P54923 · ADPRH_MOUSE

  • Protein
    ADP-ribosylhydrolase ARH1
  • Gene
    Adprh
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Specifically acts as an arginine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to arginine residues on proteins.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 2 magnesium ions per subunit.

Activity regulation

Synergistically stimulated by magnesium and dithiothreitol (DTT) in vitro.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site59Mg2+ 1 (UniProtKB | ChEBI)
Binding site60Mg2+ 1 (UniProtKB | ChEBI)
Binding site61Mg2+ 1 (UniProtKB | ChEBI)
Binding site90substrate
Binding site129substrate
Binding site135substrate
Binding site307Mg2+ 2 (UniProtKB | ChEBI)
Binding site309Mg2+ 1 (UniProtKB | ChEBI)
Binding site309Mg2+ 2 (UniProtKB | ChEBI)
Binding site310Mg2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentextracellular space
Molecular FunctionADP-ribosylarginine hydrolase activity
Molecular Functionmagnesium ion binding
Molecular Functionpotassium ion binding
Biological Processprotein de-ADP-ribosylation
Biological Processprotein modification process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ADP-ribosylhydrolase ARH1
  • EC number
  • Alternative names
    • ADP-ribose-L-arginine cleaving enzyme
    • [Protein ADP-ribosylarginine] hydrolase (ADP-ribosylarginine hydrolase)

Gene names

    • Name
      Adprh
    • Synonyms
      Arh1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P54923

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001572841-362ADP-ribosylhydrolase ARH1

Proteomic databases

2D gel databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region106-108Substrate
Region168-170Substrate
Region268-270Substrate
Region274-275Substrate

Sequence similarities

Belongs to the ADP-ribosylglycohydrolase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    362
  • Mass (Da)
    40,068
  • Last updated
    1996-10-01 v1
  • Checksum
    E06BCAEF69BA7C4E
MGGGLIERYVAAMVLSAAGDTLGYFNGKWEFIRDGETIHQQLAQMGDLEAIDVARWRVSDDTVMHLATAEALMEAGQSPDLPRLYSLLAKHYRDCMGDMDGRAPGGACMQNAMLLQPNRADGYRIPFNSHEGGCGAAMRAMCIGLRFPHPSQLDLLIQVSIESGRMTHHHPTGYLGSLASALFTAYAVNGKSPWQWGKGLMEVLPEAKKYITQSGYFVKENLQHWSYFEKEWEKYLELRGILDGNSAPVFPQPFGVKERDQFYIDVSYSGWGGSSGHDAPMIAYDALLAAGDSWKELAHRAFFHGGDSDSTAAIAGCWWGVMYGFKGVNPANYEKLEYRQRLEEAGRALYSLGSKEDPVLDP

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
L13290
EMBL· GenBank· DDBJ
AAA37259.1
EMBL· GenBank· DDBJ
mRNA
AF244347
EMBL· GenBank· DDBJ
AAF86223.1
EMBL· GenBank· DDBJ
mRNA
BC003437
EMBL· GenBank· DDBJ
AAH03437.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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