P54282 · CAC1A_RAT
- ProteinVoltage-dependent P/Q-type calcium channel subunit alpha-1A
- GeneCacna1a
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids2212 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by the spider omega-agatoxin-IVA (AC P30288) (PubMed:1311418).
They are however insensitive to dihydropyridines (DHP)
They are however insensitive to dihydropyridines (DHP)
Catalytic activity
- Ca2+(in) = Ca2+(out)
Features
Showing features for binding site, site.
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameVoltage-dependent P/Q-type calcium channel subunit alpha-1A
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionP54282
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-100 | Cytoplasmic | ||||
Sequence: MARFGDEMPGRYGAGGGGSGPAAGVVVGAAGGRGAGGSRQGGQPGAQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAKKITEWP | ||||||
Transmembrane | 101-119 | Helical; Name=S1 of repeat I | ||||
Sequence: PFEYMILATIIANCIVLAL | ||||||
Topological domain | 120-138 | Extracellular | ||||
Sequence: EQHLPDDDKTPMSERLDDT | ||||||
Transmembrane | 139-156 | Helical; Name=S2 of repeat I | ||||
Sequence: EPYFIGIFCFEAGIKIVA | ||||||
Topological domain | 157-168 | Cytoplasmic | ||||
Sequence: LGFAFHKGSYLR | ||||||
Transmembrane | 169-184 | Helical; Name=S3 of repeat I | ||||
Sequence: NGWNVMDFVVVLTGIL | ||||||
Topological domain | 185-192 | Extracellular | ||||
Sequence: ATVGTEFD | ||||||
Transmembrane | 193-211 | Helical; Name=S4 of repeat I | ||||
Sequence: LRTLRAVRVLRPLKLVSGI | ||||||
Topological domain | 212-230 | Cytoplasmic | ||||
Sequence: PSLQVVLKSIMKAMIPLLQ | ||||||
Transmembrane | 231-250 | Helical; Name=S5 of repeat I | ||||
Sequence: IGLLLFFAILIFAIIGLEFY | ||||||
Topological domain | 251-337 | Extracellular | ||||
Sequence: MGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTW | ||||||
Transmembrane | 338-362 | Helical; Name=S6 of repeat I | ||||
Sequence: NWLYFIPLIIIGSFFMLNLVLGVLS | ||||||
Topological domain | 363-489 | Cytoplasmic | ||||
Sequence: GEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDVEQRHPFDGALRRATLKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQ | ||||||
Transmembrane | 490-509 | Helical; Name=S1 of repeat II | ||||
Sequence: AFYWTVLSLVALNTLWLAIV | ||||||
Topological domain | 510-523 | Extracellular | ||||
Sequence: HYNQPEWLSDFLYY | ||||||
Transmembrane | 524-543 | Helical; Name=S2 of repeat II | ||||
Sequence: AEFIFLGLFMSEMFIKMYGL | ||||||
Topological domain | 544-551 | Cytoplasmic | ||||
Sequence: GTRPYFHS | ||||||
Transmembrane | 552-570 | Helical; Name=S3 of repeat II | ||||
Sequence: SFNCFDCGVIIGSIFEVIW | ||||||
Topological domain | 571-580 | Extracellular | ||||
Sequence: AVIKPGTSFG | ||||||
Transmembrane | 581-599 | Helical; Name=S4 of repeat II | ||||
Sequence: ISVLRALRLLRIFKVTKYW | ||||||
Topological domain | 600-618 | Cytoplasmic | ||||
Sequence: ASLRNLVVSLLNSMKSIIS | ||||||
Transmembrane | 619-638 | Helical; Name=S5 of repeat II | ||||
Sequence: LLFLLFLFIVVFALLGMQLF | ||||||
Topological domain | 639-691 | Extracellular | ||||
Sequence: GGQFNFDEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDEIKSQGGVQGGMV | ||||||
Transmembrane | 692-716 | Helical; Name=S6 of repeat II | ||||
Sequence: FSIYFIVLTLFGNYTLLNVFLAIAV | ||||||
Topological domain | 717-1190 | Cytoplasmic | ||||
