P53492 · ACT7_ARATH
- ProteinActin-7
- GeneACT7
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids377 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells (PubMed:11449050).
Essential component of cell cytoskeleton; plays an important role in cytoplasmic streaming, cell shape determination, cell division, organelle movement and extension growth (PubMed:11449050).
This is considered as one of the vegetative actins which is involved in the regulation of hormone-induced plant cell proliferation and callus formation (PubMed:11449050).
Required for the trafficking and endocytic recycling of ABCG36/PEN3 between the trans-Golgi network and the plasma membrane in root epidermal and cap cells (PubMed:27803190).
Essential component of cell cytoskeleton; plays an important role in cytoplasmic streaming, cell shape determination, cell division, organelle movement and extension growth (PubMed:11449050).
This is considered as one of the vegetative actins which is involved in the regulation of hormone-induced plant cell proliferation and callus formation (PubMed:11449050).
Required for the trafficking and endocytic recycling of ABCG36/PEN3 between the trans-Golgi network and the plasma membrane in root epidermal and cap cells (PubMed:27803190).
Miscellaneous
There are 8 actin genes in A.thaliana.
Catalytic activity
- ATP + H2O = ADP + phosphate + H+
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | chloroplast envelope | |
Cellular Component | chloroplast stroma | |
Cellular Component | cytoskeleton | |
Cellular Component | cytosol | |
Cellular Component | mitochondrion | |
Cellular Component | nucleolus | |
Cellular Component | plant-type cell wall | |
Cellular Component | plasma membrane | |
Cellular Component | plasmodesma | |
Molecular Function | ATP binding | |
Molecular Function | hydrolase activity | |
Molecular Function | structural constituent of cytoskeleton | |
Biological Process | cell division | |
Biological Process | Golgi to plasma membrane transport | |
Biological Process | protein localization | |
Biological Process | protein transport | |
Biological Process | response to auxin | |
Biological Process | response to light stimulus | |
Biological Process | response to wounding | |
Biological Process | root development | |
Biological Process | root epidermal cell differentiation | |
Biological Process | root hair elongation | |
Biological Process | seed germination |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameActin-7
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionP53492
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
Impaired trafficking and endocytic recycling of ABCG36/PEN3 between the trans-Golgi network and the plasma membrane in root epidermal and cap cells.
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Mutagenesis | 15 | In act7-9; impaired trafficking and endocytic recycling of ABCG36/PEN3 between the trans-Golgi network and the plasma membrane in root epidermal and cap cells. | |||
Mutagenesis | 108 | In act7-8; impaired trafficking and endocytic recycling of ABCG36/PEN3 between the trans-Golgi network and the plasma membrane in root epidermal and cap cells. | |||
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1 variant from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for initiator methionine, modified residue, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Initiator methionine | 1 | Removed | |||
Modified residue | 2 | N-acetylalanine | |||
Chain | PRO_0000088892 | 2-377 | Actin-7 | ||
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Constitutively expressed at high levels in young expanding vegetative tissues. Also strongly expressed in the hypocotyl and seed coat. Little or no expression is detected in mature pollen sacs, ovules, embryos or seeds.
Induction
Differentially regulated in response to exogenous hormone treatment. In particular, auxin is a strong inducer.
Gene expression databases
Interaction
Subunit
Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. The binding of profilin to monomeric G-actin cause the sequestration of actin into profilactin complexes, and prevents the polymerization.
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length377
- Mass (Da)41,736
- Last updated1996-10-01 v1
- MD5 Checksum2FFCB53B7D2D14D012C2571879D417C1
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U37281 EMBL· GenBank· DDBJ | AAA80356.1 EMBL· GenBank· DDBJ | mRNA | ||
U27811 EMBL· GenBank· DDBJ | AAB52506.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB016893 EMBL· GenBank· DDBJ | BAB09402.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002688 EMBL· GenBank· DDBJ | AED91450.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY062702 EMBL· GenBank· DDBJ | AAL32780.1 EMBL· GenBank· DDBJ | mRNA | ||
AY063980 EMBL· GenBank· DDBJ | AAL36336.1 EMBL· GenBank· DDBJ | mRNA | ||
AY096397 EMBL· GenBank· DDBJ | AAM20037.1 EMBL· GenBank· DDBJ | mRNA | ||
AY114679 EMBL· GenBank· DDBJ | AAM47998.1 EMBL· GenBank· DDBJ | mRNA | ||
AY120779 EMBL· GenBank· DDBJ | AAM53337.1 EMBL· GenBank· DDBJ | mRNA |