vesicle-mediated transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ras-related protein Rab-25
  • Alternative names
    • CATX-8

Gene names

    • Name
      RAB25
    • Synonyms
      CATX8

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    P57735
  • Secondary accessions
    • Q5VYA2
    • Q8NG24
    • Q96GB1
    • Q9BT12

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Lipid-anchor
Cytoplasmic vesicle
Note: Colocalizes with integrin alpha-V/beta-1 in vesicles at the pseudopodial tips.

Keywords

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 218 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue (large scale data), lipidation, modified residue, propeptide.

TypeIDPosition(s)SourceDescription
ChainPRO_00001212151-210UniProt
Modified residue (large scale data)78PRIDEPhosphothreonine
Modified residue (large scale data)79PRIDEPhosphoserine
Modified residue (large scale data)184PRIDEPhosphoserine
Lipidation209UniProtS-geranylgeranyl cysteine
Modified residue210UniProtCysteine methyl ester
Lipidation210UniProtS-geranylgeranyl cysteine
PropeptidePRO_0000370821211-213UniProtRemoved in mature form

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in ovarian epithelium (NOE) and breast tissue. Expressed in ovarian cancer; expression is increased relative to NOE cells. Expression in ovarian cancer is stage dependent, with stage III and stage IV showing higher levels than early stage cancers. Expressed in breast cancer; expression is increased relative to normal breast tissue.

Gene expression databases

Organism-specific databases

Interaction

Subunit

Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 and RAB11FIP4. Interacts (via the hypervariable C-terminal region) with ITGB1 (via the cytoplasmic region); the interaction is GTP-dependent. Interacts with ITGAV. Associates with the integrin alpha-V/beta-1 heterodimer. Interacts with VPS33B (PubMed:28017832).

Binary interactions

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for motif.

TypeIDPosition(s)Description
Motif41-49Effector region

Sequence similarities

Belongs to the small GTPase superfamily. Rab family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    213
  • Mass (Da)
    23,496
  • Last updated
    2004-04-26 v2
  • Checksum
    119523C3036C370E
MGNGTEEDYNFVFKVVLIGESGVGKTNLLSRFTRNEFSHDSRTTIGVEFSTRTVMLGTAAVKAQIWDTAGLERYRAITSAYYRGAVGALLVFDLTKHQTYAVVERWLKELYDHAEATIVVMLVGNKSDLSQAREVPTEEARMFAENNGLLFLETSALDSTNVELAFETVLKEIFAKVSKQRQNSIRTNAITLGSAQAGQEPGPGEKRACCISL

Sequence caution

The sequence AAF98238.1 differs from that shown. Reason: Frameshift
The sequence AAM69362.1 differs from that shown. Reason: Erroneous initiation Extended N-terminus.

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict203in Ref. 1; AAF98238

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF083124
EMBL· GenBank· DDBJ
AAF98238.1
EMBL· GenBank· DDBJ
mRNA Frameshift
AF274025
EMBL· GenBank· DDBJ
AAM69362.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AL355388
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471121
EMBL· GenBank· DDBJ
EAW53003.1
EMBL· GenBank· DDBJ
Genomic DNA
BC004416
EMBL· GenBank· DDBJ
AAH04416.1
EMBL· GenBank· DDBJ
mRNA
BC009831
EMBL· GenBank· DDBJ
AAH09831.1
EMBL· GenBank· DDBJ
mRNA
BC033322
EMBL· GenBank· DDBJ
AAH33322.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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