A bow-tie genetic architecture for morphogenesis suggested by a genome- wide RNAi screen in Caenorhabditis elegans.Nelson M.D., Zhou E., Kiontke K., Fradin H., Maldonado G., Martin D., Shah K., Fitch D.H.View abstractCited forFUNCTION, DISRUPTION PHENOTYPECategoriesFunction, Phenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCPLoS Genet. 7:E1002010-E1002010 (2011)Cited in18Mapped to17
Maintenance of muscle myosin levels in adult C. elegans requires both the double bromodomain protein BET-1 and sumoylation.Fisher K., Gee F., Wang S., Xue F., Knapp S., Philpott M., Wells C., Rodriguez M., Snoek L.B.[...], Poulin G.B.View abstractCited forFUNCTION, INTERACTION WITH BET-1, DISRUPTION PHENOTYPECategoriesFunction, Interaction, Phenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCBiol. Open 2:1354-1363 (2013)Cited in2Mapped to18
An RNAi-based dimorphic genetic screen identified the double bromodomain protein BET-1 as a sumo-dependent attenuator of RAS-mediated signalling.Gee F., Fisher K., Klemstein U., Poulin G.B.View abstractCited forFUNCTION, INTERACTION WITH BET-1, DISRUPTION PHENOTYPECategoriesFunction, Interaction, Phenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCPLoS ONE 8:E83659-E83659 (2013)Cited in3Mapped to7
Dynamic SUMO modification regulates mitotic chromosome assembly and cell cycle progression in Caenorhabditis elegans.Pelisch F., Sonneville R., Pourkarimi E., Agostinho A., Blow J.J., Gartner A., Hay R.T.View abstractCited forSUBCELLULAR LOCATION, DISRUPTION PHENOTYPECategoriesPhenotypes & Variants, Subcellular LocationSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNat. Commun. 5:5485-5485 (2014)Cited in6Mapped to3
Caenorhabditis elegans TBX-2 Directly Regulates Its Own Expression in a Negative Autoregulatory Loop.Milton A.C., Okkema P.G.View abstractCited forDISRUPTION PHENOTYPECategoriesPhenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCG3 (Bethesda) 5:1177-1186 (2015)Cited in7
SUMO peptidase ULP-4 regulates mitochondrial UPR-mediated innate immunity and lifespan extension.Gao K., Li Y., Hu S., Liu Y.View abstractCited forFUNCTION, DISRUPTION PHENOTYPECategoriesFunction, Phenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCElife 8:0-0 (2019)Cited in4Mapped to62
Systems-level quantification of division timing reveals a common genetic architecture controlling asynchrony and fate asymmetry.Ho V.W., Wong M.K., An X., Guan D., Shao J., Ng H.C., Ren X., He K., Liao J.[...], Zhao Z.View abstractCategoriesPhenotypes & VariantsSourceWormBase: WBGene00004888PubMedEurope PMCMol Syst Biol 11:814-814 (2015)Mapped to99+
Controlled sumoylation of the mevalonate pathway enzyme HMGS-1 regulates metabolism during aging.Sapir A., Tsur A., Koorman T., Ching K., Mishra P., Bardenheier A., Podolsky L., Bening-Abu-Shach U., Boxem M.[...], Sternberg P.W.View abstractCategoriesPhenotypes & VariantsSourceWormBase: WBGene00004888PubMedEurope PMCProc. Natl. Acad. Sci. U.S.A. 111:E3880-E3889 (2014)Cited in2Mapped to4
Sumoylation regulates ER stress response by modulating calreticulin gene expression in XBP-1-dependent mode in Caenorhabditis elegans.Lim Y., Lee D., Kalichamy K., Hong S.E., Michalak M., Ahnn J., Kim D.H., Lee S.K.View abstractCategoriesPhenotypes & VariantsSourceWormBase: WBGene00004888PubMedEurope PMCInt. J. Biochem. Cell Biol. 53:399-408 (2014)Cited in3Mapped to1
The million mutation project: a new approach to genetics in Caenorhabditis elegans.Thompson O., Edgley M., Strasbourger P., Flibotte S., Ewing B., Adair R., Au V., Chaudhry I., Fernando L.[...], Waterston R.H.View abstractCategoriesPhenotypes & VariantsSourceWormBase: WBGene00004888PubMedEurope PMCGenome Res 23:1749-1762 (2013)Mapped to99+
Caenorhabditis elegans fidgetin homolog FIGL-1, a nuclear-localized AAA ATPase, binds to SUMO.Onitake A., Yamanaka K., Esaki M., Ogura T.View abstractCategoriesInteraction, Phenotypes & VariantsSourceWormBase: WBGene00004888, WormBase: WBGene00004888PubMedEurope PMCJ Struct Biol 179:143-151 (2012)Mapped to4
A genome-wide RNAi screen identifies genes regulating the formation of P bodies in C. elegans and their functions in NMD and RNAi.Sun Y., Yang P., Zhang Y., Bao X., Li J., Hou W., Yao X., Han J., Zhang H.View abstractCategoriesPhenotypes & VariantsSourceWormBase: WBGene00004888PubMedEurope PMCProtein Cell 2:918-939 (2011)Mapped to99+
