P54201 · UBPA_DICDI
- ProteinUbiquitin carboxyl-terminal hydrolase A
- GeneubpA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids837 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Required for development but not growth.
Catalytic activity
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 328 | Nucleophile | ||||
Sequence: C | ||||||
Active site | 797 | Proton acceptor | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | cytosol | |
Cellular Component | nucleus | |
Molecular Function | cysteine-type deubiquitinase activity | |
Molecular Function | zinc ion binding | |
Biological Process | oscillatory cAMP signaling | |
Biological Process | positive regulation of gene expression | |
Biological Process | protein deubiquitination | |
Biological Process | proteolysis | |
Biological Process | sorocarp development |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameUbiquitin carboxyl-terminal hydrolase A
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Amoebozoa > Evosea > Eumycetozoa > Dictyostelia > Dictyosteliales > Dictyosteliaceae > Dictyostelium
Accessions
- Primary accessionP54201
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000080686 | 1-837 | Ubiquitin carboxyl-terminal hydrolase A | |||
Sequence: MELFPELKNIKVPTEKSRLWKDECCYCFDTPENGEGLFIDLIGLLAFSKKYVQLNHQKTHHHLYLNFKKVAIVNEKVKSPTIENGGEEKPPKKLAIGVEGGFNVEDEEIKYEEHYKLYIFPDDKFLELSDPIIPENVRVCCEKIKTLNSQSRKEEIVSWNAESVFPSAFAESIIQLDNNTKKIDPKGPWRCDIEGCDKVENLWLNLTDGFIGCGRKYADGTGGNGHAQEHFNQTQYPISVKLGTITKDHADVYSYPEDDMVSDPLLFQHLTHWGLNPNVMVKTEKSMAELELDQNLNFEFGKIQEKGKLLENVFGPGLTGIENLGNSCYMSSVIQMIFAIDSFQTRYLKDREASFKDITQDPTQSFEIQMSKLAHGLLSGDYSIPLSKPSKNANEESEAATQIGIAPKMFKSLIGASHAEFSTMKQQDAHEYLQYLLEYIERAEHSRPSWIQQANPTRLFQFHNEDRIECGSSGQVKYTRRLENILSVPVNLDDATNKQEVAQYEETLKQQNGVRQKDQEEIRPIIPLVSCINGFVEPYRVEDFLSPATGVKTFSLNSSRMATFPEVLIIHLKKYTYNADYTPKKLNVFMDVPDIIDIDSLRGRGIKEGEVPLKEGTINTTTKVPEPSFNQEVLDTLLSMDFPLVRCKKALLATGGKDAELAMNWIFEHTEDPDIDIEQTPVNNNNNNNNSSNSNDKLFVFNSQDVDNIIGMGFTDSQAKLALKNTKGNLERAADWLFSHIDNLDELVAKDNASTSSINPSLIPQSTTSLQPVSDGVGKYELLGFISHLGNNVTCGHYVCHIKKNNRWIKFNDRHVQLSEQPPKELGYIYFYKRQLN |
Proteomic databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for zinc finger, domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Zinc finger | 166-277 | UBP-type; degenerate | ||||
Sequence: PSAFAESIIQLDNNTKKIDPKGPWRCDIEGCDKVENLWLNLTDGFIGCGRKYADGTGGNGHAQEHFNQTQYPISVKLGTITKDHADVYSYPEDDMVSDPLLFQHLTHWGLNP | ||||||
Domain | 319-835 | USP | ||||
Sequence: TGIENLGNSCYMSSVIQMIFAIDSFQTRYLKDREASFKDITQDPTQSFEIQMSKLAHGLLSGDYSIPLSKPSKNANEESEAATQIGIAPKMFKSLIGASHAEFSTMKQQDAHEYLQYLLEYIERAEHSRPSWIQQANPTRLFQFHNEDRIECGSSGQVKYTRRLENILSVPVNLDDATNKQEVAQYEETLKQQNGVRQKDQEEIRPIIPLVSCINGFVEPYRVEDFLSPATGVKTFSLNSSRMATFPEVLIIHLKKYTYNADYTPKKLNVFMDVPDIIDIDSLRGRGIKEGEVPLKEGTINTTTKVPEPSFNQEVLDTLLSMDFPLVRCKKALLATGGKDAELAMNWIFEHTEDPDIDIEQTPVNNNNNNNNSSNSNDKLFVFNSQDVDNIIGMGFTDSQAKLALKNTKGNLERAADWLFSHIDNLDELVAKDNASTSSINPSLIPQSTTSLQPVSDGVGKYELLGFISHLGNNVTCGHYVCHIKKNNRWIKFNDRHVQLSEQPPKELGYIYFYKRQ | ||||||
Domain | 628-669 | UBA 1 | ||||
Sequence: SFNQEVLDTLLSMDFPLVRCKKALLATGGKDAELAMNWIFEH | ||||||
Region | 676-695 | Disordered | ||||
Sequence: DIEQTPVNNNNNNNNSSNSN | ||||||
Compositional bias | 677-695 | Polar residues | ||||
Sequence: IEQTPVNNNNNNNNSSNSN | ||||||
Domain | 700-740 | UBA 2 | ||||
Sequence: VFNSQDVDNIIGMGFTDSQAKLALKNTKGNLERAADWLFSH |
Sequence similarities
Belongs to the peptidase C19 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length837
- Mass (Da)94,966
- Last updated2007-12-04 v2
- Checksum5E50A4E2CFE68BB4
Sequence caution
Features
Showing features for sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 180 | in Ref. 1; AAC71068 | ||||
Sequence: T → N | ||||||
Compositional bias | 677-695 | Polar residues | ||||
Sequence: IEQTPVNNNNNNNNSSNSN | ||||||
Sequence conflict | 683 | in Ref. 1; AAC71068 | ||||
Sequence: N → I |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U48271 EMBL· GenBank· DDBJ | AAC71068.1 EMBL· GenBank· DDBJ | mRNA | ||
AAFI02000177 EMBL· GenBank· DDBJ | EAL61603.2 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. |