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P56986 · GALE_NEIMC

Function

function

Involved in the metabolism of galactose. Plays an essential role in the incorporation of galactose into meningococcal lipopolysaccharide surface molecules, which are important for pathogenesis. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD.

Catalytic activity

Cofactor

NAD+ (UniProtKB | Rhea| CHEBI:57540 )

Pathway

Carbohydrate metabolism; galactose metabolism.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site12-13NAD+ (UniProtKB | ChEBI)
Binding site32-37NAD+ (UniProtKB | ChEBI)
Binding site59-60NAD+ (UniProtKB | ChEBI)
Binding site81-85NAD+ (UniProtKB | ChEBI)
Binding site100NAD+ (UniProtKB | ChEBI)
Binding site125NAD+ (UniProtKB | ChEBI)
Binding site125substrate
Active site150Proton acceptor
Binding site150NAD+ (UniProtKB | ChEBI)
Binding site150substrate
Binding site154NAD+ (UniProtKB | ChEBI)
Binding site179NAD+ (UniProtKB | ChEBI)
Binding site180substrate
Binding site200-201substrate
Binding site217-219substrate
Binding site232substrate
Binding site293-296substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionUDP-glucose 4-epimerase activity
Biological Processgalactose catabolic process via UDP-galactose

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    UDP-glucose 4-epimerase
  • EC number
  • Alternative names
    • Galactowaldenase
    • UDP-galactose 4-epimerase

Gene names

    • Name
      galE

Organism names

Accessions

  • Primary accession
    P56986
  • Secondary accessions
    • Q59617
    • Q59624

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001832141-339UDP-glucose 4-epimerase

Interaction

Subunit

Homodimer.

Structure

Family & Domains

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    339
  • Mass (Da)
    37,030
  • Last updated
    2000-12-01 v1
  • MD5 Checksum
    F47628AB2AA802C876CAA735C245232D
MKKILVTGGTGFIGSHTVVSLLKSGHQVVILDNLCNSSINILPRLKTITGQEIPFYQGDIRDREILRRIFAENRIDSVIHFAGLKAVGESVAEPMKYYDNNVSGSLVLAEEMARAGVFKIVFSSSATVYGDPGKVPYTEDMQPGDTTSPYGTSKSMVERILSDIQKADPRWSVILLRYFNPIGAHESGLIGEQPNGIPNNLLPYICQVAAGKLPQLAVFGGDYPTPDGTGMRDYIHVMDLAEGHVAAMQAKSNVAGTHLLNLGSGRASSVLEIIRAFEAASGLTIPYEVKPRRAGDLACFYADPSYAKAQIGWQTQRDLTQMMEDSWRWVSNNPNGYDD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U19895
EMBL· GenBank· DDBJ
AAA86716.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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