P57078 · RIPK4_HUMAN
- ProteinReceptor-interacting serine/threonine-protein kinase 4
- GeneRIPK4
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids832 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Involved in stratified epithelial development. It is a direct transcriptional target of TP63. Plays a role in NF-kappa-B activation.
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Features
Showing features for binding site, active site, site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | membrane | |
Molecular Function | ATP binding | |
Molecular Function | protein serine kinase activity | |
Molecular Function | protein serine/threonine kinase activity | |
Biological Process | morphogenesis of an epithelium | |
Biological Process | positive regulation of NF-kappaB transcription factor activity |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameReceptor-interacting serine/threonine-protein kinase 4
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionP57078
- Secondary accessions
Proteomes
Organism-specific databases
Disease & Variants
Involvement in disease
Bartsocas-Papas syndrome (BPS)
- Note
- DescriptionAn autosomal recessive disorder characterized by multiple popliteal pterygia leading to severe arthrogryposis, ankyloblepharon filiforme adnatum, filiform bands between the jaws, synostosis of the carpal/tarsal and phalangeal bones in the hands and feet, digital hypoplasia/aplasia, complete soft-tissue syndactyly, lack of nails, lack of scalp hair, eyebrows and eyelashes, blepharophimosis, cleft lip and/or palate, and hypoplastic external genitalia. Early lethality is common, although survival into childhood and beyond has been reported.
- See alsoMIM:263650
Natural variants in BPS
Variant ID | Position(s) | Change | Description | |
---|---|---|---|---|
VAR_067331 | 81 | I>N | in BPS; dbSNP:rs387906922 | |
VAR_067332 | 121 | I>N | in BPS; loss of function; dbSNP:rs387906923 | |
VAR_067333 | 184 | T>I | in BPS; loss of function | |
VAR_085697 | 189 | P>L | in BPS; uncertain significance | |
VAR_085698 | 496 | A>P | in BPS; uncertain significance | |
VAR_085699 | 666 | R>H | in BPS; uncertain significance; dbSNP:rs763794698 |
CHAND syndrome (CHANDS)
- Note
- DescriptionAn autosomal recessive syndrome characterized by ankyloblepharon, sparse, curly and woolly hair, nail dysplasia, and oral frenula.
- See alsoMIM:214350
Natural variants in CHANDS
Variant ID | Position(s) | Change | Description | |
---|---|---|---|---|
VAR_081473 | 163 | G>D | in CHANDS; uncertain significance; dbSNP:rs764278537 | |
VAR_081474 | 284 | E>K | in CHANDS; uncertain significance |
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_030160 | 12 | in dbSNP:rs6586239 | |||
Sequence: A → G | ||||||
Natural variant | VAR_067331 | 81 | in BPS; dbSNP:rs387906922 | |||
Sequence: I → N | ||||||
Natural variant | VAR_067332 | 121 | in BPS; loss of function; dbSNP:rs387906923 | |||
Sequence: I → N | ||||||
Natural variant | VAR_081473 | 163 | in CHANDS; uncertain significance; dbSNP:rs764278537 | |||
Sequence: G → D | ||||||
Natural variant | VAR_030161 | 177 | in dbSNP:rs12482626 | |||
Sequence: S → N | ||||||
Natural variant | VAR_067333 | 184 | in BPS; loss of function | |||
Sequence: T → I | ||||||
Natural variant | VAR_085697 | 189 | in BPS; uncertain significance | |||
Sequence: P → L | ||||||
Natural variant | VAR_081474 | 284 | in CHANDS; uncertain significance | |||
Sequence: E → K | ||||||
Natural variant | VAR_041050 | 462 | in dbSNP:rs55809511 | |||
Sequence: I → N | ||||||
Natural variant | VAR_041051 | 463 | in dbSNP:rs55645753 | |||
Sequence: V → M | ||||||
Natural variant | VAR_085698 | 496 | in BPS; uncertain significance | |||
Sequence: A → P | ||||||
Natural variant | VAR_041052 | 562 | in dbSNP:rs55829311 | |||
Sequence: N → Y | ||||||
Natural variant | VAR_085699 | 666 | in BPS; uncertain significance; dbSNP:rs763794698 | |||
Sequence: R → H | ||||||
Natural variant | VAR_041053 | 669 | in dbSNP:rs56056485 | |||
Sequence: R → H | ||||||
Natural variant | VAR_041054 | 749 | in dbSNP:rs35537517 | |||
Sequence: P → S |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1,106 variants from UniProt as well as other sources including ClinVar and dbSNP.
Keywords
- Disease
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for chain, cross-link, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000086613 | 1-832 | UniProt | Receptor-interacting serine/threonine-protein kinase 4 | |||
Sequence: MEGDGGTPWALALLRTFDAGEFTGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAKFRYILPVYGICREPVGLVMEYMETGSLEKLLASEPLPWDLRFRIIHETAVGMNFLHCMAPPLLHLDLKPANILLDAHYHVKISDFGLAKCNGLSHSHDLSMDGLFGTIAYLPPERIREKSRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMVKVVKGHRPELPPVCRARPRACSHLIRLMQRCWQGDPRVRPTFQGNGLNGELIRQVLAALLPVTGRWRSPGEGFRLESEVIIRVTCPLSSPQEITSETEDLCEKPDDEVKETAHDLDVKSPPEPRSEVVPARLKRASAPTFDNDYSLSELLSQLDSGVSQAVEGPEELSRSSSESKLPSSGSGKRLSGVSSVDSAFSSRGSLSLSFEREPSTSDLGTTDVQKKKLVDAIVSGDTSKLMKILQPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSLKFQGGHGPAATLLRRSKT | |||||||
Cross-link | 51 | UniProt | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) | ||||
Sequence: K | |||||||
Cross-link | 145 | UniProt | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) | ||||
Sequence: K | |||||||
Modified residue (large scale data) | 359 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 370 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 406 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 420 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 424 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 431 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 434 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 438 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 444 | PRIDE | Phosphoserine | ||||
Sequence: S |
Post-translational modification
May be phosphorylated by MAP3K2 and MAP3K3.
