P54829 · PTN5_HUMAN
- ProteinTyrosine-protein phosphatase non-receptor type 5
- GenePTPN5
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids565 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Catalytic activity
- H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 461 | substrate | ||||
Sequence: D | ||||||
Active site | 496 | Phosphocysteine intermediate | ||||
Sequence: C | ||||||
Binding site | 496-502 | substrate | ||||
Sequence: CSAGIGR | ||||||
Binding site | 540 | substrate | ||||
Sequence: Q |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cell junction | |
Cellular Component | cytosol | |
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | membrane | |
Cellular Component | nucleoplasm | |
Cellular Component | plasma membrane | |
Molecular Function | phosphotyrosine residue binding | |
Molecular Function | protein kinase binding | |
Molecular Function | protein tyrosine phosphatase activity | |
Biological Process | protein dephosphorylation | |
Biological Process | signal transduction |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTyrosine-protein phosphatase non-receptor type 5
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionP54829
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 88-108 | Helical | ||||
Sequence: LCLFAASQFLLACGVLWFSGY | ||||||
Transmembrane | 146-166 | Helical | ||||
Sequence: LLLVFLSVGLVLVTTLVWHLL |
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_054369 | 170 | in dbSNP:rs4757707 | |||
Sequence: P → A | ||||||
Natural variant | VAR_054370 | 561 | in dbSNP:rs11024773 | |||
Sequence: H → R |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 609 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000363657 | 1-565 | Tyrosine-protein phosphatase non-receptor type 5 | |||
Sequence: MNYEGARSERENHAADDSEGGALDMCCSERLPGLPQPIVMEALDEAEGLQDSQREMPPPPPPSPPSDPAQKPPPRGAGSHSLTVRSSLCLFAASQFLLACGVLWFSGYGHIWSQNATNLVSSLLTLLKQLEPTAWLDSGTWGVPSLLLVFLSVGLVLVTTLVWHLLRTPPEPPTPLPPEDRRQSVSRQPSFTYSEWMEEKIEDDFLDLDPVPETPVFDCVMDIKPEADPTSLTVKSMGLQERRGSNVSLTLDMCTPGCNEEGFGYLMSPREESAREYLLSASRVLQAEELHEKALDPFLLQAEFFEIPMNFVDPKEYDIPGLVRKNRYKTILPNPHSRVCLTSPDPDDPLSSYINANYIRGYGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNEKCTEYWPEEQVAYDGVEITVQKVIHTEDYRLRLISLKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEGPHCAPIIVHCSAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLYEKQLSHQSPE | ||||||
Modified residue | 245 | Phosphoserine; by PKA | ||||
Sequence: S | ||||||
Modified residue | 255 | Phosphothreonine; by MAPK | ||||
Sequence: T | ||||||
Modified residue | 268 | Phosphoserine; by MAPK | ||||
Sequence: S |
Post-translational modification
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P54829 | CLEC4G Q6UXB4 | 3 | EBI-1220572, EBI-2114729 | |
BINARY | P54829 | CXCL9 Q07325 | 3 | EBI-1220572, EBI-3911467 | |
BINARY | P54829 | CYB561D2 O14569 | 3 | EBI-1220572, EBI-717654 | |
BINARY | P54829 | ENTPD3 O75355-2 | 3 | EBI-1220572, EBI-12279764 | |
BINARY | P54829 | MARCHF5 Q9NX47 | 3 | EBI-1220572, EBI-2341610 | |
BINARY | P54829 | SLC35B1 P78383 | 3 | EBI-1220572, EBI-12147661 | |
BINARY | P54829 | TERF1 P54274 | 2 | EBI-1220572, EBI-710997 | |
BINARY | P54829 | TMEM201 Q5SNT2-2 | 3 | EBI-1220572, EBI-11994282 | |
BINARY | P54829 | TMEM51 Q9BSA0 | 3 | EBI-1220572, EBI-10297449 | |
BINARY | P54829 | TMEM51 Q9NW97 | 3 | EBI-1220572, EBI-726044 | |
BINARY | P54829 | VTI1B Q9UEU0 | 4 | EBI-1220572, EBI-723716 |
Protein-protein interaction databases
Chemistry
Miscellaneous
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-18 | Basic and acidic residues | ||||
Sequence: MNYEGARSERENHAADDS | ||||||
Region | 1-80 | Disordered | ||||
Sequence: MNYEGARSERENHAADDSEGGALDMCCSERLPGLPQPIVMEALDEAEGLQDSQREMPPPPPPSPPSDPAQKPPPRGAGSH | ||||||
Compositional bias | 54-72 | Pro residues | ||||
Sequence: REMPPPPPPSPPSDPAQKP | ||||||
Region | 169-189 | Disordered | ||||
Sequence: PPEPPTPLPPEDRRQSVSRQP | ||||||
Domain | 300-555 | Tyrosine-protein phosphatase | ||||
Sequence: LQAEFFEIPMNFVDPKEYDIPGLVRKNRYKTILPNPHSRVCLTSPDPDDPLSSYINANYIRGYGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNEKCTEYWPEEQVAYDGVEITVQKVIHTEDYRLRLISLKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEGPHCAPIIVHCSAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLY |
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing.
