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P55314 · CO8B_RAT

  • Protein
    Complement component C8 beta chain
  • Gene
    C8b
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

function

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Cellular Componentextracellular space
Cellular Componentmembrane attack complex
Molecular Functionprotein-containing complex binding
Biological Processcomplement activation
Biological Processcomplement activation, alternative pathway
Biological Processcomplement activation, classical pathway
Biological Processkilling of cells of another organism

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Complement component C8 beta chain
  • Alternative names
    • Complement component 8 subunit beta

Gene names

    • Name
      C8b

Organism names

  • Taxonomic identifier
  • Strains
    • Brown Norway
    • Brown Norway/Crl
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    P55314
  • Secondary accessions
    • Q5EB58

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for signal, propeptide, glycosylation, chain, disulfide bond, modified residue.

Type
IDPosition(s)Description
Signal1-31
PropeptidePRO_000029130532-53
Glycosylation43N-linked (GlcNAc...) asparagine
ChainPRO_000016250954-589Complement component C8 beta chain
Disulfide bond64↔99
Glycosylation69C-linked (Man) tryptophan
Glycosylation72C-linked (Man) tryptophan
Disulfide bond75↔78
Disulfide bond109↔115
Disulfide bond121↔132
Disulfide bond126↔145
Disulfide bond139↔154
Glycosylation242N-linked (GlcNAc...) asparagine
Modified residue417Phosphothreonine
Disulfide bond502↔549
Disulfide bond504↔520
Disulfide bond507↔522
Disulfide bond524↔533
Glycosylation550C-linked (Man) tryptophan
Glycosylation553C-linked (Man) tryptophan
Disulfide bond556↔589

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Heterotrimer of 3 chains: alpha, beta and gamma. The alpha and gamma chains are disulfide bonded. Component of the membrane attack complex (MAC). MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b sequentially binds C6, C7, C8 and multiple copies of the pore-forming subunit C9 (By similarity).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, compositional bias, region.

Type
IDPosition(s)Description
Domain63-116TSP type-1 1
Domain120-155LDL-receptor class A
Domain157-503MACPF
Domain504-534EGF-like
Domain544-587TSP type-1 2
Compositional bias556-575Polar residues
Region556-589Disordered

Sequence similarities

Belongs to the complement C6/C7/C8/C9 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    589
  • Mass (Da)
    66,667
  • Last updated
    2007-06-12 v2
  • MD5 Checksum
    ACA86181DD3F08CD458F0753DFC172E3
MKTGAQVWRALAKSCLLCAALGCLHLPGARGEKPDFFETNAVNGSLVRSRPVRSVDVTPAPTDCQLSTWSSWTACDPCQKKRYRHTYLLRPSQFYGELCDFSDKEVEDCVTNRACRSQVRCEGFVCAQTGRCVNRRLLCNGDNDCGDQSDEANCRRIYKKCSQDMEQYWAIGNLASGINLFTNTFEGPVLDHRYYAGACSPHYILNTNFRKPYNVESYTPQTQGKYEFALTEYESYFDFEHNVTEKATSKSSFKFGFKLDGLVEFGVRKESNEGRHYISRTKRFSHTKSKFLHARSVLEVAHYKLKSRQLMLHYEFLQRVKSLPLEYSYGEYRDLLRDFGTHFITEAVLGGIYEYTLIMNKDAMERGDYTLDHVSACAGGGFQIGGNVYKVYLKLGVSEKKCSDILNEIKDRNKRRTMVEDLVVLVRGGTSEYITSLAYKDLPTAELMKEWGDAVQYNPAIIKLKAEPLYELVTATDFAYSSTVKQNMKKALEEFQMEVSSCRCAPCRNNGVPILKESRCECICPAGFQGVACEVTNRKDIPIDGKWSCWSDWSPCSGGRKTRQRQCNNPAPQRGGSPCSGPASETLDC

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8I6GLE3A0A8I6GLE3_RATC8b523
A0A8I5ZWX9A0A8I5ZWX9_RATC8b556

Sequence caution

The sequence CO561829 differs from that shown. Reason: Frameshift

Features

Showing features for sequence conflict, compositional bias.

Type
IDPosition(s)Description
Sequence conflict451in Ref. 3; AAA82890
Sequence conflict458in Ref. 3; AAA82890
Sequence conflict464in Ref. 3; AAA82890
Sequence conflict497in Ref. 3; AAA82890
Sequence conflict526-528in Ref. 3; AAA82890
Compositional bias556-575Polar residues
Sequence conflict588in Ref. 3; AAA82890

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AABR03041555
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AABR03042213
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CO561829
EMBL· GenBank· DDBJ
-mRNA No translation available.
BC090023
EMBL· GenBank· DDBJ
AAH90023.1
EMBL· GenBank· DDBJ
mRNA
U20194
EMBL· GenBank· DDBJ
AAA82890.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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