P56476 · GBRR2_MOUSE

  • Protein
    Gamma-aminobutyric acid receptor subunit rho-2
  • Gene
    Gabrr2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Rho subunit of the pentameric ligand-gated chloride channels responsible for mediating the effects of gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain (By similarity).
Rho-containing GABA-gated chloride channels are a subclass of GABA(A) receptors (GABAARs) entirely composed of rho subunits, where GABA molecules bind at the rho intersubunit interfaces (By similarity).
When activated by GABA, rho-GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity).
Rho-2 GABAARs may contribute to the regulation of glial development in the cerebellum by controlling extrasynaptic transmission (PubMed:25422464).
Rho-2 GABAARs are also involved in neuronal tonic (extrasynaptic) and phasic (synaptic) transmission in the Purkinje neurons of the cerebellum (PubMed:16945976).
Rho-2 GABAARs expressed in retina may play a role in retinal neurotransmission (By similarity).

Catalytic activity

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site1054-aminobutanoate (UniProtKB | ChEBI); ligand shared between two neighboring rho subunits; in chain A
Binding site1694-aminobutanoate (UniProtKB | ChEBI); ligand shared between two neighboring rho subunits; in chain A
Binding site1974-aminobutanoate (UniProtKB | ChEBI); ligand shared between two neighboring rho subunits; in chain B

GO annotations

AspectTerm
Cellular Componentaxon
Cellular Componentchloride channel complex
Cellular ComponentGABA-A receptor complex
Cellular ComponentGABA-ergic synapse
Cellular Componentneuron projection
Cellular Componentplasma membrane
Cellular Componentpostsynaptic membrane
Cellular Componentsynapse
Cellular Componenttransmembrane transporter complex
Molecular FunctionGABA-A receptor activity
Molecular FunctionGABA-gated chloride ion channel activity
Molecular Functionneurotransmitter receptor activity
Molecular Functionprotein domain specific binding
Molecular Functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
Biological Processchloride transmembrane transport
Biological Processchloride transport
Biological Processgamma-aminobutyric acid signaling pathway
Biological Processvisual perception

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Gamma-aminobutyric acid receptor subunit rho-2
  • Alternative names
    • GABA(A) receptor subunit rho-2 (GABAAR subunit rho-2)
    • GABA(C) receptor

Gene names

    • Name
      Gabrr2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P56476
  • Secondary accessions
    • Q6PEP0

Proteomes

Organism-specific databases

Subcellular Location

Postsynaptic cell membrane
; Multi-pass membrane protein
Cell membrane
; Multi-pass membrane protein
Note: Located at the plasma membrane of astrocytes, in soma and to some extent in distal processes.

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain21-260Extracellular
Transmembrane261-281Helical
Topological domain282-293Cytoplasmic
Transmembrane294-314Helical
Topological domain315-325Extracellular
Transmembrane326-346Helical
Topological domain347-443Cytoplasmic
Transmembrane444-464Helical
Topological domain465Extracellular

Keywords

PTM/Processing

Features

Showing features for signal, chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
Signal1-20
ChainPRO_000000048921-465Gamma-aminobutyric acid receptor subunit rho-2
Glycosylation120N-linked (GlcNAc...) asparagine
Disulfide bond178↔192
Glycosylation254N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in the cerebellum.

Developmental stage

Expressed during early postnatal development of cerebellar ependymal glial cells. The expression is down-regulated in young mice, but limited to Purkinje neurons and a small fraction of glial cells in adults.

Gene expression databases

Interaction

Subunit

Three rho subunits (rho-1/GBRR1, rho-2/GBRR2 and rho-3/GBRR3) coassemble either to form functional homopentamers or heteropentamers (PubMed:25422464).
Rho-2 is unable to form a functional homopentamer (By similarity).
Interacts with SQSTM1 (By similarity).

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Domain

GABAARs subunits share a common topological structure: a peptide sequence made up of a long extracellular N-terminal, four transmembrane domains, intracellular or cytoplasmic domain located between the third and the fourth transmembrane domains.

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 2 isoforms produced by Alternative initiation.

P56476-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    465
  • Mass (Da)
    54,231
  • Last updated
    2012-10-31 v4
  • Checksum
    B44B51B572468A20
MPYLMRLALVLFCLMALVESRKPRRKRWTGLLETSKPSHLYKKNLDVTKMRPGKPRPLLRVEDHDFTMRPAFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWRDERLAFPSSSNKSMTFDGRLVKKIWVPDVFFVHSKRSFIHDTTTDNIMLRVFPDGHVLYSMRITVTAMCNMDFSHFPLDSQTCSLELESYAYTDEDLMLYWKNGDESLKTDEKISLSQFLIQKFHTTSRLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDHRAVPARVSLGIMTVLTMSTIITGVNASMPRVSYIRAVDIYLWVSFVFVFLSVLEYAAVNYLTTLQEQKERKFREKLPCMCGMLHSRTMMLDGSYSESEANSLAGYPRSHILPEEERPDNIVVHLALNSELTSSRKKGLLKGQMGLYIFQNTHAIDKYSRLIFPAFYIVFNLIYWSVFS

P56476-2

  • Name
    2
  • Note
    Isoform 2 could be translated from an upstream initiator ATG located in frame within the first coding exon. The probability of a signal peptide within this isoform is very low.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-1: M → MVKPGGILPIKSPCTAACCIIDMCRM

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
F6YZH6F6YZH6_MOUSEGabrr2221
A3KG54A3KG54_MOUSEGabrr2203

Features

Showing features for alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_0443741in isoform 2
Sequence conflict33in Ref. 1; AAB81965
Sequence conflict52in Ref. 1; AAB81965
Sequence conflict59in Ref. 1; AAB81965
Sequence conflict88in Ref. 1; AAB81965
Sequence conflict105in Ref. 1; AAB81965
Sequence conflict109in Ref. 1; AAB81965
Sequence conflict149in Ref. 1; AAB81965
Sequence conflict357in Ref. 1; AAB81965
Sequence conflict366in Ref. 1; AAB81965
Sequence conflict372in Ref. 1; AAB81965
Sequence conflict394in Ref. 1; AAB81965
Sequence conflict400in Ref. 1; AAB81965
Sequence conflict421in Ref. 1; AAB81965
Sequence conflict429in Ref. 1; AAB81965

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF024621
EMBL· GenBank· DDBJ
AAB81965.1
EMBL· GenBank· DDBJ
mRNA
CH466538
EMBL· GenBank· DDBJ
EDL05492.1
EMBL· GenBank· DDBJ
Genomic DNA
BC057957
EMBL· GenBank· DDBJ
AAH57957.2
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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