P53185 · VIR_YEAST

Function

function

Component of the MIS complex, a complex that mediates N6-methyladenosine (m6A) methylation of meiotic mRNAs and is required for initiation of meiosis, progression through the meiotic divisions and sporulation (PubMed:36930734).
In the complex, performs a scaffolding role stabilizing the other complex members (PubMed:36930734).

Miscellaneous

Present with 486 molecules/cell in log phase SD medium.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentmediator complex
Cellular Componentnucleolus
Cellular ComponentRNA N6-methyladenosine methyltransferase complex
Cellular Componenttranscription regulator complex
Biological Processmeiotic cell cycle
Biological Processpositive regulation of transcription by RNA polymerase II

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein virilizer

Gene names

    • Name
      VIR1
    • Ordered locus names
      YGL036W

Organism names

Accessions

  • Primary accession
    P53185
  • Secondary accessions
    • D6VUA3

Proteomes

Organism-specific databases

Phenotypes & Variants

Disruption phenotype

Severely decreases N6-methyladenosine (m6A) levels following meiotic induction (PubMed:36930734).
Abnormal cell cycle arrest in meiotic interphase before premeiotic DNA replication (PubMed:36930734).
Increases the rate of degradation of KAR4, MUM2 and IME4 protein (PubMed:36930734).
Increases RME1 protein levels, and decreases IME1 transcript levels (PubMed:36930734).
Decreases RNA level of genes involved in translation and ribosome biogenesis, and early meiotic genes (PubMed:36930734).
Partially suppressed by disruption of RME1 (PubMed:36930734).

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 27 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000966131-909Protein virilizer
Modified residue856Phosphoserine
Modified residue898Phosphoserine

Keywords

Proteomic databases

PTM databases

Interaction

Subunit

Component of the MIS (mRNA N6-methyladenosine (m6A) methylation) complex, at least composed of IME4, KAR4, MUM2, SLZ1, and VIR1 (PubMed:36930734).
Interacts with KAR4 (PubMed:36930734).
Interacts with SLZ1 (PubMed:36930734).
Interacts with MUM2 (PubMed:36930734).
Interacts with IME4 (PubMed:36930734).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY P53185MUM2 P382363EBI-11537, EBI-11619

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region746-824Disordered

Sequence similarities

Belongs to the vir family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    909
  • Mass (Da)
    102,371
  • Last updated
    1996-10-01 v1
  • Checksum
    5B1849B0F983175B
MQKCAGHAPLVTAASRVSQDTVDALLQAILKAYHKLASIDSHINDPVEIAFKLINSFKYLPISGSSVKDFESELRELDVFSPLLQSAVTAANNSNIIWDLIAVLFAYISIHKQLHPLILHNLNIWKDFMADNDEETATTTDGDSMNFGVLSLLSIVQNFEEITPNLFEFLKLGLRSTLLKIWVAQWQRYDPSATNLINGDEKISSWITKDYQVDFFIITSLASTSSLEVLPSHYFVYKISKRISHFPNLIDPKLYRSAISTIMENGISDNGGGENSSDKIDPTDLSFHLQVLMEVIDHPELNYLQENRLILLLDIALNYLILVPTHCLHSNFGELGSTQSLASTLNIIQFLLSKFLINMGSISQLINQYNRKCITTNNINNNNINNNGVINGSTNTTSTTTTTITNNNNNSNNSSISNNNRKIDWTQSYQTRYQIPYWFEDSILPPIPPISKSLFTFDKNLDHESDSIMIVNDVLRCLNLTILLISKLLRDYDDLKINPLIQSSDDHSNEDNHVIIEQYMQLYLVPLFTSLLLAQQLKDRGQERDEGHKEKEENINLIGSSSVKKLFSQLIFFSSLKLCENLVIKEKNLALYHLIKFATKVSLDDLILQKISINLLNHLFFHQIRDGSDDDNLIKKLCLKNQLSFQALKDYITLWNDGSEVYNAFYKELFYEEQPKIKPIKLTTSDLLKLFPEDVQFVISTPPNTITSASTSDNCTSSQSAAQKNIENFTTLSKYDVYSSTSFIPSTSKNTNTNVSKQQQQPQNSTPCSSNRFLFNKSSLISQESNGSNNNSGTQGPGSMNESYSLDNSFNTTNTNMTRQPTTLTRATDAMTTAPTTPIPYKNTSGSSNNNLWIESPMTNFKGSTISKSTNKSKMVNTGKNYILGGHNKVKNNSRAQSIHIDDFENENN

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Z72558
EMBL· GenBank· DDBJ
CAA96738.1
EMBL· GenBank· DDBJ
Genomic DNA
Z72557
EMBL· GenBank· DDBJ
CAA96737.1
EMBL· GenBank· DDBJ
Genomic DNA
BK006941
EMBL· GenBank· DDBJ
DAA08064.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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