No title available.Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.Cited forNUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]CategorySequencesSourceUniProtKB reviewed (Swiss-Prot)Submission Submitted to EMBL/GenBank/DDBJ databases (JUL-2005)Cited in99+20
Mammalian AMP-activated protein kinase subfamily.Stapleton D., Mitchelhill K.I., Gao G., Widmer J., Michell B.J., Teh T., House C.M., Fernandez C.S., Cox T.[...], Kemp B.E.View abstractCited forNUCLEOTIDE SEQUENCE [MRNA] OF 10-559, PROTEIN SEQUENCE OF 24-40; 90-115; 129-140; 150-160; 166-182; 236-257; 272-276; 286-305; 326-341; 350-367; 375-384; 409-426; 437-446; 458-475 AND 507-517StrainSprague-DawleyTissueHypothalamus, LiverCategorySequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 271:611-614 (1996)Cited in3
Regulation of HMG-CoA reductase: identification of the site phosphorylated by the AMP-activated protein kinase in vitro and in intact rat liver.Clarke P.R., Hardie D.G.View abstractCited forCATALYTIC ACTIVITY, FUNCTION IN PHOSPHORYLATION OF HMGCRCategoriesFunction, PTM / ProcessingSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCEMBO J. 9:2439-2446 (1990)Cited in3
Mammalian 5'-AMP-activated protein kinase non-catalytic subunits are homologs of proteins that interact with yeast Snf1 protein kinase.Stapleton D., Gao G., Michell B.J., Widmer J., Mitchelhill K.I., Teh T., House C.M., Witters L.A., Kemp B.E.View abstractCited forIDENTIFICATION IN THE AMPK COMPLEXStrainSprague-DawleyTissueHypothalamus, LiverCategoryInteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 269:29343-29346 (1994)Cited in5
Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase.Hawley S.A., Davison M., Woods A., Davies S.P., Beri R.K., Carling D., Hardie D.G.View abstractCited forPHOSPHORYLATION AT THR-183, ACTIVITY REGULATIONCategoriesPTM / Processing, FunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 271:27879-27887 (1996)Cited in2
Phosphorylation of rat muscle acetyl-CoA carboxylase by AMP-activated protein kinase and protein kinase A.Winder W.W., Wilson H.A., Hardie D.G., Rasmussen B.B., Hutber C.A., Call G.B., Clayton R.D., Conley L.M., Yoon S., Zhou B.View abstractCited forCATALYTIC ACTIVITY, FUNCTION IN PHOSPHORYLATION OF ACACA AND ACACBCategoriesFunction, PTM / ProcessingSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Appl. Physiol. 82:219-225 (1997)Cited in3
AMP-activated protein kinase phosphorylation of endothelial NO synthase.Chen Z.P., Mitchelhill K.I., Michell B.J., Stapleton D., Rodriguez-Crespo I., Witters L.A., Power D.A., Ortiz de Montellano P.R., Kemp B.E.View abstractCited forFUNCTION IN PHOSPHORYLATION OF NOS3CategoriesFunction, PTM / ProcessingSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCFEBS Lett. 443:285-289 (1999)Cited in3
Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia.Marsin A.S., Bertrand L., Rider M.H., Deprez J., Beauloye C., Vincent M.F., Van den Berghe G., Carling D., Hue L.View abstractCited forFUNCTION IN PHOSPHORYLATION OF PFKFB2CategoriesFunction, PTM / ProcessingSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCCurr. Biol. 10:1247-1255 (2000)Cited in3Mapped to6
5'-AMP-activated protein kinase phosphorylates IRS-1 on Ser-789 in mouse C2C12 myotubes in response to 5-aminoimidazole-4-carboxamide riboside.Jakobsen S.N., Hardie D.G., Morrice N., Tornqvist H.E.View abstractCited forFUNCTION IN PHOSPHORYLATION OF IRS1CategoriesFunction, PTM / ProcessingSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 276:46912-46916 (2001)Cited in3
Mechanism for fatty acid 'sparing' effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase.Kawaguchi T., Osatomi K., Yamashita H., Kabashima T., Uyeda K.View abstractCited forFUNCTION IN PHOSPHORYLATION OF MLXIPLCategoriesFunction, PTM / ProcessingSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 277:3829-3835 (2002)Cited in3Mapped to11
The stimulation of glycolysis by hypoxia in activated monocytes is mediated by AMP-activated protein kinase and inducible 6-phosphofructo-2- kinase.Marsin A.S., Bouzin C., Bertrand L., Hue L.View abstractCited forFUNCTION IN PHOSPHORYLATION OF PFKFB3CategoriesFunction, PTM / ProcessingSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 277:30778-30783 (2002)Cited in3
LKB1 is the upstream kinase in the AMP-activated protein kinase cascade.Woods A., Johnstone S.R., Dickerson K., Leiper F.C., Fryer L.G., Neumann D., Schlattner U., Wallimann T., Carlson M., Carling D.View abstractCited forPHOSPHORYLATION AT THR-183, ACTIVITY REGULATIONCategoriesPTM / Processing, FunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCCurr. Biol. 13:2004-2008 (2003)Cited in2Mapped to12
Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade.Hawley S.A., Boudeau J., Reid J.L., Mustard K.J., Udd L., Makela T.P., Alessi D.R., Hardie D.G.View abstractCited forFUNCTION, ACTIVITY REGULATION, PHOSPHORYLATION AT THR-183CategoriesFunction, PTM / ProcessingSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. 2:28.1-28.16 (2003)Cited in4Mapped to30