Proteolytically cleaved by during Fas-induced apoptosis. Cleavage at Asp-388 and Asp-426.
Polyubiquitinated with 'Lys-48' and 'Lys-63'-linked chains by BIRC2/c-IAP1 and BIRC3/c-IAP2, leading to activation of NF-kappa-B.
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Subunit
Interacts with PRKCB (By similarity).
Interacts with TRAF1, TRAF2, TRAF3 and TRAF5. Interacts with BIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4
Interacts with TRAF1, TRAF2, TRAF3 and TRAF5. Interacts with BIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P57078 | BIRC2 Q13490 | 3 | EBI-4422308, EBI-514538 | |
BINARY | P57078 | BIRC3 Q13489 | 3 | EBI-4422308, EBI-517709 | |
BINARY | P57078 | DVL2 O14641 | 4 | EBI-4422308, EBI-740850 | |
BINARY | P57078 | HIF1AN Q9NWT6 | 4 | EBI-4422308, EBI-745632 | |
BINARY | P57078 | XIAP P98170 | 2 | EBI-4422308, EBI-517127 | |
BINARY | P57078-2 | GPSM3 Q9Y4H4 | 3 | EBI-12854608, EBI-347538 | |
BINARY | P57078-2 | SPAG8 Q99932-2 | 3 | EBI-12854608, EBI-11959123 | |
BINARY | P57078-2 | VWC2L B2RUY7 | 3 | EBI-12854608, EBI-11747707 |
Protein-protein interaction databases
Chemistry
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias, repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 22-286 | Protein kinase | ||||
Sequence: FTGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAKFRYILPVYGICREPVGLVMEYMETGSLEKLLASEPLPWDLRFRIIHETAVGMNFLHCMAPPLLHLDLKPANILLDAHYHVKISDFGLAKCNGLSHSHDLSMDGLFGTIAYLPPERIREKSRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMVKVVKGHRPELPPVCRARPRACSHLIRLMQRCWQGDPRVRPTFQGNGLNGELI | ||||||
Region | 325-368 | Disordered | ||||
Sequence: QEITSETEDLCEKPDDEVKETAHDLDVKSPPEPRSEVVPARLKR | ||||||
Compositional bias | 330-355 | Basic and acidic residues | ||||
Sequence: ETEDLCEKPDDEVKETAHDLDVKSPP | ||||||
Region | 389-424 | Disordered | ||||
Sequence: SGVSQAVEGPEELSRSSSESKLPSSGSGKRLSGVSS | ||||||
Repeat | 485-514 | ANK 1 | ||||
Sequence: SGASLLHLAVEAGQEECAKWLLLNNANPNL | ||||||
Repeat | 518-547 | ANK 2 | ||||
Sequence: RGSTPLHMAVERRVRGVVELLLARKISVNA | ||||||
Repeat | 551-580 | ANK 3 | ||||
Sequence: DQWTALHFAAQNGDESSTRLLLEKNASVNE | ||||||
Repeat | 584-613 | ANK 4 | ||||
Sequence: EGRTPMHVACQHGQENIVRILLRRGVDVSL | ||||||
Repeat | 617-647 | ANK 5 | ||||
Sequence: DAWLPLHYAAWQGHLPIVKLLAKQPGVSVNA | ||||||
Repeat | 651-680 | ANK 6 | ||||
Sequence: DGRTPLHLAAQRGHYRVARILIDLCSDVNV | ||||||
Repeat | 684-713 | ANK 7 | ||||
Sequence: LAQTPLHVAAETGHTSTARLLLHRGAGKEA | ||||||
Repeat | 717-746 | ANK 8 | ||||
Sequence: DGYTALHLAARNGHLATVKLLVEEKADVLA | ||||||
Repeat | 750-780 | ANK 9 | ||||
Sequence: LNQTALHLAAAHGHSEVVEELVSADVIDLFD | ||||||
Repeat | 782-811 | ANK 10 | ||||
Sequence: QGLSALHLAAQGRHAQTVETLLRHGAHINL |
Sequence similarities
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
P57078-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length832
- Mass (Da)91,611
- Last updated2000-12-01 v1
- Checksum5D8FFFD5F04F7ECB
P57078-2
- Name2
- Differences from canonical
- 278-325: Missing
Features
Showing features for alternative sequence, compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_004862 | 278-325 | in isoform 2 | |||
Sequence: Missing | ||||||
Compositional bias | 330-355 | Basic and acidic residues | ||||
Sequence: ETEDLCEKPDDEVKETAHDLDVKSPP | ||||||
Sequence conflict | 714 | in Ref. 1; BAB56136 | ||||
Sequence: M → V |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB047783 EMBL· GenBank· DDBJ | BAB56136.1 EMBL· GenBank· DDBJ | mRNA | ||
AP001743 EMBL· GenBank· DDBJ | BAA95526.1 EMBL· GenBank· DDBJ | Genomic DNA |