P54311 · GBB1_RAT
- ProteinGuanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
- GeneGnb1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids340 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGuanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionP54311
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for initiator methionine, modified residue, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Initiator methionine | 1 | Removed | ||||
Sequence: M | ||||||
Modified residue | 2 | N-acetylserine | ||||
Sequence: S | ||||||
Modified residue | 2 | Phosphoserine | ||||
Sequence: S | ||||||
Chain | PRO_0000127690 | 2-340 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | |||
Sequence: SELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN | ||||||
Modified residue | 266 | Phosphohistidine | ||||
Sequence: H |
Post-translational modification
Phosphorylation at His-266 by NDKB contributes to G protein activation by increasing the high energetic phosphate transfer onto GDP.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Subunit
G proteins are composed of 3 units, alpha, beta and gamma (By similarity).
The heterodimer formed by GNB1 and GNG2 interacts with ARHGEF5 (By similarity).
The heterodimer formed by GNB1 and GNG2 interacts with GRK2 (By similarity).
Forms a complex with GNAO1 and GNG3. Interacts with ARHGEF18 and RASD2 (By similarity).
The heterodimer formed by GNB1 and GNG2 interacts with ARHGEF5 (By similarity).
The heterodimer formed by GNB1 and GNG2 interacts with GRK2 (By similarity).
Forms a complex with GNAO1 and GNG3. Interacts with ARHGEF18 and RASD2 (By similarity).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P54311 | Wasf1 Q5BJU7 | 2 | EBI-917779, EBI-7269229 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 53-83 | WD 1 | ||||
Sequence: GHLAKIYAMHWGTDSRLLVSASQDGKLIIWD | ||||||
Repeat | 95-125 | WD 2 | ||||
Sequence: LRSSWVMTCAYAPSGNYVACGGLDNICSIYN | ||||||
Repeat | 141-170 | WD 3 | ||||
Sequence: GHTGYLSCCRFLDDNQIVTSSGDTTCALWD | ||||||
Repeat | 182-212 | WD 4 | ||||
Sequence: GHTGDVMSLSLAPDTRLFVSGACDASAKLWD | ||||||
Repeat | 224-254 | WD 5 | ||||
Sequence: GHESDINAICFFPNGNAFATGSDDATCRLFD | ||||||
Repeat | 268-298 | WD 6 | ||||
Sequence: NIICGITSVSFSKSGRLLLAGYDDFNCNVWD | ||||||
Repeat | 310-340 | WD 7 | ||||
Sequence: GHDNRVSCLGVTDDGMAVATGSWDSFLKIWN |
Sequence similarities
Belongs to the WD repeat G protein beta family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length340
- Mass (Da)37,377
- Last updated2007-01-23 v4
- Checksum896CBD32D2686598
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8I6GEG9 | A0A8I6GEG9_RAT | Gnb1 | 263 |
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 208 | in Ref. 2; AAD00650 | ||||
Sequence: A → V | ||||||
Sequence conflict | 277 | in Ref. 2; AAD00650 | ||||
Sequence: S → P | ||||||
Sequence conflict | 287 | in Ref. 2; AAD00650 | ||||
Sequence: A → G | ||||||
Sequence conflict | 301 | in Ref. 2; AAD00650 | ||||
Sequence: K → N | ||||||
Sequence conflict | 307 | in Ref. 1; AAC72249 | ||||
Sequence: V → D |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U34958 EMBL· GenBank· DDBJ | AAC72249.1 EMBL· GenBank· DDBJ | mRNA | ||
U88324 EMBL· GenBank· DDBJ | AAD00650.1 EMBL· GenBank· DDBJ | mRNA | ||
AY552805 EMBL· GenBank· DDBJ | AAS59143.1 EMBL· GenBank· DDBJ | mRNA | ||
BC078809 EMBL· GenBank· DDBJ | AAH78809.1 EMBL· GenBank· DDBJ | mRNA |