P57361 · CLSA_BUCAI
- ProteinCardiolipin synthase A
- GeneclsA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids486 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
Catalytic activity
- 2 a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + glycerol
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 224 | ||||
Active site | 226 | ||||
Active site | 231 | ||||
Active site | 404 | ||||
Active site | 406 | ||||
Active site | 411 | ||||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | cardiolipin synthase activity | |
Biological Process | cardiolipin biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCardiolipin synthase A
- EC number
- Short namesCL synthase
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Erwiniaceae > Buchnera
Accessions
- Primary accessionP57361
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 3-23 | Helical | |||
Transmembrane | 38-58 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000201249 | 1-486 | Cardiolipin synthase A | ||
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 219-246 | PLD phosphodiesterase 1 | |||
Domain | 399-426 | PLD phosphodiesterase 2 | |||
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length486
- Mass (Da)56,330
- Last updated2000-12-01 v1
- Checksum50A59BED7F6ABA56
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BA000003 EMBL· GenBank· DDBJ | BAB12983.1 EMBL· GenBank· DDBJ | Genomic DNA |