P54921 · SNAA_RAT

  • Protein
    Alpha-soluble NSF attachment protein
  • Gene
    Napa
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. Together with GNA12 promotes CDH5 localization to plasma membrane.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentglutamatergic synapse
Cellular Componentneuromuscular junction
Cellular Componentpostsynapse
Cellular Componentpresynapse
Cellular Componentpresynaptic active zone membrane
Cellular Componentsynaptobrevin 2-SNAP-25-syntaxin-1a complex
Cellular Componentterminal bouton
Molecular Functionprotein-containing complex binding
Molecular FunctionSNARE binding
Molecular Functionsoluble NSF attachment protein activity
Molecular Functionsyntaxin binding
Biological Processapical protein localization
Biological Processbrain development
Biological Processintracellular protein transport
Biological Processmembrane fusion
Biological Processneuron differentiation
Biological Processpositive regulation of ATP-dependent activity
Biological Processprotein-containing complex disassembly
Biological Processregulation of synaptic vesicle priming
Biological ProcessSNARE complex disassembly
Biological Processsynaptic transmission, glutamatergic
Biological Processsynaptic vesicle priming

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Alpha-soluble NSF attachment protein
  • Short names
    SNAP-alpha
  • Alternative names
    • N-ethylmaleimide-sensitive factor attachment protein alpha

Gene names

    • Name
      Napa
    • Synonyms
      Snap, Snapa

Organism names

  • Taxonomic identifier
  • Strain
    • Wistar
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    P54921

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for modified residue, chain.

TypeIDPosition(s)Description
Modified residue1N-acetylmethionine
ChainPRO_00002190581-295Alpha-soluble NSF attachment protein
Modified residue26Phosphoserine
Modified residue29Phosphoserine
Modified residue195Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Interacts with PRKCABP, and disrupts the interaction between GRIA2 and PRKCABP, leading to the internalization of GRIA2 (PubMed:11931741).
Found in a complex with VAMP8 (PubMed:9614193).
Component of a SNARE-like complex that contains at least ZW10, USE1L, RINT1, STX18 and NAPA/SNAP-alpha (By similarity).
Interacts with VTI1A (By similarity).
Interacts with STX12 (PubMed:9507000).
Interacts with GNA12 (via N-terminus); the interaction promotes CDH5 localization to plasma membrane (By similarity).

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the SNAP family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    295
  • Mass (Da)
    33,193
  • Last updated
    1999-07-15 v2
  • Checksum
    662356859DF0BA3F
MDTSGKQAEAMALLAEAERKVKNSQSFFSGLFGGSSKIEEACEIYARAANMFKMAKNWSAAGNAFCQAAQLHLQLQSKHDAATCFVDAGNAFKKADPQEAINCLMRAIEIYTDMGRFTIAAKHHISIAEIYETELVDVEKAIAHYEQSADYYKGEESNSSANKCLLKVAGYAAQLEQYQKAIDIYEQVGTSAMDSPLLKYSAKDYFFKAALCHFCIDMLNAKLAVQKYEELFPAFSDSRECKLMKKLLEAHEEQNVDSYTESVKEYDSISRLDQWLTTMLLRIKKTIQGDEEDLR

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8L2PZF0A0A8L2PZF0_RATNapa291
A0A8I5ZJF7A0A8I5ZJF7_RATNapa271
A0A8I5ZQH1A0A8I5ZQH1_RATNapa299
A0A8I5ZSQ9A0A8I5ZSQ9_RATNapa277

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X89968
EMBL· GenBank· DDBJ
CAA62005.1
EMBL· GenBank· DDBJ
mRNA
BC063156
EMBL· GenBank· DDBJ
AAH63156.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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