P56911 · NUON2_RHIME

Function

function

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular FunctionNADH dehydrogenase (ubiquinone) activity
Molecular FunctionNADH:ubiquinone reductase (non-electrogenic) activity
Molecular Functionquinone binding
Biological ProcessATP synthesis coupled electron transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH-quinone oxidoreductase subunit N 2
  • EC number
  • Alternative names
    • NADH dehydrogenase I subunit N 2
    • NDH-1 subunit N 2

Gene names

    • Name
      nuoN2
    • ORF names
      SMa1535
    • Ordered locus names
      RA0835

Encoded on

  • Plasmid pSymA (megaplasmid 1)

Organism names

Accessions

  • Primary accession
    P56911

Proteomes

Subcellular Location

Cell inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane9-29Helical
Transmembrane40-60Helical
Transmembrane75-95Helical
Transmembrane110-130Helical
Transmembrane131-151Helical
Transmembrane164-184Helical
Transmembrane206-226Helical
Transmembrane238-258Helical
Transmembrane272-292Helical
Transmembrane299-319Helical
Transmembrane326-346Helical
Transmembrane371-391Helical
Transmembrane404-424Helical
Transmembrane449-469Helical

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001176951-479NADH-quinone oxidoreductase subunit N 2

Keywords

Interaction

Subunit

NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.

Structure

Family & Domains

Sequence similarities

Belongs to the complex I subunit 2 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    479
  • Mass (Da)
    51,478
  • Last updated
    2001-10-24 v3
  • MD5 Checksum
    63288C0851E55768ED1092371272F479
MTAAALLQWALASVPEIIVVTGACVLLIVGELVRKGRDDLLLWASVAIVLLAAVATLMLAGEMRPAYAGMFISDRFAVFFKLVFYLATILTFFLSRKYAEIEGIGRSEYYVLLLFALVGMMIMASAIDLLSIYVGLELMVLCTYVLTGFLRKERRSNEAALKYVILGAVSTAIFLYGVSLIYGLTGTTQLDRMAEAVSGGPLDPALLLAVVFIVAGLVFKIGAVPFHMWVPDVYEGAPTTITAFMSVAPKAAGFAVILRVFLNPLVEASNAWIIVAAIAVATMALGSFVALVQDNFKRLLAYSSIAHAGFAIFGVVAGGQDGIASVMLYLLIYTFMNLGIFGAVIMMRNGDFSGEVIEDYAGFAKFHPGLALLMLLYLFSLAGIPPTAGFFAKFYVLVALVERGFVALAVIAVLLSVVSAYFYIRIVMVIYMREPERAFEPALTPLVSATLAFTAAGTIGIGLFPAWFLRLAQQSAFGG

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict14in Ref. 1; CAB51628

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ245399
EMBL· GenBank· DDBJ
CAB51628.2
EMBL· GenBank· DDBJ
Genomic DNA
AE006469
EMBL· GenBank· DDBJ
AAK65493.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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