P54201 · UBPA_DICDI

Function

function

Required for development but not growth.

Catalytic activity

  • Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
    EC:3.4.19.12 (UniProtKB | ENZYME | Rhea)

Features

Showing features for active site.

1837100200300400500600700800
TypeIDPosition(s)Description
Active site328Nucleophile
Active site797Proton acceptor

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular Componentnucleus
Molecular Functioncysteine-type deubiquitinase activity
Molecular Functionzinc ion binding
Biological Processoscillatory cAMP signaling
Biological Processpositive regulation of gene expression
Biological Processprotein deubiquitination
Biological Processproteolysis
Biological Processsorocarp development

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Ubiquitin carboxyl-terminal hydrolase A
  • EC number
  • Alternative names
    • Deubiquitinating enzyme A
    • Ubiquitin thioesterase A
    • Ubiquitin-specific-processing protease A

Gene names

    • Name
      ubpA
    • Synonyms
      usp5
    • ORF names
      DDB_G0291239

Organism names

Accessions

  • Primary accession
    P54201
  • Secondary accessions
    • Q54EP2

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000806861-837Ubiquitin carboxyl-terminal hydrolase A

Proteomic databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for zinc finger, domain, region, compositional bias.

TypeIDPosition(s)Description
Zinc finger166-277UBP-type; degenerate
Domain319-835USP
Domain628-669UBA 1
Region676-695Disordered
Compositional bias677-695Polar residues
Domain700-740UBA 2

Sequence similarities

Belongs to the peptidase C19 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    837
  • Mass (Da)
    94,966
  • Last updated
    2007-12-04 v2
  • Checksum
    5E50A4E2CFE68BB4
MELFPELKNIKVPTEKSRLWKDECCYCFDTPENGEGLFIDLIGLLAFSKKYVQLNHQKTHHHLYLNFKKVAIVNEKVKSPTIENGGEEKPPKKLAIGVEGGFNVEDEEIKYEEHYKLYIFPDDKFLELSDPIIPENVRVCCEKIKTLNSQSRKEEIVSWNAESVFPSAFAESIIQLDNNTKKIDPKGPWRCDIEGCDKVENLWLNLTDGFIGCGRKYADGTGGNGHAQEHFNQTQYPISVKLGTITKDHADVYSYPEDDMVSDPLLFQHLTHWGLNPNVMVKTEKSMAELELDQNLNFEFGKIQEKGKLLENVFGPGLTGIENLGNSCYMSSVIQMIFAIDSFQTRYLKDREASFKDITQDPTQSFEIQMSKLAHGLLSGDYSIPLSKPSKNANEESEAATQIGIAPKMFKSLIGASHAEFSTMKQQDAHEYLQYLLEYIERAEHSRPSWIQQANPTRLFQFHNEDRIECGSSGQVKYTRRLENILSVPVNLDDATNKQEVAQYEETLKQQNGVRQKDQEEIRPIIPLVSCINGFVEPYRVEDFLSPATGVKTFSLNSSRMATFPEVLIIHLKKYTYNADYTPKKLNVFMDVPDIIDIDSLRGRGIKEGEVPLKEGTINTTTKVPEPSFNQEVLDTLLSMDFPLVRCKKALLATGGKDAELAMNWIFEHTEDPDIDIEQTPVNNNNNNNNSSNSNDKLFVFNSQDVDNIIGMGFTDSQAKLALKNTKGNLERAADWLFSHIDNLDELVAKDNASTSSINPSLIPQSTTSLQPVSDGVGKYELLGFISHLGNNVTCGHYVCHIKKNNRWIKFNDRHVQLSEQPPKELGYIYFYKRQLN

Sequence caution

The sequence EAL61603.2 differs from that shown. Reason: Erroneous gene model prediction

Features

Showing features for sequence conflict, compositional bias.

TypeIDPosition(s)Description
Sequence conflict180in Ref. 1; AAC71068
Compositional bias677-695Polar residues
Sequence conflict683in Ref. 1; AAC71068

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U48271
EMBL· GenBank· DDBJ
AAC71068.1
EMBL· GenBank· DDBJ
mRNA
AAFI02000177
EMBL· GenBank· DDBJ
EAL61603.2
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.

Genome annotation databases

Similar Proteins

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