P56703 · WNT3_HUMAN

  • Protein
    Proto-oncogene Wnt-3
  • Gene
    WNT3
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:26902720).
Required for normal gastrulation, formation of the primitive streak, and for the formation of the mesoderm during early embryogenesis. Required for normal formation of the apical ectodermal ridge (By similarity).
Required for normal embryonic development, and especially for limb development (PubMed:14872406).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendocytic vesicle membrane
Cellular Componentendoplasmic reticulum lumen
Cellular Componentextracellular exosome
Cellular Componentextracellular matrix
Cellular Componentextracellular region
Cellular Componentextracellular space
Cellular ComponentGolgi lumen
Cellular Componentplasma membrane
Cellular ComponentWnt signalosome
Molecular Functioncytokine activity
Molecular Functionfrizzled binding
Molecular Functionprotein domain specific binding
Molecular Functionreceptor ligand activity
Biological Processanterior/posterior axis specification
Biological Processaxon guidance
Biological Processcanonical Wnt signaling pathway
Biological Processcanonical Wnt signaling pathway involved in mesenchymal stem cell differentiation
Biological Processcell fate commitment
Biological Processcell morphogenesis
Biological Processcellular response to retinoic acid
Biological Processdorsal/ventral axis specification
Biological Processembryonic forelimb morphogenesis
Biological Processembryonic hindlimb morphogenesis
Biological Processgamete generation
Biological Processgene expression
Biological Processhead morphogenesis
Biological Processlimb bud formation
Biological Processmammary gland epithelium development
Biological Processmesoderm formation
Biological Processmidbrain dopaminergic neuron differentiation
Biological Processnegative regulation of axon extension involved in axon guidance
Biological Processneuron differentiation
Biological Processpositive regulation of collateral sprouting in absence of injury
Biological Processpositive regulation of gene expression
Biological Processpositive regulation of osteoblast differentiation
Biological Processpositive regulation of Wnt signaling pathway
Biological Processregulation of mesenchymal stem cell differentiation
Biological Processregulation of neurogenesis
Biological ProcessSpemann organizer formation at the anterior end of the primitive streak
Biological Processstem cell proliferation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Proto-oncogene Wnt-3
  • Alternative names
    • Proto-oncogene Int-4 homolog

Gene names

    • Name
      WNT3
    • Synonyms
      INT4

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    P56703
  • Secondary accessions
    • Q2M237
    • Q9H1J9

Proteomes

Organism-specific databases

Disease & Variants

Involvement in disease

Tetraamelia syndrome 1 (TETAMS1)

  • Note
    • The disease is caused by variants affecting the gene represented in this entry
  • Description
    A form of tetraamelia, a rare disease characterized by rudimentary appendages or complete absence of all four limbs, and other anomalies such as craniofacial, nervous system, pulmonary, skeletal and urogenital defects. TETAMS1 patients manifest complete limb agenesis without defects of scapulae or clavicles. Other features include bilateral cleft lip/palate, diaphragmatic defect with bilobar right lung, renal and adrenal agenesis, pelvic hypoplasia, and urogenital defects. TETAMS1 transmission pattern is consistent with autosomal recessive inheritance.
  • See also
    MIM:273395

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 537 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Keywords

Organism-specific databases

Miscellaneous

Chemistry

Genetic variation databases

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation, lipidation.

TypeIDPosition(s)Description
Signal1-21
ChainPRO_000004141622-355Proto-oncogene Wnt-3
Disulfide bond80↔91
Glycosylation90N-linked (GlcNAc...) asparagine
Disulfide bond131↔139
Disulfide bond141↔158
Disulfide bond206↔220
Disulfide bond208↔215
Lipidation212O-palmitoleoyl serine; by PORCN
Disulfide bond284↔315
Disulfide bond300↔310
Glycosylation301N-linked (GlcNAc...) asparagine
Disulfide bond314↔354
Disulfide bond330↔345
Disulfide bond332↔342
Disulfide bond337↔338

Post-translational modification

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Subunit

Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity (PubMed:26902720).
The complex with AFM may represent the physiological form in body fluids (PubMed:26902720).
Interacts with PORCN. Interacts with WLS (By similarity).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY P56703AFM P436523EBI-3644922, EBI-20737924
BINARY P56703FZD7 O750843EBI-3644922, EBI-746917
XENO P56703Fzd8 Q610912EBI-3644922, EBI-6171689

Protein-protein interaction databases

Chemistry

Miscellaneous

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    355
  • Mass (Da)
    39,645
  • Last updated
    2001-06-20 v2
  • Checksum
    85D15F2C7884A64F
MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A9L9PXI5A0A9L9PXI5_HUMANWNT3170
A0A9L9PXJ3A0A9L9PXJ3_HUMANWNT3290
A0A9L9PXK4A0A9L9PXK4_HUMANWNT367

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY009397
EMBL· GenBank· DDBJ
AAG38657.1
EMBL· GenBank· DDBJ
mRNA
AB067628
EMBL· GenBank· DDBJ
BAB70502.1
EMBL· GenBank· DDBJ
mRNA
BC112116
EMBL· GenBank· DDBJ
AAI12117.1
EMBL· GenBank· DDBJ
mRNA
BC112118
EMBL· GenBank· DDBJ
AAI12119.1
EMBL· GenBank· DDBJ
mRNA
BC114219
EMBL· GenBank· DDBJ
AAI14220.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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