P55156 · MTP_BOVIN

  • Protein
    Microsomal triglyceride transfer protein large subunit
  • Gene
    MTTP
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces (PubMed:15897609, PubMed:8876250).
Required for the assembly and secretion of plasma lipoproteins that contain apolipoprotein B (By similarity).
May be involved in regulating cholesteryl ester biosynthesis in cells that produce lipoproteins (By similarity).

Catalytic activity

  • a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)
    This reaction proceeds in the forward direction.
  • a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)
    This reaction proceeds in the forward direction.
  • a cholesterol ester(in) = a cholesterol ester(out)
    This reaction proceeds in the forward direction.
  • a triacyl-sn-glycerol(in) = a triacyl-sn-glycerol(out)
    This reaction proceeds in the forward direction.

GO annotations

AspectTerm
Cellular Componentbasolateral plasma membrane
Cellular Componentendoplasmic reticulum
Cellular ComponentGolgi apparatus
Molecular Functionceramide 1-phosphate transfer activity
Molecular Functioncholesterol transfer activity
Molecular Functionlipid binding
Molecular Functionphosphatidylethanolamine transfer activity
Molecular Functionphospholipid transporter activity
Molecular Functionprotein heterodimerization activity
Molecular Functiontriglyceride transfer activity
Biological Processcholesterol homeostasis
Biological Processlipoprotein metabolic process
Biological Processphospholipid transport
Biological Processplasma lipoprotein particle assembly
Biological Processprotein secretion
Biological Processtriglyceride transport

Keywords

Chemistry

Names & Taxonomy

Protein names

  • Recommended name
    Microsomal triglyceride transfer protein large subunit

Gene names

    • Name
      MTTP
    • Synonyms
      MTP

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    P55156

Proteomes

Subcellular Location

Endoplasmic reticulum
Golgi apparatus
Note: Colocalizes with P4HB/PDI in the endoplasmic reticulum.

Keywords

Phenotypes & Variants

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-11
ChainPRO_000004159212-887Microsomal triglyceride transfer protein large subunit
Disulfide bond167↔187

Keywords

Proteomic databases

Interaction

Subunit

Heterodimer; heterodimerizes with the protein disulfide isomerase (P4HB/PDI) (PubMed:2351674).
Interacts with APOB (By similarity).
Interacts with PRAP1 (By similarity).

Protein-protein interaction databases

Chemistry

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain21-655Vitellogenin

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    887
  • Mass (Da)
    99,032
  • Last updated
    1996-10-01 v1
  • Checksum
    45CD454541054BBF
FLCFISSYSASVKGHTTGLSLNNDRLYKLTYSTEVFLDRGKGNLQDSVGYRISSNVDVALLWRSPDGDDNQLIQITMKDVNLENVNQQRGEKSIFKGKKSSQIIRKENLEAMQRPVLLHLIHGKIKEFYSYQNEPAAIENLKRGLASLFQMQLSSGTTNEVDISGDCKVTYQAHQDKVTKIKALDSCKIERAGFTTPHQVLGVTSKATSVTTYKIEDSFVVAVLSEEIRALRLNFLQSIAGKIVSRQKLELKTTEASVRLKPGKQVAAIIKAVDSKYTAIPIVGQVFQSKCKGCPSLSEHWQSIRKHLQPDNLSKAEAVRSFLAFIKHLRTAKKEEILQILKAENKEVLPQLVDAVTSAQTPDSLDAILDFLDFKSTESVILQERFLYACAFASHPDEELLRALISKFKGSFGSNDIRESVMIIIGALVRKLCQNQGCKLKGVIEAKKLILGGLEKAEKKEDIVMYLLALKNARLPEGIPLLLKYTETGEGPISHLAATTLQRYDVPFITDEVKKTMNRIYHQNRKIHEKTVRTTAAAIILKNNPSYMEVKNILLSIGELPKEMNKYMLSIVQDILRFETPASKMVRQVLKEMVAHNYDRFSKSGSSSAYTGYVERTSHSASTYSLDILYSGSGILRRSNLNIFQYIEKTPLHGIQVVIEAQGLEALIAATPDEGEENLDSYAGLSALLFDVQLRPVTFFNGYSDLMSKMLSASSDPMSVVKGLLLLIDHSQELQLQSGLKANMDVQGGLAIDITGAMEFSLWYRESKTRVKNRVSVLITGGITVDSSFVKAGLEIGAETEAGLEFISTVQFSQYPFLVCLQMDKEDVPYRQFETKYERLSTGRGYISRKRKESLIGGCEFPLHQENSDMCKVVFAPQPESSSSGWF

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X78567
EMBL· GenBank· DDBJ
CAA55310.1
EMBL· GenBank· DDBJ
mRNA

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