AMP-activated protein kinase regulates HNF4alpha transcriptional activity by inhibiting dimer formation and decreasing protein stability.Hong Y.H., Varanasi U.S., Yang W., Leff T.View abstractCited forFUNCTION IN PHOSPHORYLATION OF HNF4ACategoriesFunction, PTM / ProcessingSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 278:27495-27501 (2003)Cited in3
Identification of phosphorylation sites in AMP-activated protein kinase (AMPK) for upstream AMPK kinases and study of their roles by site-directed mutagenesis.Woods A., Vertommen D., Neumann D., Turk R., Bayliss J., Schlattner U., Wallimann T., Carling D., Rider M.H.View abstractCited forPHOSPHORYLATION AT THR-269 AND SER-496, MUTAGENESIS OF THR-183; THR-269 AND SER-496, IDENTIFICATION BY MASS SPECTROMETRYCategoriesPTM / Processing, Sequences, Phenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 278:28434-28442 (2003)Cited in3Mapped to2
Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398.Browne G.J., Finn S.G., Proud C.G.View abstractCited forFUNCTION IN PHOSPHORYLATION OF EEF2KCategoriesFunction, PTM / ProcessingSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 279:12220-12231 (2004)Cited in3Mapped to14
Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase.Hawley S.A., Pan D.A., Mustard K.J., Ross L., Bain J., Edelman A.M., Frenguelli B.G., Hardie D.G.View abstractCited forPHOSPHORYLATION AT THR-183, ACTIVITY REGULATIONCategoriesPTM / Processing, FunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCCell Metab. 2:9-19 (2005)Cited in4Mapped to22
Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP- activated protein kinase in mammalian cells.Woods A., Dickerson K., Heath R., Hong S.-P., Momcilovic M., Johnstone S.R., Carlson M., Carling D.View abstractCited forPHOSPHORYLATION AT THR-183, ACTIVITY REGULATIONCategoriesPTM / Processing, FunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCCell Metab. 2:21-33 (2005)Cited in3Mapped to24
Regulation of the renal-specific Na+-K+-2Cl- co-transporter NKCC2 by AMP- activated protein kinase (AMPK).Fraser S.A., Gimenez I., Cook N., Jennings I., Katerelos M., Katsis F., Levidiotis V., Kemp B.E., Power D.A.View abstractCited forFUNCTION IN PHOSPHORYLATION OF SLC12A1CategoriesFunction, PTM / ProcessingSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCBiochem. J. 405:85-93 (2007)Cited in3Mapped to4
Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop.Loffler A.S., Alers S., Dieterle A.M., Keppeler H., Franz-Wachtel M., Kundu M., Campbell D.G., Wesselborg S., Alessi D.R., Stork B.View abstractCited forPHOSPHORYLATION BY ULK1 AND ULK, PHOSPHORYLATION AT SER-360; THR-368; SER-397; SER-486 AND THR-488CategoryPTM / ProcessingSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCAutophagy 7:696-706 (2011)Cited in23Mapped to12
AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid beta-peptide exposure.Thornton C., Bright N.J., Sastre M., Muckett P.J., Carling D.View abstractCited forFUNCTION IN PHOSPHORYLATION OF MAPTCategoriesFunction, PTM / ProcessingSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCBiochem. J. 434:503-512 (2011)Cited in1Mapped to27
Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.View abstractCited forPHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-486; THR-490 AND SER-496, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]CategoriesPTM / Processing, SequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNat. Commun. 3:876-876 (2012)Cited in99+99+
Structural basis for AMP binding to mammalian AMP-activated protein kinase.Xiao B., Heath R., Saiu P., Leiper F.C., Leone P., Jing C., Walker P.A., Haire L., Eccleston J.F.[...], Gamblin S.J.View abstractCited forX-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 405-557 IN COMPLEX WITH PRKAB2 AND PRKAG1CategoriesInteraction, StructureSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNature 449:496-500 (2007)Cited in3Mapped to5
Structure of mammalian AMPK and its regulation by ADP.Xiao B., Sanders M.J., Underwood E., Heath R., Mayer F.V., Carmena D., Jing C., Walker P.A., Eccleston J.F.[...], Gamblin S.J.View abstractCited forX-RAY CRYSTALLOGRAPHY (2.51 ANGSTROMS) OF 13-559 IN COMPLEX WITH PRKAB2 AND PRKAG1, MUTAGENESIS OF 386-ARG--GLU-391CategoriesInteraction, Phenotypes & Variants, StructureSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNature 472:230-233 (2011)Cited in3Mapped to5
Posttranslational modifications of the 5'-AMP-activated protein kinase beta1 subunit.Mitchelhill K.I., Michell B.J., House C.M., Stapleton D., Dyck J., Gamble J., Ullrich C., Witters L.A., Kemp B.E.View abstractCategoryPTM / ProcessingSourcePhosphoSitePlus: P54645PubMedEurope PMCJ. Biol. Chem. 272:24475-24479 (1997)Cited in1Mapped to1