P53789 · VTDB_RABIT

Function

function

Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentblood microparticle
Cellular Componentcytoplasm
Molecular Functionactin binding
Molecular Functionvitamin D binding
Molecular Functionvitamin transmembrane transporter activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Vitamin D-binding protein
  • Short names
    DBP; VDB
  • Alternative names
    • Gc-globulin
    • Group-specific component

Gene names

    • Name
      GC
    • Synonyms
      DBP

Organism names

  • Taxonomic identifier
  • Strain
    • New Zealand white
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Lagomorpha > Leporidae > Oryctolagus

Accessions

  • Primary accession
    P53789

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation.

TypeIDPosition(s)Description
Signal1-16
ChainPRO_000000110417-476Vitamin D-binding protein
Disulfide bond29↔75
Disulfide bond74↔83
Glycosylation86N-linked (GlcNAc...) asparagine
Disulfide bond96↔112
Disulfide bond111↔122
Disulfide bond145↔190
Disulfide bond189↔198
Disulfide bond220↔266
Disulfide bond265↔273
Disulfide bond286↔300
Disulfide bond299↔311
Disulfide bond335↔376
Disulfide bond375↔384
Disulfide bond407↔453
Disulfide bond452↔462

Keywords

Proteomic databases

PTM databases

Interaction

Subunit

Associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes. Interacts with LRP2; the interaction is required for renal uptake of GC in complex with 25-hydroxyvitamin D3.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain17-208Albumin 1
Domain209-394Albumin 2
Domain395-476Albumin 3

Sequence similarities

Belongs to the ALB/AFP/VDB family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    476
  • Mass (Da)
    52,912
  • Last updated
    1996-10-01 v1
  • Checksum
    276A530196B014A5
MKRVLLLLLAVVCGHALERGRDYEKDKVCKELSTLGKDDFRTLSLVLYSRKFPSGTFDQVMKLVKEVVSLTEDCCTEDADPGCYDNRTSALSATSCESDSPFPVHPGTAECCTKEGLGRKLCMAALKHPPQEFPTYVEPANDEICEAFRQDPMEFADKFLYEYSSNYGQAPLPILVSYTKSYLSMVGTCCTSASPTVCFLKERLQIKHLSLLTTLSNRVCSQYAAYGKEKSRRSHLIKLAQKAPTAALKEVLPLAEDITNILSKCCESTSEDCMAKELPEHTVKICDTLSTKNPKFEECCQEKTPMDIFVCTYFMPAAQPPEPANVELPTSKDVCDSKNINVMDQYTFELSRKTHIPEVFLSKVLEPTLKSLSECCHSADSTACLNAKGPVLKKEVSSFIDKGQELCAGYSENTFTEYKKKLSQQLRAKLPEATSAELAELVEKHSDFASKCCSINSPPNYCDSEIDAEIKNLPEP

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
D29666
EMBL· GenBank· DDBJ
BAA06137.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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