P53170 · PDK2_YEAST
- Protein[Pyruvate dehydrogenase (acetyl-transferring)] kinase 2, mitochondrial
- GenePKP2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids491 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit (PDA1), thus contributing to the regulation of glucose metabolism.
Miscellaneous
Present with 450 molecules/cell in log phase SD medium.
Catalytic activity
- ATP + L-seryl-[pyruvate dehydrogenase E1 alpha subunit] = ADP + H+ + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit]
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 300-307 | ATP (UniProtKB | ChEBI) | ||||
Sequence: EILRNTYE | ||||||
Binding site | 341 | ATP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 359-360 | ATP (UniProtKB | ChEBI) | ||||
Sequence: SK | ||||||
Binding site | 383-446 | ATP (UniProtKB | ChEBI) | ||||
Sequence: DEVHSHTKYNSKLKSLQSITLKPYMHTSLEPMSYPSIINGHIKYETPLIELLKRSFRYKLGIGL |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial matrix | |
Cellular Component | mitochondrion | |
Molecular Function | ATP binding | |
Molecular Function | protein kinase activity | |
Molecular Function | pyruvate dehydrogenase (acetyl-transferring) kinase activity | |
Biological Process | regulation of glucose metabolic process | |
Biological Process | regulation of mitophagy |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name[Pyruvate dehydrogenase (acetyl-transferring)] kinase 2, mitochondrial
- EC number
- Short namesPDK 2 ; Pyruvate dehydrogenase kinase 2
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionP53170
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain, transit peptide.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000202765 | ?-491 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase 2, mitochondrial | |||
Sequence: MSKYQINCIRYRHFLRTSNISQIPDFTKYCIGPVNEELAPYIMETMKAYPSNSEYINPQHYYHNRTVLVENYLKRSPNPVSLTQLAQYYDDSTKLTRTKIINSGKFVKEELVIRIAHKLNQLQQLPFNVVNNFHFVQVYESYYNIFESFRKYPTIRTLEDASQFADFIKNMLEGFNTLNLPHLIMGALECTILDLYPREKMDQLLSDLLRARISRRLIVEEHVSITANYTSGKEENTLVLGDIFQECSAKKYLLEASEESQKFIQDMYFKDIPMPEFIIEGDTQLSFYFLPTHLKYLLGEILRNTYEATMKHYIRKGLEKPEPIIVTVVSNDESYLFRISDKAGGVLHDDENLWSFGKSKERAQESLNNFHKLPGLQTVSIYDEVHSHTKYNSKLKSLQSITLKPYMHTSLEPMSYPSIINGHIKYETPLIELLKRSFRYKLGIGLAMCKVYAEYWNGDLSLHSMPGYGTDVVLKLGNLMKHTKKLQLDKV | ||||||
Transit peptide | 1-? | Mitochondrion |
Proteomic databases
PTM databases
Interaction
Subunit
Interacts with PKP1.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P53170 | PKP1 P40530 | 4 | EBI-23792, EBI-2610722 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 153-480 | Histidine kinase | ||||
Sequence: PTIRTLEDASQFADFIKNMLEGFNTLNLPHLIMGALECTILDLYPREKMDQLLSDLLRARISRRLIVEEHVSITANYTSGKEENTLVLGDIFQECSAKKYLLEASEESQKFIQDMYFKDIPMPEFIIEGDTQLSFYFLPTHLKYLLGEILRNTYEATMKHYIRKGLEKPEPIIVTVVSNDESYLFRISDKAGGVLHDDENLWSFGKSKERAQESLNNFHKLPGLQTVSIYDEVHSHTKYNSKLKSLQSITLKPYMHTSLEPMSYPSIINGHIKYETPLIELLKRSFRYKLGIGLAMCKVYAEYWNGDLSLHSMPGYGTDVVLKLGNLM |
Sequence similarities
Belongs to the PDK/BCKDK protein kinase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length491
- Mass (Da)57,294
- Last updated2011-09-21 v3
- ChecksumB3218D0207C47ADD
Sequence caution
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 224-225 | in Ref. 1 and 2; CAA96762 | ||||
Sequence: SI → VY |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
Z72581 EMBL· GenBank· DDBJ | CAA96762.1 EMBL· GenBank· DDBJ | Genomic DNA | Frameshift | |
BK006941 EMBL· GenBank· DDBJ | DAA08043.2 EMBL· GenBank· DDBJ | Genomic DNA |