P55314 · CO8B_RAT
- ProteinComplement component C8 beta chain
- GeneC8b
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids589 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Cellular Component | extracellular space | |
Cellular Component | membrane attack complex | |
Molecular Function | protein-containing complex binding | |
Biological Process | complement activation | |
Biological Process | complement activation, alternative pathway | |
Biological Process | complement activation, classical pathway | |
Biological Process | killing of cells of another organism |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameComplement component C8 beta chain
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionP55314
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for signal, propeptide, glycosylation, chain, disulfide bond, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-31 | ||||
Propeptide | PRO_0000291305 | 32-53 | |||
Glycosylation | 43 | N-linked (GlcNAc...) asparagine | |||
Chain | PRO_0000162509 | 54-589 | Complement component C8 beta chain | ||
Disulfide bond | 64↔99 | ||||
Glycosylation | 69 | C-linked (Man) tryptophan | |||
Glycosylation | 72 | C-linked (Man) tryptophan | |||
Disulfide bond | 75↔78 | ||||
Disulfide bond | 109↔115 | ||||
Disulfide bond | 121↔132 | ||||
Disulfide bond | 126↔145 | ||||
Disulfide bond | 139↔154 | ||||
Glycosylation | 242 | N-linked (GlcNAc...) asparagine | |||
Modified residue | 417 | Phosphothreonine | |||
Disulfide bond | 502↔549 | ||||
Disulfide bond | 504↔520 | ||||
Disulfide bond | 507↔522 | ||||
Disulfide bond | 524↔533 | ||||
Glycosylation | 550 | C-linked (Man) tryptophan | |||
Glycosylation | 553 | C-linked (Man) tryptophan | |||
Disulfide bond | 556↔589 | ||||
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Subunit
Heterotrimer of 3 chains: alpha, beta and gamma. The alpha and gamma chains are disulfide bonded. Component of the membrane attack complex (MAC). MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b sequentially binds C6, C7, C8 and multiple copies of the pore-forming subunit C9 (By similarity).
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 63-116 | TSP type-1 1 | |||
Domain | 120-155 | LDL-receptor class A | |||
Domain | 157-503 | MACPF | |||
Domain | 504-534 | EGF-like | |||
Domain | 544-587 | TSP type-1 2 | |||
Compositional bias | 556-575 | Polar residues | |||
Region | 556-589 | Disordered | |||
Sequence similarities
Belongs to the complement C6/C7/C8/C9 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length589
- Mass (Da)66,667
- Last updated2007-06-12 v2
- MD5 ChecksumACA86181DD3F08CD458F0753DFC172E3
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8I6GLE3 | A0A8I6GLE3_RAT | C8b | 523 | ||
A0A8I5ZWX9 | A0A8I5ZWX9_RAT | C8b | 556 |
Sequence caution
Features
Showing features for sequence conflict, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Sequence conflict | 451 | in Ref. 3; AAA82890 | |||
Sequence conflict | 458 | in Ref. 3; AAA82890 | |||
Sequence conflict | 464 | in Ref. 3; AAA82890 | |||
Sequence conflict | 497 | in Ref. 3; AAA82890 | |||
Sequence conflict | 526-528 | in Ref. 3; AAA82890 | |||
Compositional bias | 556-575 | Polar residues | |||
Sequence conflict | 588 | in Ref. 3; AAA82890 | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AABR03041555 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AABR03042213 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CO561829 EMBL· GenBank· DDBJ | - | mRNA | No translation available. | |
BC090023 EMBL· GenBank· DDBJ | AAH90023.1 EMBL· GenBank· DDBJ | mRNA | ||
U20194 EMBL· GenBank· DDBJ | AAA82890.1 EMBL· GenBank· DDBJ | mRNA |