P56602 · PPOX_BOVIN
- ProteinProtoporphyrinogen oxidase
- GenePPOX
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids477 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
Catalytic activity
- 3 O2 + protoporphyrinogen IX = 3 H2O2 + protoporphyrin IX
Cofactor
Note: Binds 1 FAD per subunit.
Pathway
Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 9-14 | FAD (UniProtKB | ChEBI) | ||||
Sequence: GGGISG | ||||||
Binding site | 34-35 | FAD (UniProtKB | ChEBI) | ||||
Sequence: EG | ||||||
Binding site | 42 | FAD (UniProtKB | ChEBI) | ||||
Sequence: W | ||||||
Binding site | 57-60 | FAD (UniProtKB | ChEBI) | ||||
Sequence: GPRG | ||||||
Binding site | 257 | FAD (UniProtKB | ChEBI) | ||||
Sequence: V | ||||||
Binding site | 449 | FAD (UniProtKB | ChEBI) | ||||
Sequence: A | ||||||
Binding site | 454-456 | FAD (UniProtKB | ChEBI) | ||||
Sequence: VAV |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | mitochondrial intermembrane space | |
Molecular Function | oxygen-dependent protoporphyrinogen oxidase activity | |
Biological Process | heme A biosynthetic process | |
Biological Process | heme B biosynthetic process | |
Biological Process | heme biosynthetic process | |
Biological Process | heme O biosynthetic process | |
Biological Process | protoporphyrinogen IX biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtoporphyrinogen oxidase
- EC number
- Short namesPPO
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos
Accessions
- Primary accessionP56602
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Peripheral membrane protein
Note: Bound to the mitochondrial inner membrane with its active site facing the cytosolic side.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000135269 | 1-477 | Protoporphyrinogen oxidase | |||
Sequence: MGRTVVVLGGGISGLAASYYLSRAPCPPKVVLVEGSERLGGWIRSVRGPDGAIFELGPRGIRPAGALGARTLLLVSELGLDSEVLPVRGDHPAAQNRFLYVGGALHALPSGIRGLLRPSPPFSKPLFWAGLRDLTTPRGKDPDETVHSFAQRRLGPEVASLAMDSLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSILLGLLLGAGRGPQLDSALIRQAQAERWSQWSLRGGLETLPQALHAHLTSRGVSVLQGQPVCGLSLQAEGRWKVSLEDSSLEADHIISAIPASVLSKLLPAEATPLARALSTITAVSVAVVNLQYRGARLPVQGFGHLVPSSEDPVILGIVYDSVAFPEQDGSLPGLRLTVMLGGSWLQTLEARGCVLSQELLQQEAEKAAATQLGLNEPPSHCLVHLHKNSIPQYTLGHWQKLESAAQFLAAQKLPLTLAGASYEGVAVNDCIESGRQAAARVLGTEPNS |
Proteomic databases
Expression
Interaction
Structure
Sequence
- Sequence statusComplete
- Length477
- Mass (Da)50,612
- Last updated2014-02-19 v2
- ChecksumE2A4581893001BEB
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0AAA9SKP2 | A0AAA9SKP2_BOVIN | PPOX | 185 | ||
A0AAA9SPA7 | A0AAA9SPA7_BOVIN | PPOX | 140 | ||
A0AAA9TN09 | A0AAA9TN09_BOVIN | PPOX | 433 | ||
A0AAA9TVH7 | A0AAA9TVH7_BOVIN | PPOX | 195 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DAAA02006959 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |