Fir1 is an intrinsically disordered protein localized to the cytokinesis site that is degraded upon septum completion but stabilized when septation is aberrant. Fir1 protects cytokinesis in part by inhibiting a separation-specific exocytosis function of the Cbk1 a key component of "hippo" signaling that induces mother-daughter separation.
Cbk1 and Bck2 are required for Mpk1 activation during heat shock and cell wall stress and for Mpk1 dephosphorylation during heat shock adaptation., Genetic Interactions|Strains/Constructs|Regulatory Role|Mutants/Phenotypes|Primary Literature|Function/Process
CBK1-S745F allele leads to a constitutively active form of Cbk1p that is independent of the upstream RAM network., Protein Processing/Modification/Regulation|Genetic Interactions|Strains/Constructs|Cellular Location|Mutants/Phenotypes|Protein Sequence Features|Primary Literature
Cbk1 regulation of the RNA-binding protein Ssd1 integrates cell fate with translational control., Genetic Interactions|Strains/Constructs|Regulatory Role|Mutants/Phenotypes|Substrates/Ligands/Cofactors|Primary Literature
Mutations in BRR1 or MPT5 lead to a restoration of fertility induced by cbk1p mutation and a more-or-less pronounced restoration of polarity; they also show genetic interactions with SSD1., Genetic Interactions|Strains/Constructs|Cellular Location|Mutants/Phenotypes|Primary Literature
Strains/Constructs|Regulation of|Protein-protein Interactions|Mutants/Phenotypes|Non-Fungal Related Genes/Proteins|Primary Literature|Function/Process|Disease Gene Related
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