P55289 · CAD12_HUMAN

  • Protein
    Cadherin-12
  • Gene
    CDH12
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentadherens junction
Cellular Componentcatenin complex
Cellular Componentplasma membrane
Molecular Functionbeta-catenin binding
Molecular Functioncadherin binding
Molecular Functioncalcium ion binding
Biological Processadherens junction organization
Biological Processcalcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
Biological Processcell migration
Biological Processcell morphogenesis
Biological Processcell-cell adhesion mediated by cadherin
Biological Processcell-cell junction assembly
Biological Processhomophilic cell adhesion via plasma membrane adhesion molecules

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cadherin-12
  • Alternative names
    • Brain cadherin (BR-cadherin)
    • Neural type cadherin 2 (N-cadherin 2)

Gene names

    • Name
      CDH12

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    P55289
  • Secondary accessions
    • B2RBT1
    • B7Z2U6
    • Q86UD2

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain55-609Extracellular
Transmembrane610-637Helical
Topological domain638-794Cytoplasmic

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_04850568in dbSNP:rs4371716
Natural variantVAR_048506284in dbSNP:rs17328673
Natural variantVAR_048507475in dbSNP:rs12108814

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 1,381 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for signal, propeptide, chain, glycosylation, modified residue.

TypeIDPosition(s)Description
Signal1-23
PropeptidePRO_000000379124-54
ChainPRO_000000379255-794Cadherin-12
Glycosylation256N-linked (GlcNAc...) asparagine
Glycosylation456N-linked (GlcNAc...) asparagine
Glycosylation537N-linked (GlcNAc...) asparagine
Glycosylation545N-linked (GlcNAc...) asparagine
Modified residue787Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Brain.

Gene expression databases

    • ENSG00000154162Expressed in male germ line stem cell (sensu Vertebrata) in testis and 93 other cell types or tissues

Organism-specific databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain55-160Cadherin 1
Domain161-269Cadherin 2
Domain270-384Cadherin 3
Domain385-487Cadherin 4
Domain488-609Cadherin 5

Domain

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 2 isoforms produced by Alternative splicing.

P55289-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    794
  • Mass (Da)
    88,332
  • Last updated
    2007-08-21 v2
  • Checksum
    76DF39AB56E7BC2D
MLTRNCLSLLLWVLFDGGLLTPLQPQPQQTLATEPRENVIHLPGQRSHFQRVKRGWVWNQFFVLEEYVGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAGTVFTIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETRKPLEPESEFIIKVQDINDNEPKFLDGPYVATVPEMSPVGAYVLQVKATDADDPTYGNSARVVYSILQGQPYFSIDPKTGVIRTALPNMDREVKEQYQVLIQAKDMGGQLGGLAGTTIVNITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVDPDFGQNAEIEYNIVPGDGGNLFDIVTDEDTQEGVIKLKKPLDFETKKAYTFKVEASNLHLDHRFHSAGPFKDTATVKISVLDVDEPPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDVGSSAVRYFIDWKSDGDSYFTIDGNEGTIATNELLDRESTAQYNFSIIASKVSNPLLTSKVNILINVLDVNEFPPEISVPYETAVCENAKPGQIIQIVSAADRDLSPAGQQFSFRLSPEAAIKPNFTVRDFRNNTAGIETRRNGYSRRQQELYFLPVVIEDSSYPVQSSTNTMTIRVCRCDSDGTILSCNVEAIFLPVGLSTGALIAILLCIVILLAIVVLYVALRRQKKKDTLMTSKEDIRDNVIHYDDEGGGEEDTQAFDIGALRNPKVIEENKIRRDIKPDSLCLPRQRPPMEDNTDIRDFIHQRLQENDVDPTAPPYDSLATYAYEGSGSVAESLSSIDSLTTEADQDYDYLTDWGPRFKVLADMFGEEESYNPDKVT

P55289-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Features

Showing features for alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_056449176-215in isoform 2
Sequence conflict349in Ref. 2; AAB48539
Sequence conflict416in Ref. 1; AAA35623
Sequence conflict644in Ref. 1; AAA35623
Sequence conflict733in Ref. 1; AAA35623
Sequence conflict761in Ref. 2; AAB48539

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
L34057
EMBL· GenBank· DDBJ
AAA35623.1
EMBL· GenBank· DDBJ
mRNA
L33477
EMBL· GenBank· DDBJ
AAB48539.1
EMBL· GenBank· DDBJ
mRNA
AK295123
EMBL· GenBank· DDBJ
BAH11982.1
EMBL· GenBank· DDBJ
mRNA
AK314800
EMBL· GenBank· DDBJ
BAG37328.1
EMBL· GenBank· DDBJ
mRNA
AC022139
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC026716
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC034239
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC091938
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC093263
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC108089
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC109455
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC138854
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC138940
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC139497
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC140132
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC140171
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471118
EMBL· GenBank· DDBJ
EAX10736.1
EMBL· GenBank· DDBJ
Genomic DNA
BC047608
EMBL· GenBank· DDBJ
AAH47608.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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