P54784 · ORC1_YEAST
- ProteinOrigin recognition complex subunit 1
- GeneORC1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids914 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication.
Miscellaneous
Present with 3930 molecules/cell in log phase SD medium.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 435 | ATP (UniProtKB | ChEBI) | ||||
Sequence: V | ||||||
Binding site | 479-487 | ATP (UniProtKB | ChEBI) | ||||
Sequence: GTPGVGKTL | ||||||
Binding site | 566 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 567 | ATP (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 567 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 600 | ATP (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 704 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 726-733 | ATP (UniProtKB | ChEBI) | ||||
Sequence: GYGYDGKT |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | DNA replication preinitiation complex | |
Cellular Component | nuclear origin of replication recognition complex | |
Cellular Component | nuclear pre-replicative complex | |
Cellular Component | nucleoplasm | |
Cellular Component | nucleus | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | chromatin binding | |
Molecular Function | DNA replication origin binding | |
Molecular Function | metal ion binding | |
Molecular Function | nucleosome binding | |
Biological Process | DNA replication initiation | |
Biological Process | maintenance of rDNA | |
Biological Process | mitotic DNA replication checkpoint signaling | |
Biological Process | nucleosome organization | |
Biological Process | pre-replicative complex assembly involved in nuclear cell cycle DNA replication | |
Biological Process | silent mating-type cassette heterochromatin formation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameOrigin recognition complex subunit 1
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionP54784
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000127074 | 1-914 | Origin recognition complex subunit 1 | |||
Sequence: MAKTLKDLQGWEIITTDEQGNIIDGGQKRLRRRGAKTEHYLKRSSDGIKLGRGDSVVMHNEAAGTYSVYMIQELRLNTLNNVVELWALTYLRWFEVNPLAHYRQFNPDANILNRPLNYYNKLFSETANKNELYLTAELAELQLFNFIRVANVMDGSKWEVLKGNVDPERDFTVRYICEPTGEKFVDINIEDVKAYIKKVEPREAQEYLKDLTLPSKKKEIKRGPQKKDKATQTAQISDAETRATDITDNEDGNEDESSDYESPSDIDVSEDMDSGEISADELEEEEDEEEDEDEEEKEARHTNSPRKRGRKIKLGKDDIDASVQPPPKKRGRKPKDPSKPRQMLLISSCRANNTPVIRKFTKKNVARAKKKYTPFSKRFKSIAAIPDLTSLPEFYGNSSELMASRFENKLKTTQKHQIVETIFSKVKKQLNSSYVKEEILKSANFQDYLPARENEFASIYLSAYSAIESDSATTIYVAGTPGVGKTLTVREVVKELLSSSAQREIPDFLYVEINGLKMVKPTDCYETLWNKVSGERLTWAASMESLEFYFKRVPKNKKKTIVVLLDELDAMVTKSQDIMYNFFNWTTYENAKLIVIAVANTMDLPERQLGNKITSRIGFTRIMFTGYTHEELKNIIDLRLKGLNDSFFYVDTKTGNAILIDAAGNDTTVKQTLPEDVRKVRLRMSADAIEIASRKVASVSGDARRALKVCKRAAEIAEKHYMAKHGYGYDGKTVIEDENEEQIYDDEDKDLIESNKAKDDNDDDDDNDGVQTVHITHVMKALNETLNSHVITFMTRLSFTAKLFIYALLNLMKKNGSQEQELGDIVDEIKLLIEVNGSNKFVMEIAKTLFQQGSDNISEQLRIISWDFVLNQLLDAGILFKQTMKNDRICCVKLNISVEEAKRAMNEDETLRNL | ||||||
Modified residue | 237 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Subunit
Component of the origin recognition complex (ORC) composed of at least ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. Interacts with MCM10 and TAH11.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P54784 | ORC4 P54791 | 7 | EBI-12568, EBI-12580 | |
BINARY | P54784 | ORC6 P38826 | 5 | EBI-12568, EBI-12588 | |
BINARY | P54784 | SIR1 P21691 | 3 | EBI-12568, EBI-17211 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 48-188 | BAH | ||||
Sequence: IKLGRGDSVVMHNEAAGTYSVYMIQELRLNTLNNVVELWALTYLRWFEVNPLAHYRQFNPDANILNRPLNYYNKLFSETANKNELYLTAELAELQLFNFIRVANVMDGSKWEVLKGNVDPERDFTVRYICEPTGEKFVDIN | ||||||
Region | 218-343 | Disordered | ||||
Sequence: KEIKRGPQKKDKATQTAQISDAETRATDITDNEDGNEDESSDYESPSDIDVSEDMDSGEISADELEEEEDEEEDEDEEEKEARHTNSPRKRGRKIKLGKDDIDASVQPPPKKRGRKPKDPSKPRQM | ||||||
Compositional bias | 249-296 | Acidic residues | ||||
Sequence: NEDGNEDESSDYESPSDIDVSEDMDSGEISADELEEEEDEEEDEDEEE | ||||||
Compositional bias | 311-331 | Basic and acidic residues | ||||
Sequence: KIKLGKDDIDASVQPPPKKRG |
Domain
The N-terminus is dedicated to mating-type repression.
Sequence similarities
Belongs to the ORC1 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length914
- Mass (Da)104,400
- Last updated1996-10-01 v1
- ChecksumBDAA9D3E40B4B76A
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 249-296 | Acidic residues | ||||
Sequence: NEDGNEDESSDYESPSDIDVSEDMDSGEISADELEEEEDEEEDEDEEE | ||||||
Compositional bias | 311-331 | Basic and acidic residues | ||||
Sequence: KIKLGKDDIDASVQPPPKKRG |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U34860 EMBL· GenBank· DDBJ | AAB38248.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z38114 EMBL· GenBank· DDBJ | CAA86256.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BK006946 EMBL· GenBank· DDBJ | DAA09832.1 EMBL· GenBank· DDBJ | Genomic DNA |