P54631 · SCW_DROME

Function

function

Part of the signal that specifies dorsal cell fates in the embryo. Acts together with dpp.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular space
Molecular Functioncytokine activity
Molecular Functiongrowth factor activity
Molecular Functionprotein heterodimerization activity
Molecular Functionreceptor ligand activity
Biological Processamnioserosa formation
Biological ProcessBMP signaling pathway
Biological Processcell differentiation
Biological Processdigestive tract mesoderm development
Biological Processdorsal/ventral pattern formation
Biological Processgonad development
Biological Processimaginal disc-derived wing morphogenesis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein screw

Gene names

    • Name
      scw
    • ORF names
      CG31695

Organism names

  • Taxonomic identifier
  • Strains
    • Canton-S
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    P54631
  • Secondary accessions
    • Q8INV8

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, propeptide, glycosylation, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-16
PropeptidePRO_000003367217-277
Glycosylation165N-linked (GlcNAc...) asparagine
Glycosylation189N-linked (GlcNAc...) asparagine
Glycosylation201N-linked (GlcNAc...) asparagine
ChainPRO_0000033673278-400Protein screw
Disulfide bond300↔365
Glycosylation304N-linked (GlcNAc...) asparagine
Disulfide bond329↔397
Disulfide bond333↔399
Glycosylation342N-linked (GlcNAc...) asparagine
Disulfide bond364Interchain

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Ubiquitously expressed during early stages of embryogenesis, but the effect on development appears graded and is restricted to the dorsal side of the embryo.

Developmental stage

Expressed both maternally and zygotically. Highest embryonic expression is found during syncytial blastoderm (nuclear cycles 11-12). Expression declines rapidly at cellular blastoderm stage 5 and is not detected during the rest of embryonic development.

Gene expression databases

Interaction

Subunit

Heterodimers of scw/dpp are the active subunit, dpp/dpp homodimers elicit a basal response and scw/scw homodimers alone are ineffective in specifying a dorsal pattern.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the TGF-beta family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    400
  • Mass (Da)
    45,891
  • Last updated
    2001-11-02 v2
  • Checksum
    2B42B7D28B9B8336
MLNVFFLTSLFYAASATTYVTTNNHIEMPIYQKRPLSEQMEMIDILDLGDRPRRQAEPNLHNSASKFLLEVYNEISEDQEPKEVLHQRHKRSLDDDILISNEDRQEIASCNSILTFSSRLKPEQLDNELDMHITFNTNDVPVDLSLVQAMLRIYKQPSLVDRRANFTVSVYRKLDNRQDFSYRILGSVNTTSSQRGWLEFNLTDTLRYWLHNKGLQRRNELRISIGDSQLSTFAAGLVTPQASRTSLEPFIVGYFNGPELLVKIQKLRFKRDLEKRRAGGGSPPPPPPPPVDLYRPPQSCERLNFTVDFKELHMHNWVIAPKKFEAYFCGGGCNFPLGTKMNATNHAIVQTLMHLKQPHLPKPCCVPTVLGAITILRYLNEDIIDLTKYQKAVAKECGCH

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
X2JB15X2JB15_DROMEscw400

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict6in Ref. 1; AAA56872

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U17573
EMBL· GenBank· DDBJ
AAA56872.1
EMBL· GenBank· DDBJ
mRNA
AE014134
EMBL· GenBank· DDBJ
AAN11056.2
EMBL· GenBank· DDBJ
Genomic DNA
AY051793
EMBL· GenBank· DDBJ
AAK93217.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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