P54830 · PTN5_MOUSE

  • Protein
    Tyrosine-protein phosphatase non-receptor type 5
  • Gene
    Ptpn5
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors.

Catalytic activity

Features

Showing features for binding site, active site.

154150100150200250300350400450500
TypeIDPosition(s)Description
Binding site437substrate
Active site472Phosphocysteine intermediate
Binding site472-478substrate
Binding site516substrate

GO annotations

AspectTerm
Cellular Componentaxon
Cellular Componentcell junction
Cellular Componentcytosol
Cellular Componentendoplasmic reticulum membrane
Cellular Componentneuronal cell body
Cellular Componentperikaryon
Cellular Componentplasma membrane
Cellular Componentproximal dendrite
Cellular Componentsynaptic membrane
Cellular Componentsynaptic vesicle
Molecular Functionidentical protein binding
Molecular Functionphosphotyrosine residue binding
Molecular Functionprotein kinase binding
Molecular Functionprotein tyrosine phosphatase activity
Biological Processexploration behavior
Biological Processpositive regulation of long-term synaptic potentiation
Biological Processpositive regulation of neuron projection development
Biological Processpositive regulation of protein import into nucleus
Biological Processpositive regulation of protein phosphorylation
Biological Processpositive regulation of protein targeting to mitochondrion
Biological Processpositive regulation of receptor internalization
Biological Processpositive regulation of response to drug
Biological Processregulation of neuron apoptotic process
Biological Processresponse to immobilization stress
Biological Processsignal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Tyrosine-protein phosphatase non-receptor type 5
  • EC number
  • Alternative names
    • Neural-specific protein-tyrosine phosphatase
    • Striatum-enriched protein-tyrosine phosphatase (STEP)

Gene names

    • Name
      Ptpn5

Organism names

  • Taxonomic identifier
  • Strains
    • BALB/cJ
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P54830
  • Secondary accessions
    • Q64694
    • Q8CAN0

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane64-84Helical
Transmembrane122-142Helical

Keywords

Phenotypes & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 21 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Chemistry

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000947561-541Tyrosine-protein phosphatase non-receptor type 5
Modified residue221Phosphoserine; by PKA
Modified residue231Phosphothreonine; by MAPK
Modified residue244Phosphoserine; by MAPK

Post-translational modification

Phosphorylation at Ser-221 by PKA deactivates PTPN5. Phosphorylation at Thr-231 and Ser-244 by MAPKs stabilizes the phosphatase, dephosphorylation of these sites results in ubiquitin-mediated degradation of the active phosphatase (By similarity).

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

STEP20 is expressed only in the CNS.

Gene expression databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
XENO P54830-1MAPK14 Q16539-16EBI-16067443, EBI-15834191

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region1-55Disordered
Compositional bias29-47Pro residues
Domain276-531Tyrosine-protein phosphatase

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (4)
  • Sequence status
    Complete

This entry describes 4 isoforms produced by Alternative splicing. Additional isoforms seem to exist.

P54830-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    STEP61
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    541
  • Mass (Da)
    60,815
  • Last updated
    2009-02-10 v2
  • Checksum
    31A0D2C9139F90A4
MCCSERLLGLPQPVEMEAPDEAEGLPSKQKEMPPPPPPSPPSEPAQKLPPQGAGSHSLTVRSSLCLFAASQFLLACGVLWLSGHGHSWLQNTTDLISSSLTVLNHLGPVAWLGSGTWGIPSLLLVSLTVSLVIVTTLVWHLLKAPPEPPAPLPPEDRRQSVSRQPSFTYSEWMEEKVEDDFLDLDAVPETPVFDCVMDIKPETDPASLTVKSMGLQERRGSNVSLTLDMCTPGCNEEGFGYLVSPREESAHEYLLSASRVLRAEELHEKALDPFLLQAEFFEIPMNFVDPKEYDIPGLVRKNRYKTILPNPHSRVRLTSPDPEDPLSSYINANYIRGYSGEEKVYIATQGPIVSTVADFWRMVWQERTPIIVMITNIEEMNEKCTEYWPEEQVVHDGVEITVQKVIHTEDYRLRLISLRRGTEERSLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEGPHCSPIIVHCSAGIGRTGCFIATSICCQQLRREGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHAMSLYEKQLSLQSSE

P54830-2

  • Name
    STEP46
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

P54830-3

  • Name
    STEP38
  • Note
    Lacks the catalytic domain.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

P54830-4

  • Name
    STEP20
  • Note
    Lacks the catalytic domain.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Features

Showing features for alternative sequence, compositional bias, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_0051261-172in isoform STEP20 and isoform STEP46
Compositional bias29-47Pro residues
Alternative sequenceVSP_005127337-346in isoform STEP38 and isoform STEP20
Alternative sequenceVSP_005128347-541in isoform STEP38 and isoform STEP20
Sequence conflict426in Ref. 1; AAA73574

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U28217
EMBL· GenBank· DDBJ
AAA73574.1
EMBL· GenBank· DDBJ
mRNA
U28216
EMBL· GenBank· DDBJ
AAA73573.1
EMBL· GenBank· DDBJ
mRNA
S80329
EMBL· GenBank· DDBJ
AAB35656.2
EMBL· GenBank· DDBJ
mRNA
AK038416
EMBL· GenBank· DDBJ
BAC29993.1
EMBL· GenBank· DDBJ
mRNA
CH466603
EMBL· GenBank· DDBJ
EDL22958.1
EMBL· GenBank· DDBJ
Genomic DNA
BC079592
EMBL· GenBank· DDBJ
AAH79592.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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