Sequence: DNLANAQELTKDEQEEEEAANQKLALQKAKEVAEVSPLSAANMSIAVKEQQKNQKPAKSVWEQRTSEMRKQNLLASREALYGDAAERWPTTYARPLRPDVKTHLDRPLVVDPQENRNNNTNKSRAPEALRQTARPRESARDPDARRAWPSSPERAPGREGPYGRESEPQQREHAPPREHVPWDADPERAKAGDAPRRHTHRPVAEGEPRRHRARRRPGDEPDDRPERRPRPRDATRPARAADGEGDDGERKRRHRHGPPAHDDRERRHRRRKESQGSGVPMSGPNLSTTRPIQQDLGRQDLPLAEDLDNMKNNKLATGEPASPHDSLGHSGLPPSPAKIGNSTNPGPALATNPQNAASRRTPNNPGNPSNPGPPKTPENSLIVTNPSSTQPNSAKTARKPEHMAVEIPPACPPLNHTVVQVNKNANPDPLPKKEEEKKEEEEADPGEDGPKPMPPYSSMFILSTTNPLRRLCHY | ||||||
Transmembrane | 1191-1214 | Helical; Name=S1 of repeat III | ||||
Sequence: ILNLRYFEMCILMVIAMSSIALAA | ||||||
Topological domain | 1215-1231 | Extracellular | ||||
Sequence: EDPVQPNAPRNNVLRYF | ||||||
Transmembrane | 1232-1251 | Helical; Name=S2 of repeat III | ||||
Sequence: DYVFTGVFTFEMVIKMIDLG | ||||||
Topological domain | 1252-1258 | Cytoplasmic | ||||
Sequence: LVLHQGA | ||||||
Transmembrane | 1259-1282 | Helical; Name=S3 of repeat III | ||||
Sequence: YFRDLWNILDFIVVSGALVAFAFT | ||||||
Topological domain | 1283-1293 | Extracellular | ||||
Sequence: GNSKGKDINTI | ||||||
Transmembrane | 1294-1311 | Helical; Name=S4 of repeat III | ||||
Sequence: KSLRVLRVLRPLKTIKRL | ||||||
Topological domain | 1312-1330 | Cytoplasmic | ||||
Sequence: PKLKAVFDCVVNSLKNVFN | ||||||
Transmembrane | 1331-1350 | Helical; Name=S5 of repeat III | ||||
Sequence: ILIVYMLFMFIFAVVAVQLF | ||||||
Topological domain | 1351-1437 | Extracellular | ||||
Sequence: KGKFFHCTDESKEFERDCRGKYLLYEKNEVKARDREWKKYDFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRME | ||||||
Transmembrane | 1438-1462 | Helical; Name=S6 of repeat III | ||||
Sequence: MSIFYVVYFVVFPFFFVNIFVALII | ||||||
Topological domain | 1463-1518 | Cytoplasmic | ||||
Sequence: ITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPP | ||||||
Transmembrane | 1519-1537 | Helical; Name=S1 of repeat IV | ||||
Sequence: FEYTIMAMIALNTIVLMMK | ||||||
Topological domain | 1538-1551 | Extracellular | ||||
Sequence: FYGASVAYENALRV | ||||||
Transmembrane | 1552-1573 | Helical; Name=S2 of repeat IV | ||||
Sequence: FNIVFTSLFSLECVLKVMAFGI | ||||||
Topological domain | 1574-1580 | Cytoplasmic | ||||
Sequence: LNYFRDA | ||||||
Transmembrane | 1581-1600 | Helical; Name=S3 of repeat IV | ||||
Sequence: WNIFDFVTVLGSITDILVTE | ||||||
Topological domain | 1601-1607 | Extracellular | ||||
Sequence: FGNNFIN | ||||||
Transmembrane | 1608-1626 | Helical; Name=S4 of repeat IV | ||||
Sequence: LSFLRLFRAARLIKLLRQG | ||||||
Topological domain | 1627-1645 | Cytoplasmic | ||||
Sequence: YTIRILLWTFVQSFKALPY | ||||||
Transmembrane | 1646-1665 | Helical; Name=S5 of repeat IV | ||||
Sequence: VCLLIAMLFFIYAIIGMQVF | ||||||
Topological domain | 1666-1737 | Extracellular | ||||
Sequence: GNIGIDGEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGIQKPECGNEF | ||||||
Transmembrane | 1738-1763 | Helical; Name=S6 of repeat IV | ||||
Sequence: AYFYFVSFIFLCSFLMLNLFVAVIMD | ||||||
Topological domain | 1764-2212 | Cytoplasmic | ||||
Sequence: NFEYLTRDSSILGPHHLDEYVRVWAEYDPAACGRIHYKDMYSLLRVISPPLGLGKKCPHRVACKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAMREEQNRTPLMFQRMEPPSPTQEGGPSQNALPSTQLDPGGGLMAQESSMKESPSWVTQRAQEMFQKTGTWSPERGPPIDMPNSQPNSQSVEMREMGTDGYSDSEHYLPMEGQTRAASMPRLPAENQRRRGRPRGNNLSTISDTSPMKRSASVLGPKARRLDDYSLERVPPEENQRYHQRRRDRGHRTSERSLGRYTDVDTGLGTDLSMTTQSGDLPSKDRDQDRGRPKDRKHRPHHHHHHHHHHPPAPDRERYAQERPDTGRARAREQRWSRSPSEGREHATHRQ |
