P54311 · GBB1_RAT

  • Protein
    Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
  • Gene
    Gnb1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell body
Cellular Componentcytoplasm
Cellular Componentdendrite
Cellular Componentheterotrimeric G-protein complex
Cellular Componentphotoreceptor inner segment
Cellular Componentphotoreceptor outer segment
Cellular Componentphotoreceptor outer segment membrane
Cellular Componentplasma membrane
Cellular Componentsynapse
Molecular Functionalkylglycerophosphoethanolamine phosphodiesterase activity
Molecular FunctionGTPase activity
Molecular FunctionGTPase binding
Molecular Functionprotein-containing complex binding
Molecular Functionsignaling receptor complex adaptor activity
Molecular Functionspectrin binding
Biological Processcardiac muscle cell apoptotic process
Biological Processcell population proliferation
Biological Processcellular response to hypoxia
Biological ProcessG protein-coupled receptor signaling pathway
Biological Processphospholipase C-activating G protein-coupled receptor signaling pathway
Biological Processpositive regulation of cytosolic calcium ion concentration
Biological Processretina development in camera-type eye
Biological Processsensory perception of taste

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
  • Alternative names
    • Transducin beta chain 1

Gene names

    • Name
      Gnb1

Organism names

  • Taxonomic identifier
  • Strains
    • Sprague-Dawley
    • Wistar
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    P54311
  • Secondary accessions
    • Q6Q8B1
    • Q9QWG8

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for initiator methionine, modified residue, chain.

TypeIDPosition(s)Description
Initiator methionine1Removed
Modified residue2N-acetylserine
Modified residue2Phosphoserine
ChainPRO_00001276902-340Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Modified residue266Phosphohistidine

Post-translational modification

Phosphorylation at His-266 by NDKB contributes to G protein activation by increasing the high energetic phosphate transfer onto GDP.

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

G proteins are composed of 3 units, alpha, beta and gamma (By similarity).
The heterodimer formed by GNB1 and GNG2 interacts with ARHGEF5 (By similarity).
The heterodimer formed by GNB1 and GNG2 interacts with GRK2 (By similarity).
Forms a complex with GNAO1 and GNG3. Interacts with ARHGEF18 and RASD2 (By similarity).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY P54311Wasf1 Q5BJU72EBI-917779, EBI-7269229

Protein-protein interaction databases

Family & Domains

Features

Showing features for repeat.

TypeIDPosition(s)Description
Repeat53-83WD 1
Repeat95-125WD 2
Repeat141-170WD 3
Repeat182-212WD 4
Repeat224-254WD 5
Repeat268-298WD 6
Repeat310-340WD 7

Sequence similarities

Belongs to the WD repeat G protein beta family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    340
  • Mass (Da)
    37,377
  • Last updated
    2007-01-23 v4
  • Checksum
    896CBD32D2686598
MSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8I6GEG9A0A8I6GEG9_RATGnb1263

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict208in Ref. 2; AAD00650
Sequence conflict277in Ref. 2; AAD00650
Sequence conflict287in Ref. 2; AAD00650
Sequence conflict301in Ref. 2; AAD00650
Sequence conflict307in Ref. 1; AAC72249

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U34958
EMBL· GenBank· DDBJ
AAC72249.1
EMBL· GenBank· DDBJ
mRNA
U88324
EMBL· GenBank· DDBJ
AAD00650.1
EMBL· GenBank· DDBJ
mRNA
AY552805
EMBL· GenBank· DDBJ
AAS59143.1
EMBL· GenBank· DDBJ
mRNA
BC078809
EMBL· GenBank· DDBJ
AAH78809.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp