P54761 · EPHB4_MOUSE
- ProteinEphrin type-B receptor 4
- GeneEphb4
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids987 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Publications for P54761
Protein tyrosine kinases transcribed in a murine thymic medullary epithelial cell line.
- CategoriesSequences
- SourceMGI: 104757
EGR1 modulates EPHB4-induced trophoblast dysfunction in recurrent spontaneous abortion†.
- AnnotationEGR1 modulates EPHB4-induced trophoblast dysfunction in recurrent spontaneous abortiondagger.
- SourceGeneRif: 13846
Divergent Roles of Ephrin-B2/EphB4 Guidance System in Pulmonary Hypertension.
- AnnotationDivergent Roles of Ephrin-B2/EphB4 Guidance System in Pulmonary Hypertension.
- CategoriesFunction
- SourceGeneRif: 13846
Adaptive activation of EFNB2/EPHB4 axis promotes post-metastatic growth of colorectal cancer liver metastases by LDLR-mediated cholesterol uptake.
- AnnotationAdaptive activation of EFNB2/EPHB4 axis promotes post-metastatic growth of colorectal cancer liver metastases by LDLR-mediated cholesterol uptake.
- CategoriesFunction
- SourceGeneRif: 13846
Insulin induces insulin receptor degradation in the liver through EphB4.
- AnnotationInsulin induces insulin receptor degradation in the liver through EphB4.
- CategoriesFunction, Interaction
- SourceGeneRif: 13846
Delta-like ligand-4 regulates Notch-mediated maturation of second heart field progenitor-derived pharyngeal arterial endothelial cells.
- CategoriesFunction, Expression
- SourceMGI: 104757
EphB4 and ephrinB2 act in opposition in the head and neck tumor microenvironment.
- AnnotationEphB4 and ephrinB2 act in opposition in the head and neck tumor microenvironment.
- CategoriesFunction
Angiogenesis depends upon EPHB4-mediated export of collagen IV from vascular endothelial cells.
- AnnotationAngiogenesis depends upon EPHB4-mediated export of collagen IV from vascular endothelial cells.
- CategoriesFunction, Phenotypes & Variants
Overexpression of EphB4 promotes neurogenesis, but inhibits neuroinflammation in mice with acute ischemic stroke.
- AnnotationOverexpression of EphB4 promotes neurogenesis but inhibits neuroinflammation in mice with acute ischemic stroke.
- CategoriesFunction, Expression
- SourceGeneRif: 13846
Mutations in EPHB4 cause human venous valve aplasia.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 104757
Ligand-Dependent and Ligand-Independent Effects of Ephrin-B2-EphB4 Signaling in Melanoma Metastatic Spine Disease.
- AnnotationLigand-Dependent and Ligand-Independent Effects of Ephrin-B2-EphB4 Signaling in Melanoma Metastatic Spine Disease.
- CategoriesFunction
- SourceGeneRif: 13846
Expression and localisation of ephrin-B1 and EphB4 in steroidogenic cells in the naturally cycling mouse ovary.
- AnnotationExpression and localisation of ephrin-B1 and EphB4 in steroidogenic cells in the naturally cycling mouse ovary.
- CategoriesExpression
- SourceGeneRif: 13846
EphrinB1 modulates glutamatergic inputs into POMC-expressing progenitors and controls glucose homeostasis.
- CategoriesFunction, Expression
- SourceMGI: 104757
Ephrin-B2-EphB4 communication mediates tumor-endothelial cell interactions during hematogenous spread to spinal bone in a melanoma metastasis model.
- AnnotationEphrin-B2-EphB4 communication mediates tumor-endothelial cell interactions during hematogenous spread to spinal bone in a melanoma metastasis model.
- CategoriesFunction
EphrinB2-EphB4 signalling provides Rho-mediated homeostatic control of lymphatic endothelial cell junction integrity.
- AnnotationEphrinB2-EphB4 signalling provides Rho-mediated homeostatic control of lymphatic endothelial cell junction integrity.
- CategoriesFunction, Phenotypes & Variants
Expression and localisation of ephrin-B1, EphB2, and EphB4 in the mouse testis during postnatal development.
- AnnotationExpression and localisation of ephrin-B1 EphB2 and EphB4 in the mouse testis during postnatal development.
- CategoriesExpression
- SourceGeneRif: 13846
Endothelial EphB4 maintains vascular integrity and transport function in adult heart.
- Annotationwe have used mouse genetics imaging and cell biology approaches to investigate how homeostasis in the adult heart is controlled by endothelial EphB4 and its ligand ephrin-B2 which are known regulators of vascular morphogenesis and arteriovenous differentiation during development.
- CategoriesFunction
EPHB4 inhibition activates ER stress to promote immunogenic cell death of prostate cancer cells.
- AnnotationEPHB4 inhibition activates ER stress to promote immunogenic cell death of prostate cancer cells.
- CategoriesFunction
- SourceGeneRif: 13846
Stimulation of Caveolin-1 Signaling Improves Arteriovenous Fistula Patency.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 104757
Venous identity requires BMP signalling through ALK3.
- CategoriesFunction, Interaction
- SourceMGI: 104757