P55353 · FCL_SINFN

Function

function

Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

Catalytic activity

Pathway

Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.

Features

Showing features for binding site, site, active site.

131420406080100120140160180200220240260280300
TypeIDPosition(s)Description
Binding site15-21NADP+ (UniProtKB | ChEBI)
Binding site109-112NADP+ (UniProtKB | ChEBI)
Site111Important for catalytic activity
Site113Important for catalytic activity
Active site140Proton donor/acceptor
Binding site144NADP+ (UniProtKB | ChEBI)
Binding site167-170NADP+ (UniProtKB | ChEBI)
Binding site183NADP+ (UniProtKB | ChEBI)
Binding site191substrate
Binding site206substrate
Binding site213substrate
Binding site273substrate

GO annotations

AspectTerm
Molecular FunctionGDP-L-fucose synthase activity
Molecular Functionisomerase activity
Molecular FunctionNADP+ binding
Biological Process'de novo' GDP-L-fucose biosynthetic process
Biological Processnodulation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    GDP-L-fucose synthase
  • EC number
  • Alternative names
    • GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase

Gene names

    • Name
      fcl
    • ORF names
      y4aF
    • Ordered locus names
      NGR_a00420

Encoded on

  • Plasmid sym pNGR234a

Organism names

Accessions

  • Primary accession
    P55353

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001743601-314GDP-L-fucose synthase

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    314
  • Mass (Da)
    34,674
  • Last updated
    1997-11-01 v1
  • Checksum
    2E571D298AA98110
MPMYLLDGKRIWVAGHKGMVGSAIIRSLASEDCEVIVADRQKLDLTRQEEVEKFLLKEKPHAVIMAAAKVGGILANDTMPADFIYQNLIMEANVIEGSFRSGVEKLLFLGSSCIYPKYAAQPIREEALLTGPLEPTNEWYAIAKIAGIKLCQAYRKQYGANFISAMPTNLYGPRDKFDLNSSHVVPALIRKAHEAKIKDLGCLSIWGSGTPTRDFLYSEDCSDALVFLLKHYSETEHINIGSGGEISIIELAHIVCRVVGFKGDIVFDTSKPDGTPRKLLSSERLVSMGWRPKTSLELGLAKSYESFVSNVADN

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U00090
EMBL· GenBank· DDBJ
AAB91603.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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