P56986 · GALE_NEIMC
- ProteinUDP-glucose 4-epimerase
- GenegalE
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids339 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in the metabolism of galactose. Plays an essential role in the incorporation of galactose into meningococcal lipopolysaccharide surface molecules, which are important for pathogenesis. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD.
Catalytic activity
- UDP-alpha-D-glucose = UDP-alpha-D-galactose
Cofactor
Pathway
Carbohydrate metabolism; galactose metabolism.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 12-13 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 32-37 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 59-60 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 81-85 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 100 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 125 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 125 | substrate | |||
Active site | 150 | Proton acceptor | |||
Binding site | 150 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 150 | substrate | |||
Binding site | 154 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 179 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 180 | substrate | |||
Binding site | 200-201 | substrate | |||
Binding site | 217-219 | substrate | |||
Binding site | 232 | substrate | |||
Binding site | 293-296 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | UDP-glucose 4-epimerase activity | |
Biological Process | galactose catabolic process via UDP-galactose |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUDP-glucose 4-epimerase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Neisseriales > Neisseriaceae > Neisseria
Accessions
- Primary accessionP56986
- Secondary accessions
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000183214 | 1-339 | UDP-glucose 4-epimerase | ||
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Length339
- Mass (Da)37,030
- Last updated2000-12-01 v1
- MD5 ChecksumF47628AB2AA802C876CAA735C245232D
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U19895 EMBL· GenBank· DDBJ | AAA86716.1 EMBL· GenBank· DDBJ | Genomic DNA |