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P53492 · ACT7_ARATH

Function

function

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells (PubMed:11449050).
Essential component of cell cytoskeleton; plays an important role in cytoplasmic streaming, cell shape determination, cell division, organelle movement and extension growth (PubMed:11449050).
This is considered as one of the vegetative actins which is involved in the regulation of hormone-induced plant cell proliferation and callus formation (PubMed:11449050).
Required for the trafficking and endocytic recycling of ABCG36/PEN3 between the trans-Golgi network and the plasma membrane in root epidermal and cap cells (PubMed:27803190).

Miscellaneous

There are 8 actin genes in A.thaliana.

Catalytic activity

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchloroplast envelope
Cellular Componentchloroplast stroma
Cellular Componentcytoskeleton
Cellular Componentcytosol
Cellular Componentmitochondrion
Cellular Componentnucleolus
Cellular Componentplant-type cell wall
Cellular Componentplasma membrane
Cellular Componentplasmodesma
Molecular FunctionATP binding
Molecular Functionhydrolase activity
Molecular Functionstructural constituent of cytoskeleton
Biological Processcell division
Biological ProcessGolgi to plasma membrane transport
Biological Processprotein localization
Biological Processprotein transport
Biological Processresponse to auxin
Biological Processresponse to light stimulus
Biological Processresponse to wounding
Biological Processroot development
Biological Processroot epidermal cell differentiation
Biological Processroot hair elongation
Biological Processseed germination

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Actin-7
  • EC number
  • Alternative names
    • Actin-2

Gene names

    • Name
      ACT7
    • ORF names
      MYH9.2
    • Ordered locus names
      At5g09810

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    P53492
  • Secondary accessions
    • P53495

Proteomes

Organism-specific databases

Genome annotation databases

Phenotypes & Variants

Disruption phenotype

Impaired trafficking and endocytic recycling of ABCG36/PEN3 between the trans-Golgi network and the plasma membrane in root epidermal and cap cells.

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis15In act7-9; impaired trafficking and endocytic recycling of ABCG36/PEN3 between the trans-Golgi network and the plasma membrane in root epidermal and cap cells.
Mutagenesis108In act7-8; impaired trafficking and endocytic recycling of ABCG36/PEN3 between the trans-Golgi network and the plasma membrane in root epidermal and cap cells.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 1 variant from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for initiator methionine, modified residue, chain.

Type
IDPosition(s)Description
Initiator methionine1Removed
Modified residue2N-acetylalanine
ChainPRO_00000888922-377Actin-7

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Constitutively expressed at high levels in young expanding vegetative tissues. Also strongly expressed in the hypocotyl and seed coat. Little or no expression is detected in mature pollen sacs, ovules, embryos or seeds.

Induction

Differentially regulated in response to exogenous hormone treatment. In particular, auxin is a strong inducer.

Gene expression databases

Interaction

Subunit

Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. The binding of profilin to monomeric G-actin cause the sequestration of actin into profilactin complexes, and prevents the polymerization.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the actin family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    377
  • Mass (Da)
    41,736
  • Last updated
    1996-10-01 v1
  • MD5 Checksum
    2FFCB53B7D2D14D012C2571879D417C1
MADGEDIQPLVCDNGTGMVKAGFAGDDAPRAVFPSIVGRPRHTGVMVGMGQKDAYVGDEAQSKRGILTLKYPIEHGIVSNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDSLMKILTERGYMFTTTAEREIVRDIKEKLAYVALDYEQELETAKSSSSVEKNYELPDGQVITIGAERFRCPEVLFQPSLIGMEAPGIHETTYNSIMKCDVDIRKDLYGNIVLSGGSTMFPGIADRMSKEITALAPSSMKIKVVAPPERKYSVWIGGSILASLSTFQQMWISKSEYDESGPSIVHRKCF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U37281
EMBL· GenBank· DDBJ
AAA80356.1
EMBL· GenBank· DDBJ
mRNA
U27811
EMBL· GenBank· DDBJ
AAB52506.1
EMBL· GenBank· DDBJ
Genomic DNA
AB016893
EMBL· GenBank· DDBJ
BAB09402.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002688
EMBL· GenBank· DDBJ
AED91450.1
EMBL· GenBank· DDBJ
Genomic DNA
AY062702
EMBL· GenBank· DDBJ
AAL32780.1
EMBL· GenBank· DDBJ
mRNA
AY063980
EMBL· GenBank· DDBJ
AAL36336.1
EMBL· GenBank· DDBJ
mRNA
AY096397
EMBL· GenBank· DDBJ
AAM20037.1
EMBL· GenBank· DDBJ
mRNA
AY114679
EMBL· GenBank· DDBJ
AAM47998.1
EMBL· GenBank· DDBJ
mRNA
AY120779
EMBL· GenBank· DDBJ
AAM53337.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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