P55989 · COPA_HELPY
- ProteinCopper-transporting ATPase
- GenecopA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids745 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Probably involved in copper export.
Catalytic activity
- Cu2+(in) + ATP + H2O = Cu2+(out) + ADP + phosphate + H+Cu2+ (in)CHEBI:29036
+ CHEBI:30616 + CHEBI:15377 = Cu2+ (out)CHEBI:29036+ CHEBI:456216 + CHEBI:43474 + CHEBI:15378
Features
Showing features for binding site, active site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | copper ion binding | |
Molecular Function | P-type divalent copper transporter activity | |
Biological Process | copper ion homeostasis |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCopper-transporting ATPase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Campylobacterota > Epsilonproteobacteria > Campylobacterales > Helicobacteraceae > Helicobacter
Accessions
- Primary accessionP55989
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-83 | Cytoplasmic | ||||
Sequence: MKESFYIEGMTCTACSSGIERSLGRKSFVKKIEVSLLNKSANIEFDENQTNLDEIFKLIEKLGYSPKKALTKEKKEFFSPNVK | ||||||
Transmembrane | 84-104 | Helical | ||||
Sequence: LALAVIFTLFVVYLSMGAMLS | ||||||
Topological domain | 105-124 | Extracellular | ||||
Sequence: PSLLPESLLAIDNHSNFLNA | ||||||
Transmembrane | 125-144 | Helical | ||||
Sequence: CLQLIGALIVMHLGRDFYIQ | ||||||
Topological domain | 145-151 | Cytoplasmic | ||||
Sequence: GFKALWH | ||||||
Transmembrane | 152-172 | Helical | ||||
Sequence: RQPNMSSLIAIGTSAALISSL | ||||||
Topological domain | 173-194 | Extracellular | ||||
Sequence: WQLYLVYTNHYTDQWSYGHYYF | ||||||
Transmembrane | 195-215 | Helical | ||||
Sequence: ESVCVILMFVMVGKRIENVSK | ||||||
Topological domain | 216-343 | Cytoplasmic | ||||
Sequence: DKALDAMQALMKNAPKTALKMQNNQQIEVLVDSIVVGDILKVLPGSAIAVDGEIIEGEGELDESMLSGEALPVYKKVGDKVFSGTFNSHTSFLMKATQNNKNSTLSQIIEMIYNAQSSKAEISRLADK | ||||||
Transmembrane | 344-366 | Helical | ||||
Sequence: VSSVFVPSVIAISILAFVVWLII | ||||||
Topological domain | 367-379 | Extracellular | ||||
Sequence: APKPDFWWNFGIA | ||||||
Transmembrane | 380-397 | Helical | ||||
Sequence: LEVFVSVLVISCPCALGL | ||||||
Topological domain | 398-685 | Cytoplasmic | ||||
Sequence: ATPMSILVANQKASSLGLFFKDAKSLEKARLVNTIVFDKTGTLTNGKPVVKSVHSKIELLELLSLALSIEKSSEHVIAKGIVEYAKEHNAPLKEMSGVKVKTGFGISAKTDYQGTKEIIKVGNSEFFNPINTLEIKENGILVFVGRAISEKEDELLGAFVLEDLPKKGVKEHIAQIKNLGINTFLLSGDNRENVQKCAFELGIDGYISNAKPQDKLNKIKELKEKGQIVMMVGDGLNDAPSLAMSDVAVVMAKGSDVSVQAADIVSFNNDIKSVYSAIKLSQATIKNI | ||||||
Transmembrane | 686-705 | Helical | ||||
Sequence: KENLFWAFCYNSVFIPLACG | ||||||
Topological domain | 706-716 | Extracellular | ||||
Sequence: VLYKANLMLSP | ||||||
Transmembrane | 717-735 | Helical | ||||
Sequence: AIAGLAMSLSSVSVVLNSQ | ||||||
Topological domain | 736-745 | Cytoplasmic | ||||
Sequence: RLRNFKIKDH |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000046170 | 1-745 | Copper-transporting ATPase | |||
Sequence: MKESFYIEGMTCTACSSGIERSLGRKSFVKKIEVSLLNKSANIEFDENQTNLDEIFKLIEKLGYSPKKALTKEKKEFFSPNVKLALAVIFTLFVVYLSMGAMLSPSLLPESLLAIDNHSNFLNACLQLIGALIVMHLGRDFYIQGFKALWHRQPNMSSLIAIGTSAALISSLWQLYLVYTNHYTDQWSYGHYYFESVCVILMFVMVGKRIENVSKDKALDAMQALMKNAPKTALKMQNNQQIEVLVDSIVVGDILKVLPGSAIAVDGEIIEGEGELDESMLSGEALPVYKKVGDKVFSGTFNSHTSFLMKATQNNKNSTLSQIIEMIYNAQSSKAEISRLADKVSSVFVPSVIAISILAFVVWLIIAPKPDFWWNFGIALEVFVSVLVISCPCALGLATPMSILVANQKASSLGLFFKDAKSLEKARLVNTIVFDKTGTLTNGKPVVKSVHSKIELLELLSLALSIEKSSEHVIAKGIVEYAKEHNAPLKEMSGVKVKTGFGISAKTDYQGTKEIIKVGNSEFFNPINTLEIKENGILVFVGRAISEKEDELLGAFVLEDLPKKGVKEHIAQIKNLGINTFLLSGDNRENVQKCAFELGIDGYISNAKPQDKLNKIKELKEKGQIVMMVGDGLNDAPSLAMSDVAVVMAKGSDVSVQAADIVSFNNDIKSVYSAIKLSQATIKNIKENLFWAFCYNSVFIPLACGVLYKANLMLSPAIAGLAMSLSSVSVVLNSQRLRNFKIKDH |
Keywords
- PTM
Proteomic databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-67 | HMA | ||||
Sequence: MKESFYIEGMTCTACSSGIERSLGRKSFVKKIEVSLLNKSANIEFDENQTNLDEIFKLIEKLGYSPK |
Sequence similarities
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length745
- Mass (Da)81,853
- Last updated1997-11-01 v1
- Checksum855C10A737C072C9
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE000511 EMBL· GenBank· DDBJ | AAD08117.1 EMBL· GenBank· DDBJ | Genomic DNA |