Keywords
- Cellular component
Phenotypes & Variants
Chemistry
PTM/Processing
Features
Showing features for chain, glycosylation, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000053919 | 1-2212 | Voltage-dependent P/Q-type calcium channel subunit alpha-1A | |||
Sequence: MARFGDEMPGRYGAGGGGSGPAAGVVVGAAGGRGAGGSRQGGQPGAQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIVALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDVEQRHPFDGALRRATLKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLWLAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDEIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQKLALQKAKEVAEVSPLSAANMSIAVKEQQKNQKPAKSVWEQRTSEMRKQNLLASREALYGDAAERWPTTYARPLRPDVKTHLDRPLVVDPQENRNNNTNKSRAPEALRQTARPRESARDPDARRAWPSSPERAPGREGPYGRESEPQQREHAPPREHVPWDADPERAKAGDAPRRHTHRPVAEGEPRRHRARRRPGDEPDDRPERRPRPRDATRPARAADGEGDDGERKRRHRHGPPAHDDRERRHRRRKESQGSGVPMSGPNLSTTRPIQQDLGRQDLPLAEDLDNMKNNKLATGEPASPHDSLGHSGLPPSPAKIGNSTNPGPALATNPQNAASRRTPNNPGNPSNPGPPKTPENSLIVTNPSSTQPNSAKTARKPEHMAVEIPPACPPLNHTVVQVNKNANPDPLPKKEEEKKEEEEADPGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFERDCRGKYLLYEKNEVKARDREWKKYDFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDGEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGIQKPECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAACGRIHYKDMYSLLRVISPPLGLGKKCPHRVACKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAMREEQNRTPLMFQRMEPPSPTQEGGPSQNALPSTQLDPGGGLMAQESSMKESPSWVTQRAQEMFQKTGTWSPERGPPIDMPNSQPNSQSVEMREMGTDGYSDSEHYLPMEGQTRAASMPRLPAENQRRRGRPRGNNLSTISDTSPMKRSASVLGPKARRLDDYSLERVPPEENQRYHQRRRDRGHRTSERSLGRYTDVDTGLGTDLSMTTQSGDLPSKDRDQDRGRPKDRKHRPHHHHHHHHHHPPAPDRERYAQERPDTGRARAREQRWSRSPSEGREHATHRQ | ||||||
Glycosylation | 285 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Modified residue | 411 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 450 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 453 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 752 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 755 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 792 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 1038 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 1042 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 1051 | Phosphoserine | ||||
Sequence: S | ||||||
Glycosylation | 1607 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Modified residue | 1935 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 1998 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 2016 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 2028 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 2030 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 2071 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 2091 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Brain specific. Purkinje cells contain predominantly P-type VSCC, the Q-type being a prominent calcium current in cerebellar granule cells. Also found in heart, in kidney distal convoluted tubule (DCT), and in pituitary.
Interaction
Subunit
Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity (By similarity).
Interacts (via C-terminal CDB motif) with CABP1 in the pre- and postsynaptic membranes (PubMed:11865310).
Interacts with the spider omega-agatoxin-IVA (AC P30288) (PubMed:1311418).
Interacts with TSPOAP1 (By similarity).
