P55826 · PPOC_ARATH
- ProteinProtoporphyrinogen oxidase 1, chloroplastic
- GenePPOX1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids537 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
Catalytic activity
- 3 O2 + protoporphyrinogen IX = 3 H2O2 + protoporphyrin IX
Cofactor
Note: Binds 1 FAD per subunit.
Activity regulation
Inhibited by acifluorfen.
Pathway
Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.
Porphyrin-containing compound metabolism; chlorophyll biosynthesis.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | chloroplast | |
Cellular Component | chloroplast envelope | |
Cellular Component | chloroplast thylakoid | |
Cellular Component | cytosol | |
Molecular Function | oxygen-dependent protoporphyrinogen oxidase activity | |
Biological Process | chlorophyll biosynthetic process | |
Biological Process | porphyrin-containing compound biosynthetic process | |
Biological Process | protoporphyrinogen IX biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtoporphyrinogen oxidase 1, chloroplastic
- EC number
- Short namesPPO1
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionP55826
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
Phenotypes & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 48 variants from UniProt as well as other sources including ClinVar and dbSNP.
Chemistry
PTM/Processing
Features
Showing features for transit peptide, modified residue, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transit peptide | 1-34 | Chloroplast | ||||
Sequence: MELSLLRPTTQSLLPSFSKPNLRLNVYKPLRLRC | ||||||
Modified residue | 35 | N-acetylserine | ||||
Sequence: S | ||||||
Chain | PRO_0000013325 | 35-537 | Protoporphyrinogen oxidase 1, chloroplastic | |||
Sequence: SVAGGPTVGSSKIEGGGGTTITTDCVIVGGGISGLCIAQALATKHPDAAPNLIVTEAKDRVGGNIITREENGFLWEEGPNSFQPSDPMLTMVVDSGLKDDLVLGDPTAPRFVLWNGKLRPVPSKLTDLPFFDLMSIGGKIRAGFGALGIRPSPPGREESVEEFVRRNLGDEVFERLIEPFCSGVYAGDPSKLSMKAAFGKVWKLEQNGGSIIGGTFKAIQERKNAPKAERDPRLPKPQGQTVGSFRKGLRMLPEAISARLGSKVKLSWKLSGITKLESGGYNLTYETPDGLVSVQSKSVVMTVPSHVASGLLRPLSESAANALSKLYYPPVAAVSISYPKEAIRTECLIDGELKGFGQLHPRTQGVETLGTIYSSSLFPNRAPPGRILLLNYIGGSTNTGILSKSEGELVEAVDRDLRKMLIKPNSTDPLKLGVRVWPQAIPQFLVGHFDILDTAKSSLTSSGYEGLFLGGNYVAGVALGRCVEGAYETAIEVNNFMSRYAYK |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed at high levels in the leaves and at low levels in the roots and floral buds.
Gene expression databases
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 256-275 | Disordered | ||||
Sequence: RKNAPKAERDPRLPKPQGQT |
Sequence similarities
Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
This entry describes 2 isoforms produced by Alternative splicing.
P55826-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length537
- Mass (Da)57,695
- Last updated1997-11-01 v1
- ChecksumC125B0EE1D3187D5
P55826-2
- Name2
- Differences from canonical
- 447-477: Missing
Sequence caution
Features
Showing features for sequence conflict, alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 302 | in Ref. 4; AAK62389 | ||||
Sequence: W → C | ||||||
Alternative sequence | VSP_046547 | 447-477 | in isoform 2 | |||
Sequence: Missing |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
D83139 EMBL· GenBank· DDBJ | BAA11820.1 EMBL· GenBank· DDBJ | mRNA | ||
AF104919 EMBL· GenBank· DDBJ | AAC72870.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
AL161492 EMBL· GenBank· DDBJ | CAB77739.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002687 EMBL· GenBank· DDBJ | AEE82064.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002687 EMBL· GenBank· DDBJ | AEE82065.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF386944 EMBL· GenBank· DDBJ | AAK62389.1 EMBL· GenBank· DDBJ | mRNA | ||
BT020418 EMBL· GenBank· DDBJ | AAV97809.1 EMBL· GenBank· DDBJ | mRNA | ||
BT020535 EMBL· GenBank· DDBJ | AAW70381.1 EMBL· GenBank· DDBJ | mRNA |