P54687 · BCAT1_HUMAN
- ProteinBranched-chain-amino-acid aminotransferase, cytosolic
- GeneBCAT1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids386 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.
Catalytic activity
- 2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | mitochondrion | |
Molecular Function | branched-chain-amino-acid transaminase activity | |
Molecular Function | L-isoleucine transaminase activity | |
Molecular Function | L-leucine transaminase activity | |
Molecular Function | L-leucine:2-oxoglutarate aminotransferase activity | |
Molecular Function | L-valine transaminase activity | |
Biological Process | branched-chain amino acid biosynthetic process | |
Biological Process | G1/S transition of mitotic cell cycle | |
Biological Process | L-leucine biosynthetic process | |
Biological Process | lipid metabolic process | |
Biological Process | valine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBranched-chain-amino-acid aminotransferase, cytosolic
- EC number
- Short namesBCAT(c)
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionP54687
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_047681 | 59 | in dbSNP:rs17374285 | |||
Sequence: T → M | ||||||
Natural variant | VAR_019614 | 321 | in dbSNP:rs7313020 | |||
Sequence: E → K | ||||||
Natural variant | VAR_047682 | 330 | in dbSNP:rs1057204 | |||
Sequence: G → S |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 522 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for modified residue, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Modified residue | 1 | N-acetylmethionine | ||||
Sequence: M | ||||||
Chain | PRO_0000103292 | 1-386 | Branched-chain-amino-acid aminotransferase, cytosolic | |||
Sequence: MKDCSNGCSAECTGEGGSKEVVGTFKAKDLIVTPATILKEKPDPNNLVFGTVFTDHMLTVEWSSEFGWEKPHIKPLQNLSLHPGSSALHYAVELFEGLKAFRGVDNKIRLFQPNLNMDRMYRSAVRATLPVFDKEELLECIQQLVKLDQEWVPYSTSASLYIRPTFIGTEPSLGVKKPTKALLFVLLSPVGPYFSSGTFNPVSLWANPKYVRAWKGGTGDCKMGGNYGSSLFAQCEAVDNGCQQVLWLYGEDHQITEVGTMNLFLYWINEDGEEELATPPLDGIILPGVTRRCILDLAHQWGEFKVSERYLTMDDLTTALEGNRVREMFGSGTACVVCPVSDILYKGETIHIPTMENGPKLASRILSKLTDIQYGREESDWTIVLS | ||||||
Modified residue | 222 | N6-(pyridoxal phosphate)lysine | ||||
Sequence: K |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
During embryogenesis, expressed in the brain and kidney. Overexpressed in MYC-induced tumors such as Burkitt's lymphoma.
Gene expression databases
Organism-specific databases
Interaction
Subunit
Homodimer.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P54687-4 | CASP6 P55212 | 3 | EBI-25834445, EBI-718729 | |
BINARY | P54687-4 | DNAJB6 O75190-2 | 3 | EBI-25834445, EBI-12593112 | |
BINARY | P54687-4 | DNALI1 O14645 | 3 | EBI-25834445, EBI-395638 | |
BINARY | P54687-4 | FGFR3 P22607 | 3 | EBI-25834445, EBI-348399 | |
BINARY | P54687-4 | GSN P06396 | 3 | EBI-25834445, EBI-351506 | |
BINARY | P54687-4 | KLF11 O14901 | 3 | EBI-25834445, EBI-948266 | |
BINARY | P54687-4 | LAMP2 P13473-2 | 3 | EBI-25834445, EBI-21591415 | |
BINARY | P54687-4 | PRPF40A O75400-2 | 3 | EBI-25834445, EBI-5280197 |
Protein-protein interaction databases
Chemistry
Miscellaneous
Structure
Sequence & Isoforms
- Sequence statusComplete
This entry describes 5 isoforms produced by Alternative splicing.
P54687-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length386
- Mass (Da)42,966
- Last updated2008-11-25 v3
- ChecksumA43535303A702512
P54687-2
- Name2
P54687-3
- Name3
- Differences from canonical
- 94-130: Missing
P54687-4
- Name4
- Differences from canonical
- 1-2: MK → M
P54687-5
- Name5
- Differences from canonical
- 1-2: MK → MASPLRSAAALARQ
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A087WYF2 | A0A087WYF2_HUMAN | BCAT1 | 225 | ||
F5H2F2 | F5H2F2_HUMAN | BCAT1 | 144 |
Features
Showing features for alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_043560 | 1-2 | in isoform 4 | |||
Sequence: MK → M | ||||||
Alternative sequence | VSP_046057 | 1-2 | in isoform 5 | |||
Sequence: MK → MASPLRSAAALARQ | ||||||
Alternative sequence | VSP_042651 | 1-25 | in isoform 2 | |||
Sequence: MKDCSNGCSAECTGEGGSKEVVGTF → M | ||||||
Sequence conflict | 2 | in Ref. 1; AAB08528 | ||||
Sequence: Missing | ||||||
Sequence conflict | 8 | in Ref. 1; AAB08528 | ||||
Sequence: Missing | ||||||
Alternative sequence | VSP_042652 | 94-130 | in isoform 2 and isoform 3 | |||
Sequence: Missing | ||||||
Sequence conflict | 165 | in Ref. 1; AAB08528 | ||||
Sequence: T → A | ||||||
Sequence conflict | 237 | in Ref. 1; AAB08528 | ||||
Sequence: A → D | ||||||
Sequence conflict | 251 | in Ref. 1; AAB08528 | ||||
Sequence: E → R | ||||||
Sequence conflict | 300 | in Ref. 2; BAH11911 | ||||
Sequence: Q → P | ||||||
Sequence conflict | 317 | in Ref. 2; BAB71129 | ||||
Sequence: T → S |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U21551 EMBL· GenBank· DDBJ | AAB08528.1 EMBL· GenBank· DDBJ | mRNA | ||
AK056255 EMBL· GenBank· DDBJ | BAB71129.1 EMBL· GenBank· DDBJ | mRNA | ||
AK128527 EMBL· GenBank· DDBJ | BAG54689.1 EMBL· GenBank· DDBJ | mRNA | ||
AK294879 EMBL· GenBank· DDBJ | BAH11911.1 EMBL· GenBank· DDBJ | mRNA | ||
AK299088 EMBL· GenBank· DDBJ | BAH12946.1 EMBL· GenBank· DDBJ | mRNA | ||
CR749308 EMBL· GenBank· DDBJ | CAH18163.1 EMBL· GenBank· DDBJ | mRNA | ||
AC023796 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC026310 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC092867 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |