P54269 · CAUP_DROME
- ProteinHomeobox protein caupolican
- Genecaup
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids693 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Controls proneural and vein forming genes. Positive transcriptional controller of ac-sc (achaete-scute). May act as an activator that interacts with the transcriptional complex assembled on the ac and sc promoters and participates in transcription initiation.
Miscellaneous
'Caupolican' is named after the Araucanian American-Indian tribe, also called mohawks, who shaved all but a medial stripe of hairs on the head.
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 226-288 | Homeobox; TALE-type | ||||
Sequence: LAARRKNATRESTATLKAWLSEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKEN |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | DNA-binding transcription factor activity | |
Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
Biological Process | cell development | |
Biological Process | compound eye morphogenesis | |
Biological Process | equator specification | |
Biological Process | imaginal disc-derived wing vein specification | |
Biological Process | muscle cell fate commitment | |
Biological Process | negative regulation of growth | |
Biological Process | neuron differentiation | |
Biological Process | positive regulation of transcription by RNA polymerase II | |
Biological Process | regulation of mitotic cell cycle | |
Biological Process | regulation of transcription by RNA polymerase II |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHomeobox protein caupolican
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionP54269
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000048845 | 1-693 | Homeobox protein caupolican | |||
Sequence: MAAYAQFGYAGYPTANQLTTANTDSQSGHGGGSPLSGTNEASLSPSGGSTATGLTAGPLSPGAVSQSSHHAGHKGLSTSPAEDVVGGDVPVGLSSAAQDLPSRGSCCENGRPIITDPVSGQTVCSCQYDPARLAIGGYSRMALPSGGVGVGVYGGPYPSNEQNPYPSIGVDNSAFYAPLSNPYGIKDTSPSTEMSAWTSASLQSTTGYYSYDPTLAAYGYGPNYDLAARRKNATRESTATLKAWLSEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWEPKNKTEDDDDGMMSDDEKEKDAGDGGKLSTEAFDPGNQLIKSELGKAEKEVDSSGDQKLDLDREPHNLVAMRGLAPYATPPGAHPMHAAYSSYAQSHNTHTHPHPQQMQHHQQQQQQQQNQQQLQHHQMDQPYYHPGGYGQEESGEFAAQKNPLSRDCGIPVPASKPKIWSVADTAACKTPPPTAAYLGQNFYPPSSADQQLPHQPLQQHQQQQLQQLQQQQQHHHHPHHHHPHHSMELGSPLSMMSSYAGGSPYSRIPTAYTEAMGMHLPSSSSSSSSTGKLPPTHIHPAPQRVGFPEIQPDTPPQTPPTMKLNSSGGSSSSSGSSHSSSMHSVTPVTVASMVNILYSNTDSGYGHGHSHGHGHGHGHGLGHGHGLGHGHGHMGVTSNAYLTEGGRSGS |
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 20-74 | Polar residues | ||||
Sequence: TANTDSQSGHGGGSPLSGTNEASLSPSGGSTATGLTAGPLSPGAVSQSSHHAGHK | ||||||
Region | 20-104 | Disordered | ||||
Sequence: TANTDSQSGHGGGSPLSGTNEASLSPSGGSTATGLTAGPLSPGAVSQSSHHAGHKGLSTSPAEDVVGGDVPVGLSSAAQDLPSRG | ||||||
Compositional bias | 288-302 | Basic and acidic residues | ||||
Sequence: NKMTWEPKNKTEDDD | ||||||
Region | 288-331 | Disordered | ||||
Sequence: NKMTWEPKNKTEDDDDGMMSDDEKEKDAGDGGKLSTEAFDPGNQ | ||||||
Compositional bias | 387-422 | Polar residues | ||||
Sequence: AQSHNTHTHPHPQQMQHHQQQQQQQQNQQQLQHHQM | ||||||
Region | 387-453 | Disordered | ||||
Sequence: AQSHNTHTHPHPQQMQHHQQQQQQQQNQQQLQHHQMDQPYYHPGGYGQEESGEFAAQKNPLSRDCGI | ||||||
Region | 480-538 | Disordered | ||||
Sequence: YLGQNFYPPSSADQQLPHQPLQQHQQQQLQQLQQQQQHHHHPHHHHPHHSMELGSPLSM | ||||||
Compositional bias | 483-515 | Polar residues | ||||
Sequence: QNFYPPSSADQQLPHQPLQQHQQQQLQQLQQQQ | ||||||
Compositional bias | 561-577 | Polar residues | ||||
Sequence: MHLPSSSSSSSSTGKLP | ||||||
Region | 561-627 | Disordered | ||||
Sequence: MHLPSSSSSSSSTGKLPPTHIHPAPQRVGFPEIQPDTPPQTPPTMKLNSSGGSSSSSGSSHSSSMHS | ||||||
Compositional bias | 603-627 | Polar residues | ||||
Sequence: PTMKLNSSGGSSSSSGSSHSSSMHS | ||||||
Region | 648-693 | Disordered | ||||
Sequence: YGHGHSHGHGHGHGHGLGHGHGLGHGHGHMGVTSNAYLTEGGRSGS | ||||||
Compositional bias | 653-669 | Basic residues | ||||
Sequence: SHGHGHGHGHGLGHGHG |
Sequence similarities
Belongs to the TALE/IRO homeobox family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length693
- Mass (Da)73,668
- Last updated2001-08-14 v2
- ChecksumFBEB1616493F7EC9
Features
Showing features for compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 20-74 | Polar residues | ||||
Sequence: TANTDSQSGHGGGSPLSGTNEASLSPSGGSTATGLTAGPLSPGAVSQSSHHAGHK | ||||||
Sequence conflict | 106 | in Ref. 1; CAA64485 | ||||
Sequence: C → R | ||||||
Compositional bias | 288-302 | Basic and acidic residues | ||||
Sequence: NKMTWEPKNKTEDDD | ||||||
Sequence conflict | 316 | in Ref. 1; CAA64485 | ||||
Sequence: G → A | ||||||
Compositional bias | 387-422 | Polar residues | ||||
Sequence: AQSHNTHTHPHPQQMQHHQQQQQQQQNQQQLQHHQM | ||||||
Compositional bias | 483-515 | Polar residues | ||||
Sequence: QNFYPPSSADQQLPHQPLQQHQQQQLQQLQQQQ | ||||||
Sequence conflict | 518 | in Ref. 4; AAV36871 | ||||
Sequence: H → N | ||||||
Compositional bias | 561-577 | Polar residues | ||||
Sequence: MHLPSSSSSSSSTGKLP | ||||||
Compositional bias | 603-627 | Polar residues | ||||
Sequence: PTMKLNSSGGSSSSSGSSHSSSMHS | ||||||
Compositional bias | 653-669 | Basic residues | ||||
Sequence: SHGHGHGHGHGLGHGHG | ||||||
Sequence conflict | 678 | in Ref. 1; CAA64485 | ||||
Sequence: G → A |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X95178 EMBL· GenBank· DDBJ | CAA64485.1 EMBL· GenBank· DDBJ | mRNA | ||
AE014296 EMBL· GenBank· DDBJ | AAF49895.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BT015986 EMBL· GenBank· DDBJ | AAV36871.1 EMBL· GenBank· DDBJ | mRNA | ||
BT021246 EMBL· GenBank· DDBJ | AAX33394.1 EMBL· GenBank· DDBJ | mRNA | ||
AY122206 EMBL· GenBank· DDBJ | AAM52718.1 EMBL· GenBank· DDBJ | mRNA |