Interacts (via C-terminal CDB motif) with CABP1 in the pre- and postsynaptic membranes (PubMed:11865310).
Interacts with the spider omega-agatoxin-IVA (AC P30288) (PubMed:1311418).
Interacts with TSPOAP1 (By similarity).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P54282 | Camk2a P11275 | 3 | EBI-3507416, EBI-2640645 | |
BINARY | P54282 | Rims1 Q9JIR4 | 4 | EBI-3507416, EBI-3507436 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for repeat, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 87-365 | I | ||||
Sequence: NVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIVALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF | ||||||
Region | 385-402 | Binding to the beta subunit | ||||
Sequence: QQIERELNGYMEWISKAE | ||||||
Repeat | 475-719 | II | ||||
Sequence: ERRMRFYIRRMVKTQAFYWTVLSLVALNTLWLAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDEIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNL | ||||||
Region | 814-1117 | Disordered | ||||
Sequence: PDVKTHLDRPLVVDPQENRNNNTNKSRAPEALRQTARPRESARDPDARRAWPSSPERAPGREGPYGRESEPQQREHAPPREHVPWDADPERAKAGDAPRRHTHRPVAEGEPRRHRARRRPGDEPDDRPERRPRPRDATRPARAADGEGDDGERKRRHRHGPPAHDDRERRHRRRKESQGSGVPMSGPNLSTTRPIQQDLGRQDLPLAEDLDNMKNNKLATGEPASPHDSLGHSGLPPSPAKIGNSTNPGPALATNPQNAASRRTPNNPGNPSNPGPPKTPENSLIVTNPSSTQPNSAKTARKPE | ||||||
Compositional bias | 828-843 | Polar residues | ||||
Sequence: PQENRNNNTNKSRAPE | ||||||
Compositional bias | 845-864 | Basic and acidic residues | ||||
Sequence: LRQTARPRESARDPDARRAW | ||||||
Compositional bias | 874-991 | Basic and acidic residues | ||||
Sequence: REGPYGRESEPQQREHAPPREHVPWDADPERAKAGDAPRRHTHRPVAEGEPRRHRARRRPGDEPDDRPERRPRPRDATRPARAADGEGDDGERKRRHRHGPPAHDDRERRHRRRKESQ | ||||||
Compositional bias | 994-1011 | Polar residues | ||||
Sequence: GVPMSGPNLSTTRPIQQD | ||||||
Compositional bias | 1052-1081 | Polar residues | ||||
Sequence: PAKIGNSTNPGPALATNPQNAASRRTPNNP | ||||||
Compositional bias | 1092-1112 | Polar residues | ||||
Sequence: TPENSLIVTNPSSTQPNSAKT | ||||||
Region | 1137-1170 | Disordered | ||||
Sequence: VNKNANPDPLPKKEEEKKEEEEADPGEDGPKPMP | ||||||
Compositional bias | 1144-1164 | Basic and acidic residues | ||||
Sequence: DPLPKKEEEKKEEEEADPGED | ||||||
Repeat | 1182-1465 | III | ||||
Sequence: NPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFERDCRGKYLLYEKNEVKARDREWKKYDFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITF | ||||||
Repeat | 1502-1765 | IV | ||||
Sequence: NKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDGEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGIQKPECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF | ||||||
Region | 1940-2212 | Disordered | ||||
Sequence: QRMEPPSPTQEGGPSQNALPSTQLDPGGGLMAQESSMKESPSWVTQRAQEMFQKTGTWSPERGPPIDMPNSQPNSQSVEMREMGTDGYSDSEHYLPMEGQTRAASMPRLPAENQRRRGRPRGNNLSTISDTSPMKRSASVLGPKARRLDDYSLERVPPEENQRYHQRRRDRGHRTSERSLGRYTDVDTGLGTDLSMTTQSGDLPSKDRDQDRGRPKDRKHRPHHHHHHHHHHPPAPDRERYAQERPDTGRARAREQRWSRSPSEGREHATHRQ | ||||||
Compositional bias | 1947-1962 | Polar residues | ||||
Sequence: PTQEGGPSQNALPSTQ | ||||||
Compositional bias | 1974-1995 | Polar residues | ||||
Sequence: SSMKESPSWVTQRAQEMFQKTG | ||||||
Compositional bias | 2007-2021 | Polar residues | ||||
Sequence: MPNSQPNSQSVEMRE | ||||||
Compositional bias | 2059-2075 | Polar residues | ||||
Sequence: PRGNNLSTISDTSPMKR | ||||||
Compositional bias | 2086-2105 | Basic and acidic residues | ||||
Sequence: RLDDYSLERVPPEENQRYHQ | ||||||
Compositional bias | 2156-2173 | Basic residues | ||||
Sequence: DRKHRPHHHHHHHHHHPP | ||||||
Compositional bias | 2174-2212 | Basic and acidic residues | ||||
Sequence: APDRERYAQERPDTGRARAREQRWSRSPSEGREHATHRQ |
Domain
Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.
