P54283 · CACB1_RAT

  • Protein
    Voltage-dependent L-type calcium channel subunit beta-1
  • Gene
    Cacnb1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Regulatory subunit of L-type calcium channels. Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit (By similarity).
Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane (Probable). Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit. Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentglutamatergic synapse
Cellular Componentpostsynapse
Cellular Componentpresynapse
Cellular Componentsarcoplasmic reticulum
Cellular ComponentT-tubule
Cellular Componentvoltage-gated calcium channel complex
Molecular Functionhigh voltage-gated calcium channel activity
Molecular Functionidentical protein binding
Molecular Functionphosphoprotein binding
Molecular Functionprotein domain specific binding
Molecular Functionprotein kinase binding
Molecular Functionvoltage-gated calcium channel activity
Biological Processcalcium ion transport
Biological Processcellular response to amyloid-beta
Biological Processchemical synaptic transmission
Biological Processneuromuscular junction development
Biological Processprotein targeting to membrane
Biological Processregulation of calcium ion transmembrane transport via high voltage-gated calcium channel

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Voltage-dependent L-type calcium channel subunit beta-1
  • Short names
    CAB1
  • Alternative names
    • Calcium channel voltage-dependent subunit beta 1

Gene names

    • Name
      Cacnb1
    • Synonyms
      Cacnlb1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    P54283

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00001440491-597Voltage-dependent L-type calcium channel subunit beta-1
Modified residue44Phosphoserine
Modified residue47Phosphoserine
Modified residue73Phosphoserine
Modified residue186Phosphoserine
Modified residue193Phosphoserine
Modified residue499Phosphothreonine
Modified residue547Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Detected in brain.

Interaction

Subunit

Regulatory subunit of L-type calcium channels that consist of a pore-forming alpha subunit and auxiliary beta, gamma and delta subunits (PubMed:21127204).
Interacts with CACNA1A, CACNA1B, CACNA1C and CACNA1S (By similarity).
Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1. Identified in a complex with CACNA1C (By similarity).
Identified in a complex with the L-type calcium channel subunits CACNA1C, CACNA2D1, CACNB1 and one of the gamma subunits (CACNG4, CACNG6, CACNG7, or CACNG8) (PubMed:21127204).
Part of a L-type calcium channel complex that contains CACNA1D, CACNA2D1 and CACNB1. Part of a L-type calcium channel complex that contains CACNA1B, CACNA2D1 and CACNB1 (By similarity).
Interacts with JSRP1. Interacts with RYR1 (By similarity).
Interacts with CBARP (PubMed:24751537).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY P54283Cacnb1 P542832EBI-349245, EBI-349245

Protein-protein interaction databases

Chemistry

Structure

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region1-79Disordered
Compositional bias43-69Polar residues
Domain100-169SH3
Compositional bias179-216Polar residues
Region179-223Disordered
Region466-597Disordered
Compositional bias500-514Polar residues

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    597
  • Mass (Da)
    65,680
  • Last updated
    1996-10-01 v1
  • Checksum
    D95BF4982AF1FD5E
MVQKSGMSRGPYPPSQEIPMEVFDPSPQGKYSKRKGRFKRSDGSTSSDTTSNSFVRQGSAESYTSRPSDSDVSLEEDREALRKEAERQALAQLEKAKTKPVAFAVRTNVGYNPSPGDEVPVQGVAITFEPKDFLHIKEKYNNDWWIGRLVKEGCEVGFIPSPVKLDSLRLLQEQTLRQNRLSSSKSGDNSSSSLGDVVTGTRRPTPPASAKQKQKSTEHVPPYDVVPSMRPIILVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKHIIIERSNTRSSLAEVQSEIERIFELARTLQLVALDADTINHPAQLSKTSLAPIIVYIKITSPKVLQRLIKSRGKSQSKHLNVQIAASEKLAQCPPEMFDIILDENQLEDACEHLAEYLEAYWKATHPPSRTPPNPLLNRTMATAALAVSPAPVSNLQGPYLVSGDQPLDRATGEHASVHEYPGELGQPPGLYPSNHPPGRAGTLWALSRQDTFDADTPGSRNSVYTEPGDSCVDMETDPSEGPGPGDPAGGGTPPARQGSWEEEEDYEEEMTDNRNRGRNKARYCAEGGGPVLGRNKNELEGWGQGVYIR

Computationally mapped potential isoform sequences

There are 5 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0G2K4U4A0A0G2K4U4_RATCacnb1642
A0A8I6ASP4A0A8I6ASP4_RATCacnb1595
A0A8I6A459A0A8I6A459_RATCacnb1570
G3V6K8G3V6K8_RATCacnb1597
A0A8I5ZLV2A0A8I5ZLV2_RATCacnb1591

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias43-69Polar residues
Compositional bias179-216Polar residues
Compositional bias500-514Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X61394
EMBL· GenBank· DDBJ
CAA43665.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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