P57367 · TRPD_BUCAI
- ProteinAnthranilate phosphoribosyltransferase
- GenetrpD
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids342 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
Catalytic activity
- N-(5-phospho-beta-D-ribosyl)anthranilate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate
Cofactor
Note: Binds 2 magnesium ions per monomer.
Pathway
Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 79 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI) | |||
Binding site | 79 | anthranilate 1 (UniProtKB | ChEBI) | |||
Binding site | 82-83 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI) | |||
Binding site | 87 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI) | |||
Binding site | 89-92 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI) | |||
Binding site | 91 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 107-115 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI) | |||
Binding site | 110 | anthranilate 1 (UniProtKB | ChEBI) | |||
Binding site | 119 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI) | |||
Binding site | 165 | anthranilate 2 (UniProtKB | ChEBI) | |||
Binding site | 223 | Mg2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 224 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 224 | Mg2+ 2 (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | anthranilate phosphoribosyltransferase activity | |
Molecular Function | magnesium ion binding | |
Biological Process | tryptophan biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAnthranilate phosphoribosyltransferase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Erwiniaceae > Buchnera
Accessions
- Primary accessionP57367
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000154434 | 1-342 | Anthranilate phosphoribosyltransferase | ||
Interaction
Structure
Sequence
- Sequence statusComplete
- Length342
- Mass (Da)38,756
- Last updated2000-12-01 v1
- Checksum9258AE148596CC24
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BA000003 EMBL· GenBank· DDBJ | BAB12990.1 EMBL· GenBank· DDBJ | Genomic DNA |