P54675 · PI3K3_DICDI
- ProteinPhosphatidylinositol 3-kinase 3
- GenepikC
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1697 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H+
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | phosphatidylinositol 3-kinase complex | |
Cellular Component | plasma membrane | |
Molecular Function | 1-phosphatidylinositol-3-kinase activity | |
Molecular Function | 1-phosphatidylinositol-4-phosphate 3-kinase activity | |
Molecular Function | ATP binding | |
Molecular Function | small GTPase binding | |
Biological Process | bleb assembly | |
Biological Process | cell motility | |
Biological Process | phosphatidylinositol 3-kinase/protein kinase B signal transduction | |
Biological Process | phosphatidylinositol-3-phosphate biosynthetic process | |
Biological Process | phosphatidylinositol-mediated signaling | |
Biological Process | phosphorylation | |
Biological Process | regulation of chemotaxis | |
Biological Process | response to bacterium |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphatidylinositol 3-kinase 3
- EC number
- Short namesPI3-kinase; PI3K; PtdIns-3-kinase
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Amoebozoa > Evosea > Eumycetozoa > Dictyostelia > Dictyosteliales > Dictyosteliaceae > Dictyostelium
Accessions
- Primary accessionP54675
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000088824 | 1-1697 | Phosphatidylinositol 3-kinase 3 | ||
Proteomic databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain, repeat.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 57-91 | Disordered | |||
Region | 169-229 | Disordered | |||
Compositional bias | 244-262 | Polar residues | |||
Region | 244-279 | Disordered | |||
Region | 310-376 | Disordered | |||
Compositional bias | 311-376 | Polar residues | |||
Region | 398-428 | Disordered | |||
Region | 440-504 | Disordered | |||
Domain | 737-823 | PI3K-RBD | |||
Domain | 888-1036 | C2 PI3K-type | |||
Domain | 1060-1238 | PIK helical | |||
Domain | 1304-1581 | PI3K/PI4K catalytic | |||
Region | 1310-1316 | G-loop | |||
Region | 1447-1455 | Catalytic loop | |||
Region | 1466-1492 | Activation loop | |||
Compositional bias | 1609-1628 | Polar residues | |||
Region | 1609-1697 | Disordered | |||
Repeat | 1622-1626 | 1 | |||
Region | 1622-1651 | 5 X 5 AA approximate repeats | |||
Repeat | 1627-1631 | 2 | |||
Compositional bias | 1629-1697 | Basic and acidic residues | |||
Repeat | 1632-1636 | 3 | |||
Repeat | 1642-1646 | 4 | |||
Repeat | 1647-1651 | 5 | |||
Region | 1659-1672 | 7 X 2 AA tandem repeats of K-E | |||
Sequence similarities
Belongs to the PI3/PI4-kinase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,697
- Mass (Da)192,942
- Last updated2007-12-04 v2
- ChecksumC5442DC2C3202E32
Features
Showing features for compositional bias, sequence conflict.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 244-262 | Polar residues | |||
Compositional bias | 311-376 | Polar residues | |||
Sequence conflict | 1159 | in Ref. 3; AAA85723 | |||
Sequence conflict | 1175 | in Ref. 3; AAA85723 | |||
Compositional bias | 1609-1628 | Polar residues | |||
Compositional bias | 1629-1697 | Basic and acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AAFI02000013 EMBL· GenBank· DDBJ | EAL69786.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U23478 EMBL· GenBank· DDBJ | AAA85723.1 EMBL· GenBank· DDBJ | mRNA |