P54675 · PI3K3_DICDI

Function

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentphosphatidylinositol 3-kinase complex
Cellular Componentplasma membrane
Molecular Function1-phosphatidylinositol-3-kinase activity
Molecular Function1-phosphatidylinositol-4-phosphate 3-kinase activity
Molecular FunctionATP binding
Molecular Functionsmall GTPase binding
Biological Processbleb assembly
Biological Processcell motility
Biological Processphosphatidylinositol 3-kinase/protein kinase B signal transduction
Biological Processphosphatidylinositol-3-phosphate biosynthetic process
Biological Processphosphatidylinositol-mediated signaling
Biological Processphosphorylation
Biological Processregulation of chemotaxis
Biological Processresponse to bacterium

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphatidylinositol 3-kinase 3
  • EC number
  • Short names
    PI3-kinase; PI3K; PtdIns-3-kinase

Gene names

    • Name
      pikC
    • Synonyms
      pik3
    • ORF names
      DDB_G0275011

Organism names

Accessions

  • Primary accession
    P54675
  • Secondary accessions
    • Q553Z1
    • Q869X9

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000888241-1697Phosphatidylinositol 3-kinase 3

Proteomic databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias, domain, repeat.

Type
IDPosition(s)Description
Region57-91Disordered
Region169-229Disordered
Compositional bias244-262Polar residues
Region244-279Disordered
Region310-376Disordered
Compositional bias311-376Polar residues
Region398-428Disordered
Region440-504Disordered
Domain737-823PI3K-RBD
Domain888-1036C2 PI3K-type
Domain1060-1238PIK helical
Domain1304-1581PI3K/PI4K catalytic
Region1310-1316G-loop
Region1447-1455Catalytic loop
Region1466-1492Activation loop
Compositional bias1609-1628Polar residues
Region1609-1697Disordered
Repeat1622-16261
Region1622-16515 X 5 AA approximate repeats
Repeat1627-16312
Compositional bias1629-1697Basic and acidic residues
Repeat1632-16363
Repeat1642-16464
Repeat1647-16515
Region1659-16727 X 2 AA tandem repeats of K-E

Sequence similarities

Belongs to the PI3/PI4-kinase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,697
  • Mass (Da)
    192,942
  • Last updated
    2007-12-04 v2
  • Checksum
    C5442DC2C3202E32
MRQIVTGVIHQTTQSQQIPNVINSNQIQFSNEPMVVGSIEDFDIDSEVPPLAINLQRSINNNNNNNNNNNNNNNNNNNNNNNNNNNNTQPCTTVFLDRDSCVNVKATIDLLKEQLEFTIKDLIDFKENYDKLESTEQFKQWSNLIKNIKENSLNNSNIYLTIPTTQNLINNNNNNNNNNNNNNNNNNNNNNNNNNNVIIPSASTENKEENDNNNSNNNNNINLSPDSSITKDINITENKITEIKTTETKETSTGTSPLEKSPSKGFIISPKKPEEENEIEGETINNIAITNYTQGPSMLTLMKKKLENIKKNNNNNNNNGNGNNNSNNNNSNSNNNNNGISPSSSPPSHLNGNNNNNNSNNTNSNNTTNATTNSVGFSITMTNSNSLSVSKRMNKFKSWTSSKPTSSSIGFASSPQNNGKPLNISGSSRFFTSRQDSKIDLLKSPSSSPPTQSDIFNENNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNEELINNNNNNNNDENYKIEETEESLKELLEKEKLENEEREKILKERNEIDNLKKKNHLSKGYFMRACNASNDDGLEEEDIPLQDEHWETNVIVLLPCRHHVKVPGSSSSSIDSIRQLAWASGKMQGHLNLEKDEKFFTLRWCNKDVVFDQDTPLGHLIQYNLNYNNPTQKPTNIKLELVLEDELCKERLVDLQSLEINNGRPSIWKSHIDDVLSFNRKLRELAMLAKPQSNVPAARLTPYPPPKTIPEFFVIRVHLFKNQTKSLRCANNHTAFSLMTILSEKLKNTTPFDPTQYRFLITGINQYVDPNVPLLSVEYIVEKIKRKGEIDLTMVELLSLGLIIQQQQQQQQQQQQQQQQQQIENIDDENILKLNNGILNVLSKIEKPIREKDNCISSLTVTENLQVRLLHAHEIFASKASEIIGTDSPSIQLFIEAAVYFGGELLATQSSKLVSFQDTVVWNEWVNIPLAVSNIPNGARMCLGLNARYRGDIFNIGWVGHRLFDSKGILNTFAPFSLLLWPGKINPIGTCVDNLESKDQAIIIAFEFKDYVVPKTIHYEDDLIELISKDENGNELPVVTMEEMDRVEQIILQDPLYSLNKEERLLIWKSRYFCHTKPQALSKLLQSVEWTNYKQVGEAFQLLKIWPTLSAVDALELLDPKFADCVEIREYAVKCLDQMSDYELEIYMLQLVQAIKHDVFHNSVLSLFLIGRVWQNMQVLGHPFFWHLRADIDNQEVCERFRVLSSGFLRYAPTQLMESFKREITTLRILENLAKRVKEVPYEKRKQYVENNLREEQSFPTELFVPFDPSIRILNIIPEKCKSMDSAKVPLWVTFKNADPFAPPLQMIAKTGDDLRQDILTLQLLRLMDHMWKSQDLDLHMTIYRCIATGMGTGLIEVVPNSETAARIQAGAGGVSGAFKQTPIANWLKNHNQTENSYQKAVSKFTLSCAGYCVATYVLGIGDRHNDNIMVDIHGHLFHIDFGHFLGNFKTFAGFQREKAPFVLTPDFVYVIGGKDSPNFAFFVDICCKAFNIIRSNAHVFINMFELMLSTGIPELRSENDIVYLRDKFRLDLTDAEASEYFKKLIHESIGTLTTTINFAIHIMAHRKNLVSGNSAPKIGSASSLNLNKNKPSSQSKLDLSRSDLSRSDSSRSDSSRLDLSRSDKKNNKDNKEKEKEKEKEKEKENNDNNDKDNNNNSNNDTEKENSIDK

Features

Showing features for compositional bias, sequence conflict.

Type
IDPosition(s)Description
Compositional bias244-262Polar residues
Compositional bias311-376Polar residues
Sequence conflict1159in Ref. 3; AAA85723
Sequence conflict1175in Ref. 3; AAA85723
Compositional bias1609-1628Polar residues
Compositional bias1629-1697Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAFI02000013
EMBL· GenBank· DDBJ
EAL69786.1
EMBL· GenBank· DDBJ
Genomic DNA
U23478
EMBL· GenBank· DDBJ
AAA85723.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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