P55156 · MTP_BOVIN
- ProteinMicrosomal triglyceride transfer protein large subunit
- GeneMTTP
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids887 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces (PubMed:15897609, PubMed:8876250).
Required for the assembly and secretion of plasma lipoproteins that contain apolipoprotein B (By similarity).
May be involved in regulating cholesteryl ester biosynthesis in cells that produce lipoproteins (By similarity).
Required for the assembly and secretion of plasma lipoproteins that contain apolipoprotein B (By similarity).
May be involved in regulating cholesteryl ester biosynthesis in cells that produce lipoproteins (By similarity).
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)This reaction proceeds in the forward direction.
- a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)This reaction proceeds in the forward direction.
- a cholesterol ester(in) = a cholesterol ester(out)This reaction proceeds in the forward direction.
- a triacyl-sn-glycerol(in) = a triacyl-sn-glycerol(out)This reaction proceeds in the forward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | basolateral plasma membrane | |
Cellular Component | endoplasmic reticulum | |
Cellular Component | Golgi apparatus | |
Molecular Function | ceramide 1-phosphate transfer activity | |
Molecular Function | cholesterol transfer activity | |
Molecular Function | lipid binding | |
Molecular Function | phosphatidylethanolamine transfer activity | |
Molecular Function | phospholipid transporter activity | |
Molecular Function | protein heterodimerization activity | |
Molecular Function | triglyceride transfer activity | |
Biological Process | cholesterol homeostasis | |
Biological Process | lipoprotein metabolic process | |
Biological Process | phospholipid transport | |
Biological Process | plasma lipoprotein particle assembly | |
Biological Process | protein secretion | |
Biological Process | triglyceride transport |
Keywords
- Biological process
- Ligand
Chemistry
Names & Taxonomy
Protein names
- Recommended nameMicrosomal triglyceride transfer protein large subunit
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos
Accessions
- Primary accessionP55156
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Note: Colocalizes with P4HB/PDI in the endoplasmic reticulum.
Keywords
- Cellular component
Phenotypes & Variants
Chemistry
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-11 | |||||
Sequence: FLCFISSYSAS | ||||||
Chain | PRO_0000041592 | 12-887 | Microsomal triglyceride transfer protein large subunit | |||
Sequence: VKGHTTGLSLNNDRLYKLTYSTEVFLDRGKGNLQDSVGYRISSNVDVALLWRSPDGDDNQLIQITMKDVNLENVNQQRGEKSIFKGKKSSQIIRKENLEAMQRPVLLHLIHGKIKEFYSYQNEPAAIENLKRGLASLFQMQLSSGTTNEVDISGDCKVTYQAHQDKVTKIKALDSCKIERAGFTTPHQVLGVTSKATSVTTYKIEDSFVVAVLSEEIRALRLNFLQSIAGKIVSRQKLELKTTEASVRLKPGKQVAAIIKAVDSKYTAIPIVGQVFQSKCKGCPSLSEHWQSIRKHLQPDNLSKAEAVRSFLAFIKHLRTAKKEEILQILKAENKEVLPQLVDAVTSAQTPDSLDAILDFLDFKSTESVILQERFLYACAFASHPDEELLRALISKFKGSFGSNDIRESVMIIIGALVRKLCQNQGCKLKGVIEAKKLILGGLEKAEKKEDIVMYLLALKNARLPEGIPLLLKYTETGEGPISHLAATTLQRYDVPFITDEVKKTMNRIYHQNRKIHEKTVRTTAAAIILKNNPSYMEVKNILLSIGELPKEMNKYMLSIVQDILRFETPASKMVRQVLKEMVAHNYDRFSKSGSSSAYTGYVERTSHSASTYSLDILYSGSGILRRSNLNIFQYIEKTPLHGIQVVIEAQGLEALIAATPDEGEENLDSYAGLSALLFDVQLRPVTFFNGYSDLMSKMLSASSDPMSVVKGLLLLIDHSQELQLQSGLKANMDVQGGLAIDITGAMEFSLWYRESKTRVKNRVSVLITGGITVDSSFVKAGLEIGAETEAGLEFISTVQFSQYPFLVCLQMDKEDVPYRQFETKYERLSTGRGYISRKRKESLIGGCEFPLHQENSDMCKVVFAPQPESSSSGWF | ||||||
Disulfide bond | 167↔187 | |||||
Sequence: CKVTYQAHQDKVTKIKALDSC |
Keywords
- PTM
Proteomic databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 21-655 | Vitellogenin | ||||
Sequence: LNNDRLYKLTYSTEVFLDRGKGNLQDSVGYRISSNVDVALLWRSPDGDDNQLIQITMKDVNLENVNQQRGEKSIFKGKKSSQIIRKENLEAMQRPVLLHLIHGKIKEFYSYQNEPAAIENLKRGLASLFQMQLSSGTTNEVDISGDCKVTYQAHQDKVTKIKALDSCKIERAGFTTPHQVLGVTSKATSVTTYKIEDSFVVAVLSEEIRALRLNFLQSIAGKIVSRQKLELKTTEASVRLKPGKQVAAIIKAVDSKYTAIPIVGQVFQSKCKGCPSLSEHWQSIRKHLQPDNLSKAEAVRSFLAFIKHLRTAKKEEILQILKAENKEVLPQLVDAVTSAQTPDSLDAILDFLDFKSTESVILQERFLYACAFASHPDEELLRALISKFKGSFGSNDIRESVMIIIGALVRKLCQNQGCKLKGVIEAKKLILGGLEKAEKKEDIVMYLLALKNARLPEGIPLLLKYTETGEGPISHLAATTLQRYDVPFITDEVKKTMNRIYHQNRKIHEKTVRTTAAAIILKNNPSYMEVKNILLSIGELPKEMNKYMLSIVQDILRFETPASKMVRQVLKEMVAHNYDRFSKSGSSSAYTGYVERTSHSASTYSLDILYSGSGILRRSNLNIFQYIEKTPLHGI |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusFragment
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length887
- Mass (Da)99,032
- Last updated1996-10-01 v1
- Checksum45CD454541054BBF
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: F |
Keywords
- Technical term