A fitness assay for comparing RNAi effects across multiple C. elegans genotypes.Elvin M., Snoek L.B., Frejno M., Klemstein U., Kammenga J.E., Poulin G.B.View abstractCategoriesPhenotypes & VariantsSourceWormBase: WBGene00004888PubMedEurope PMCBMC Genomics 12:510-510 (2011)Mapped to62
Functional genomic identification of genes required for male gonadal differentiation in Caenorhabditis elegans.Kalis A.K., Kroetz M.B., Larson K.M., Zarkower D.View abstractCategoriesPhenotypes & VariantsSourceWormBase: WBGene00004888PubMedEurope PMCGenetics 185:523-535 (2010)Mapped to99+
SUMO regulates the assembly and function of a cytoplasmic intermediate filament protein in C. elegans.Kaminsky R., Denison C., Bening-Abu-Shach U., Chisholm A.D., Gygi S.P., Broday L.View abstractCategoriesInteraction, Phenotypes & VariantsSourceWormBase: WBGene00004888, WormBase: WBGene00004888PubMedEurope PMCDev Cell 17:724-735 (2009)Mapped to99+
Protein kinase VRK-1 regulates cell invasion and EGL-17/FGF signaling in Caenorhabditis elegans.Klerkx E.P., Alarcon P., Waters K., Reinke V., Sternberg P.W., Askjaer P.View abstractCategoriesPhenotypes & VariantsSourceWormBase: WBGene00004888PubMedEurope PMCDev. Biol. 335:12-21 (2009)Cited in1Mapped to3
Proteasomal regulation of the hypoxic response modulates aging in C. elegans.Mehta R., Steinkraus K.A., Sutphin G.L., Ramos F.J., Shamieh L.S., Huh A., Davis C., Chandler-Brown D., Kaeberlein M.View abstractCategoriesPhenotypes & VariantsSourceWormBase: WBGene00004888PubMedEurope PMCScience 324:1196-1198 (2009)Cited in2Mapped to53
ZHP-3 acts at crossovers to couple meiotic recombination with synaptonemal complex disassembly and bivalent formation in C. elegans.Bhalla N., Wynne D.J., Jantsch V., Dernburg A.F.View abstractCategoriesPhenotypes & VariantsSourceWormBase: WBGene00004888, WormBase: WBGene00004888PubMedEurope PMCPLoS Genet. 4:e1000235-e1000235 (2008)Cited in1Mapped to16
Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model.Hamamichi S., Rivas R.N., Knight A.L., Cao S., Caldwell K.A., Caldwell G.A.View abstractCategoriesPhenotypes & VariantsSourceWormBase: WBGene00004888PubMedEurope PMCProc. Natl. Acad. Sci. U.S.A. 105:728-733 (2008)Cited in1Mapped to99+
A global analysis of genetic interactions in Caenorhabditis elegans.Byrne A.B., Weirauch M.T., Wong V., Koeva M., Dixon S.J., Stuart J.M., Roy P.J.View abstractCategoriesPhenotypes & VariantsSourceWormBase: WBGene00004888PubMedEurope PMCJ Biol 6:8-8 (2007)Mapped to99+
Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans.Sonnichsen B., Koski L.B., Walsh A., Marschall P., Neumann B., Brehm M., Alleaume A.M., Artelt J., Bettencourt P.[...], Echeverri C.J.View abstractCategoriesPhenotypes & VariantsSourceWormBase: WBGene00004888PubMedEurope PMCNature 434:462-469 (2005)Cited in3Mapped to99+
Toward improving Caenorhabditis elegans phenome mapping with an ORFeome- based RNAi library.Rual J.F., Ceron J., Koreth J., Hao T., Nicot A.S., Hirozane-Kishikawa T., Vandenhaute J., Orkin S.H., Hill D.E.[...], Vidal M.View abstractCategoriesPhenotypes & VariantsSourceWormBase: WBGene00004888PubMedEurope PMCGenome Res 14:2162-2168 (2004)Mapped to99+
BRCA1/BARD1 orthologs required for DNA repair in Caenorhabditis elegans.Boulton S.J., Martin J.S., Polanowska J., Hill D.E., Gartner A., Vidal M.View abstractCategoriesInteraction, Phenotypes & VariantsSourceIntAct: P55853, WormBase: WBGene00004888, WormBase: WBGene00004888PubMedEurope PMCCurr. Biol. 14:33-39 (2004)Cited in3Mapped to9
Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions.Simmer F., Moorman C., van der Linden A.M., Kuijk E., van den Berghe P.V.E., Kamath R.S., Fraser A.G., Ahringer J., Plasterk R.H.A.View abstractCategoriesPhenotypes & VariantsSourceWormBase: WBGene00004888PubMedEurope PMCPLoS Biol. 1:E12-E12 (2003)Cited in24Mapped to99+
Roles for 147 embryonic lethal genes on C.elegans chromosome I identified by RNA interference and video microscopy.Zipperlen P., Fraser A.G., Kamath R.S., Martinez-Campos M., Ahringer J.View abstractCategoriesPhenotypes & VariantsSourceWormBase: WBGene00004888PubMedEurope PMCEMBO J 20:3984-3992 (2001)Mapped to99+