P56541 · DNS2A_BOVIN

  • Protein
    Deoxyribonuclease-2-alpha
  • Gene
    DNASE2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

function

Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the clearance of nucleic acids generated through apoptosis, hence preventing autoinflammation. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver and bone marrow, where it degrades nuclear DNA expelled from erythroid precursor cells.

Catalytic activity

  • Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotide end-products.
    EC:3.1.22.1 (UniProtKB | ENZYME | Rhea)

Features

Showing features for active site.

136550100150200250300350
TypeIDPosition(s)Description
Active site298

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentlysosome
Molecular Functiondeoxyribonuclease II activity
Biological Processapoptotic DNA fragmentation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Deoxyribonuclease-2-alpha
  • EC number
  • Alternative names
    • Acid DNase
    • Deoxyribonuclease II alpha (DNase II alpha)
    • Lysosomal DNase II

Gene names

    • Name
      DNASE2
    • Synonyms
      DNASE2A, DNL2

Organism names

  • Taxonomic identifier
  • Strain
    • Hereford
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    P56541
  • Secondary accessions
    • O46614
    • Q17QD1

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation.

Type
IDPosition(s)Description
Signal1-19
ChainPRO_000014510020-365Deoxyribonuclease-2-alpha
Disulfide bond22↔162
Glycosylation215N-linked (GlcNAc...) asparagine
Glycosylation269N-linked (GlcNAc...) asparagine
Disulfide bond270↔348
Glycosylation293N-linked (GlcNAc...) asparagine
Disulfide bond311↔330

Keywords

Proteomic databases

PTM databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the DNase II family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    365
  • Mass (Da)
    40,282
  • Last updated
    2006-10-17 v2
  • Checksum
    B9B6219E51448622
MATLSSLLLTALLWVPVGTLTCYGDSGQPVDWFVVYKLPAHTGSGDATQNGLRYKYFDEHSEDWSDGVGFINSTTGAVGRSLLPLYRNNNSQLAFVLYNDQPPKSSESKDSSSRGHTKGVLLLDQEGGFWLIHSVPNFPPRASSAVYSWPPGAQKYGQTLICVSFPLTQFLDISKQLTYTYPLVYDHRLEGDFAQKFPYLEEVVKGHHVRQGPWNSSVTLTSKKGATFQSFAKFGNFGDDLYSGWLSEALGSTLQVQFWQRSSGILPSNCSGAQHVFDVTQTAFPGPAGPAFNATEDHSKWCVTPKGPWACVGDMNRNQREEHRGGGTLCAQMLWKAFKPLVKAWEPCEKKSRAYSLGSPAGLWT

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict146in Ref. 2; AAC77367
Sequence conflict194in Ref. 2; AAC77367
Sequence conflict247in Ref. 2; AAC77367

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC118429
EMBL· GenBank· DDBJ
AAI18430.1
EMBL· GenBank· DDBJ
mRNA
AF047017
EMBL· GenBank· DDBJ
AAC77367.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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