P54829-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- SynonymsSTEP61
- Length565
- Mass (Da)63,538
- Last updated2011-01-11 v4
- ChecksumDE32BEFFEFF7C494
P54829-2
- Name2
- Differences from canonical
- 98-129: Missing
P54829-3
- Name3
- Differences from canonical
- 1-24: Missing
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Features
Showing features for compositional bias, alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-18 | Basic and acidic residues | ||||
Sequence: MNYEGARSERENHAADDS | ||||||
Alternative sequence | VSP_054561 | 1-24 | in isoform 3 | |||
Sequence: Missing | ||||||
Sequence conflict | 32-34 | in Ref. 6; AAA87555 | ||||
Sequence: PGL → LGR | ||||||
Compositional bias | 54-72 | Pro residues | ||||
Sequence: REMPPPPPPSPPSDPAQKP | ||||||
Alternative sequence | VSP_042654 | 98-129 | in isoform 2 | |||
Sequence: Missing | ||||||
Sequence conflict | 104 | in Ref. 1; BAC03548 | ||||
Sequence: W → R | ||||||
Sequence conflict | 107 | in Ref. 2; CAD38632 | ||||
Sequence: G → A | ||||||
Sequence conflict | 110 | in Ref. 2; CAD38632 | ||||
Sequence: H → D | ||||||
Sequence conflict | 111 | in Ref. 6; AAA87555 | ||||
Sequence: I → M | ||||||
Sequence conflict | 134 | in Ref. 6; AAA87555 | ||||
Sequence: A → S | ||||||
Sequence conflict | 145 | in Ref. 6; AAA87555 | ||||
Sequence: S → G | ||||||
Sequence conflict | 162 | in Ref. 2; CAD38632 | ||||
Sequence: V → L | ||||||
Sequence conflict | 313 | in Ref. 6; AAA87555 | ||||
Sequence: D → V | ||||||
Sequence conflict | 322-323 | in Ref. 6; AAA87555 | ||||
Sequence: LV → RC | ||||||
Sequence conflict | 541 | in Ref. 6; AAA87555 | ||||
Sequence: T → H |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK090923 EMBL· GenBank· DDBJ | BAC03548.1 EMBL· GenBank· DDBJ | mRNA | ||
AK127312 EMBL· GenBank· DDBJ | BAG54479.1 EMBL· GenBank· DDBJ | mRNA | ||
AK295604 EMBL· GenBank· DDBJ | BAH12122.1 EMBL· GenBank· DDBJ | mRNA | ||
AK316270 EMBL· GenBank· DDBJ | BAH14641.1 EMBL· GenBank· DDBJ | mRNA | ||
AL832541 EMBL· GenBank· DDBJ | CAD38632.2 EMBL· GenBank· DDBJ | mRNA | ||
AC103974 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471064 EMBL· GenBank· DDBJ | EAW68363.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471064 EMBL· GenBank· DDBJ | EAW68365.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471064 EMBL· GenBank· DDBJ | EAW68367.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC064807 EMBL· GenBank· DDBJ | AAH64807.1 EMBL· GenBank· DDBJ | mRNA | ||
U27831 EMBL· GenBank· DDBJ | AAA87555.1 EMBL· GenBank· DDBJ | mRNA |