Sequence similarities
Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1A subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 4 isoforms produced by Alternative splicing. Additional isoforms seem to exist.
P54282-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length2,212
- Mass (Da)251,527
- Last updated1996-10-01 v1
- ChecksumDFBD7A0F553AFA52
P54282-2
- Name2
- SynonymsRKC8
- Differences from canonical
- 1602-1602: G → GNP
P54282-3
- Name3
- SynonymsRBA-65
P54282-4
- Name4
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8I6B516 | A0A8I6B516_RAT | Cacna1a | 2425 | ||
A0A0G2JXK1 | A0A0G2JXK1_RAT | Cacna1a | 2352 | ||
A0A8I5Y6Y2 | A0A8I5Y6Y2_RAT | Cacna1a | 776 | ||
A0A8I5ZPG4 | A0A8I5ZPG4_RAT | Cacna1a | 2444 |
Features
Showing features for compositional bias, alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 828-843 | Polar residues | ||||
Sequence: PQENRNNNTNKSRAPE | ||||||
Compositional bias | 845-864 | Basic and acidic residues | ||||
Sequence: LRQTARPRESARDPDARRAW | ||||||
Compositional bias | 874-991 | Basic and acidic residues | ||||
Sequence: REGPYGRESEPQQREHAPPREHVPWDADPERAKAGDAPRRHTHRPVAEGEPRRHRARRRPGDEPDDRPERRPRPRDATRPARAADGEGDDGERKRRHRHGPPAHDDRERRHRRRKESQ | ||||||
Compositional bias | 994-1011 | Polar residues | ||||
Sequence: GVPMSGPNLSTTRPIQQD | ||||||
Compositional bias | 1052-1081 | Polar residues | ||||
Sequence: PAKIGNSTNPGPALATNPQNAASRRTPNNP | ||||||
Compositional bias | 1092-1112 | Polar residues | ||||
Sequence: TPENSLIVTNPSSTQPNSAKT | ||||||
Compositional bias | 1144-1164 | Basic and acidic residues | ||||
Sequence: DPLPKKEEEKKEEEEADPGED | ||||||
Alternative sequence | VSP_000881 | 1602 | in isoform 2 | |||
Sequence: G → GNP | ||||||
Compositional bias | 1947-1962 | Polar residues | ||||
Sequence: PTQEGGPSQNALPSTQ | ||||||
Compositional bias | 1974-1995 | Polar residues | ||||
Sequence: SSMKESPSWVTQRAQEMFQKTG | ||||||
Compositional bias | 2007-2021 | Polar residues | ||||
Sequence: MPNSQPNSQSVEMRE | ||||||
Compositional bias | 2059-2075 | Polar residues | ||||
Sequence: PRGNNLSTISDTSPMKR | ||||||
Compositional bias | 2086-2105 | Basic and acidic residues | ||||
Sequence: RLDDYSLERVPPEENQRYHQ | ||||||
Compositional bias | 2156-2173 | Basic residues | ||||
Sequence: DRKHRPHHHHHHHHHHPP | ||||||
Compositional bias | 2174-2212 | Basic and acidic residues | ||||
Sequence: APDRERYAQERPDTGRARAREQRWSRSPSEGREHATHRQ |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
M64373 EMBL· GenBank· DDBJ | AAA40806.1 EMBL· GenBank· DDBJ | mRNA | ||
M99222 EMBL· GenBank· DDBJ | AAA40896.1 EMBL· GenBank· DDBJ | mRNA |