P56913 · NUOF2_RHIME
- ProteinNADH-quinone oxidoreductase subunit F 2
- GenenuoF2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids421 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
Catalytic activity
- a quinone + NADH + 5 H+(in) = a quinol + NAD+ + 4 H+(out)
CHEBI:132124 + CHEBI:57945 + 5 H+ (in)CHEBI:15378= CHEBI:24646 + CHEBI:57540 + 4 H+ (out)CHEBI:15378
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 FMN.
Note: Binds 1 [4Fe-4S] cluster.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 53-62 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 165-212 | FMN (UniProtKB | ChEBI) | |||
Binding site | 342 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
Binding site | 345 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
Binding site | 348 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
Binding site | 388 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | respiratory chain complex I | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | FMN binding | |
Molecular Function | metal ion binding | |
Molecular Function | NAD binding | |
Molecular Function | NADH dehydrogenase (ubiquinone) activity | |
Molecular Function | quinone binding |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNADH-quinone oxidoreductase subunit F 2
- EC number
- Alternative names
Gene names
Encoded on
- Plasmid pSymA (megaplasmid 1)
Organism names
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Rhizobiaceae > Sinorhizobium/Ensifer group > Sinorhizobium
Accessions
- Primary accessionP56913
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000118577 | 1-421 | NADH-quinone oxidoreductase subunit F 2 | ||
Keywords
- PTM
Structure
Sequence
- Sequence statusComplete
- Length421
- Mass (Da)45,504
- Last updated2001-11-02 v2
- MD5 Checksum565731CDD82F5389C5F8E628F874833F
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Sequence conflict | 149 | in Ref. 1; CAB51634 | |||
Sequence conflict | 155 | in Ref. 1; CAB51634 | |||
Sequence conflict | 407 | in Ref. 1; CAB51634 | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJ245399 EMBL· GenBank· DDBJ | CAB51634.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE006469 EMBL· GenBank· DDBJ | AAK65487.1 EMBL· GenBank· DDBJ | Genomic DNA |