P53555 · BIOK_BACSU

Function

function

Catalyzes the transfer of the alpha-amino group from L-lysine to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). B.subtilis is the only bacterium known to utilize L-lysine as an amino donor in the biosynthesis of DAPA.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Activity regulation

Inhibited by 7-keto-8-aminopelargonic acid at concentrations above 80 uM.

pH Dependence

Optimum pH is 8.6.

Pathway

Cofactor biosynthesis; biotin biosynthesis; 7,8-diaminononanoate from 8-amino-7-oxononanoate (Lys route).

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site113-114pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site146substrate
Binding site251pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site315substrate
Binding site316-317pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site410substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionadenosylmethionine-8-amino-7-oxononanoate transaminase activity
Molecular Functionpyridoxal phosphate binding
Biological Processbiotin biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    L-Lysine--8-amino-7-oxononanoate transaminase
  • EC number
  • Alternative names
    • 7,8-diamino-pelargonic acid aminotransferase
      (DAPA AT; DAPA aminotransferase
      )
    • 7,8-diaminononanoate synthase (DANS)
    • Diaminopelargonic acid synthase
    • L-Lysine--8-amino-7-oxononanoate aminotransferase

Gene names

    • Name
      bioK
    • Synonyms
      bioA
    • Ordered locus names
      BSU30230

Organism names

Accessions

  • Primary accession
    P53555

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00001203611-448L-Lysine--8-amino-7-oxononanoate transaminase
Modified residue280N6-(pyridoxal phosphate)lysine

Proteomic databases

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    448
  • Mass (Da)
    50,112
  • Last updated
    1996-10-01 v1
  • Checksum
    38F104A93A74AA24
MTHDLIEKSKKHLWLPFTQMKDYDENPLIIESGTGIKVKDINGKEYYDGFSSVWLNVHGHRKKELDDAIKKQLGKIAHSTLLGMTNVPATQLAETLIDISPKKLTRVFYSDSGAEAMEIALKMAFQYWKNIGKPEKQKFIAMKNGYHGDTIGAVSVGSIELFHHVYGPLMFESYKAPIPYVYRSESGDPDECRDQCLRELAQLLEEHHEEIAALSIESMVQGASGMIVMPEGYLAGVRELCTTYDVLMIVDEVATGFGRTGKMFACEHENVQPDLMAAGKGITGGYLPIAVTFATEDIYKAFYDDYENLKTFFHGHSYTGNQLGCAVALENLALFESENIVEQVAEKSKKLHFLLQDLHALPHVGDIRQLGFMCGAELVRSKETKEPYPADRRIGYKVSLKMRELGMLTRPLGDVIAFLPPLASTAEELSEMVAIMKQAIHEVTSLED

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U51868
EMBL· GenBank· DDBJ
AAB17458.1
EMBL· GenBank· DDBJ
Genomic DNA
AF008220
EMBL· GenBank· DDBJ
AAC00262.1
EMBL· GenBank· DDBJ
Genomic DNA
AL009126
EMBL· GenBank· DDBJ
CAB15001.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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