P53789 · VTDB_RABIT
- ProteinVitamin D-binding protein
- GeneGC
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids476 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | blood microparticle | |
Cellular Component | cytoplasm | |
Molecular Function | actin binding | |
Molecular Function | vitamin D binding | |
Molecular Function | vitamin transmembrane transporter activity |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameVitamin D-binding protein
- Short namesDBP; VDB
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Lagomorpha > Leporidae > Oryctolagus
Accessions
- Primary accessionP53789
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, disulfide bond, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-16 | |||||
Sequence: MKRVLLLLLAVVCGHA | ||||||
Chain | PRO_0000001104 | 17-476 | Vitamin D-binding protein | |||
Sequence: LERGRDYEKDKVCKELSTLGKDDFRTLSLVLYSRKFPSGTFDQVMKLVKEVVSLTEDCCTEDADPGCYDNRTSALSATSCESDSPFPVHPGTAECCTKEGLGRKLCMAALKHPPQEFPTYVEPANDEICEAFRQDPMEFADKFLYEYSSNYGQAPLPILVSYTKSYLSMVGTCCTSASPTVCFLKERLQIKHLSLLTTLSNRVCSQYAAYGKEKSRRSHLIKLAQKAPTAALKEVLPLAEDITNILSKCCESTSEDCMAKELPEHTVKICDTLSTKNPKFEECCQEKTPMDIFVCTYFMPAAQPPEPANVELPTSKDVCDSKNINVMDQYTFELSRKTHIPEVFLSKVLEPTLKSLSECCHSADSTACLNAKGPVLKKEVSSFIDKGQELCAGYSENTFTEYKKKLSQQLRAKLPEATSAELAELVEKHSDFASKCCSINSPPNYCDSEIDAEIKNLPEP | ||||||
Disulfide bond | 29↔75 | |||||
Sequence: CKELSTLGKDDFRTLSLVLYSRKFPSGTFDQVMKLVKEVVSLTEDCC | ||||||
Disulfide bond | 74↔83 | |||||
Sequence: CCTEDADPGC | ||||||
Glycosylation | 86 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 96↔112 | |||||
Sequence: CESDSPFPVHPGTAECC | ||||||
Disulfide bond | 111↔122 | |||||
Sequence: CCTKEGLGRKLC | ||||||
Disulfide bond | 145↔190 | |||||
Sequence: CEAFRQDPMEFADKFLYEYSSNYGQAPLPILVSYTKSYLSMVGTCC | ||||||
Disulfide bond | 189↔198 | |||||
Sequence: CCTSASPTVC | ||||||
Disulfide bond | 220↔266 | |||||
Sequence: CSQYAAYGKEKSRRSHLIKLAQKAPTAALKEVLPLAEDITNILSKCC | ||||||
Disulfide bond | 265↔273 | |||||
Sequence: CCESTSEDC | ||||||
Disulfide bond | 286↔300 | |||||
Sequence: CDTLSTKNPKFEECC | ||||||
Disulfide bond | 299↔311 | |||||
Sequence: CCQEKTPMDIFVC | ||||||
Disulfide bond | 335↔376 | |||||
Sequence: CDSKNINVMDQYTFELSRKTHIPEVFLSKVLEPTLKSLSECC | ||||||
Disulfide bond | 375↔384 | |||||
Sequence: CCHSADSTAC | ||||||
Disulfide bond | 407↔453 | |||||
Sequence: CAGYSENTFTEYKKKLSQQLRAKLPEATSAELAELVEKHSDFASKCC | ||||||
Disulfide bond | 452↔462 | |||||
Sequence: CCSINSPPNYC |
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Subunit
Associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes. Interacts with LRP2; the interaction is required for renal uptake of GC in complex with 25-hydroxyvitamin D3.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 17-208 | Albumin 1 | ||||
Sequence: LERGRDYEKDKVCKELSTLGKDDFRTLSLVLYSRKFPSGTFDQVMKLVKEVVSLTEDCCTEDADPGCYDNRTSALSATSCESDSPFPVHPGTAECCTKEGLGRKLCMAALKHPPQEFPTYVEPANDEICEAFRQDPMEFADKFLYEYSSNYGQAPLPILVSYTKSYLSMVGTCCTSASPTVCFLKERLQIKH | ||||||
Domain | 209-394 | Albumin 2 | ||||
Sequence: LSLLTTLSNRVCSQYAAYGKEKSRRSHLIKLAQKAPTAALKEVLPLAEDITNILSKCCESTSEDCMAKELPEHTVKICDTLSTKNPKFEECCQEKTPMDIFVCTYFMPAAQPPEPANVELPTSKDVCDSKNINVMDQYTFELSRKTHIPEVFLSKVLEPTLKSLSECCHSADSTACLNAKGPVLKK | ||||||
Domain | 395-476 | Albumin 3 | ||||
Sequence: EVSSFIDKGQELCAGYSENTFTEYKKKLSQQLRAKLPEATSAELAELVEKHSDFASKCCSINSPPNYCDSEIDAEIKNLPEP |
Sequence similarities
Belongs to the ALB/AFP/VDB family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length476
- Mass (Da)52,912
- Last updated1996-10-01 v1
- Checksum276A530196B014A5
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
D29666 EMBL· GenBank· DDBJ | BAA06137.1 EMBL· GenBank· DDBJ | mRNA |