P55090 · UCN1_RAT

Function

function

Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH) (PubMed:7477349).
Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta (By similarity).
Plays a role in the establishment of normal hearing thresholds (By similarity).
Reduces food intake and regulates ghrelin levels in gastric body and plasma (PubMed:21540451).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentaxon
Cellular Componentaxon terminus
Cellular Componentdendrite
Cellular Componentextracellular region
Cellular Componentneuronal cell body
Cellular Componentperikaryon
Cellular Componentvaricosity
Molecular Functioncorticotropin-releasing hormone receptor 1 binding
Molecular Functioncorticotropin-releasing hormone receptor 2 binding
Molecular FunctionG protein-coupled receptor binding
Molecular Functionhistone deacetylase inhibitor activity
Molecular Functionhormone activity
Biological Processaerobic respiration
Biological Processassociative learning
Biological Processdrinking behavior
Biological Processfeeding behavior
Biological Processfemale pregnancy
Biological Processlearning or memory
Biological Processnegative regulation of apoptotic process
Biological Processnegative regulation of appetite
Biological Processnegative regulation of blood pressure
Biological Processnegative regulation of cell size
Biological Processnegative regulation of feeding behavior
Biological Processnegative regulation of gene expression
Biological Processnegative regulation of hormone secretion
Biological Processnegative regulation of neuron apoptotic process
Biological Processneuron projection development
Biological Processneuropeptide signaling pathway
Biological Processpositive regulation of behavioral fear response
Biological Processpositive regulation of calcium ion import
Biological Processpositive regulation of cAMP-mediated signaling
Biological Processpositive regulation of cardiac muscle contraction
Biological Processpositive regulation of cell growth
Biological Processpositive regulation of collagen biosynthetic process
Biological Processpositive regulation of corticotropin secretion
Biological Processpositive regulation of DNA replication
Biological Processpositive regulation of gene expression
Biological Processpositive regulation of interleukin-6 production
Biological Processpositive regulation of peptidyl-serine phosphorylation
Biological Processpositive regulation of protein phosphorylation
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processpositive regulation of translation
Biological Processpositive regulation of vascular permeability
Biological Processregulation of synaptic transmission, glutamatergic
Biological Processresponse to auditory stimulus
Biological Processresponse to estradiol
Biological Processresponse to glucocorticoid
Biological Processresponse to oxidative stress
Biological Processresponse to pain
Biological Processsensory perception of sound
Biological Processsocial behavior
Biological Processstartle response
Biological Processvasodilation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Urocortin
  • Alternative names
    • Corticotensin

Gene names

    • Name
      Ucn

Organism names

  • Taxonomic identifier
  • Strains
    • Sprague-Dawley
    • Lewis
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    P55090

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for signal, propeptide, peptide, modified residue.

TypeIDPosition(s)Description
Signal1-25
PropeptidePRO_000000623726-80
PeptidePRO_000000623881-120Urocortin
Modified residue120Valine amide

Keywords

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Interacts with CRHR1 and CRHR2 (via their N-terminal extracellular domain).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY P55090Crhr1 P353533EBI-9030248, EBI-9030306

Protein-protein interaction databases

Structure

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    122
  • Mass (Da)
    13,711
  • Last updated
    1996-10-01 v1
  • Checksum
    9F0AF834CBFFCE74
MRQRGRATLLVALLLLVQLRPESSQWSPAAAAANVVQDPNLRWNPGVRNQGGGVRALLLLLAERFPRRAGSEPAGERQRRDDPPLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSVGK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U33935
EMBL· GenBank· DDBJ
AAA87566.1
EMBL· GenBank· DDBJ
mRNA
AF093623
EMBL· GenBank· DDBJ
AAF63153.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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