P53170 · PDK2_YEAST

Function

function

Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit (PDA1), thus contributing to the regulation of glucose metabolism.

Miscellaneous

Present with 450 molecules/cell in log phase SD medium.

Catalytic activity

Features

Showing features for binding site.

149150100150200250300350400450
TypeIDPosition(s)Description
Binding site300-307ATP (UniProtKB | ChEBI)
Binding site341ATP (UniProtKB | ChEBI)
Binding site359-360ATP (UniProtKB | ChEBI)
Binding site383-446ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmitochondrial matrix
Cellular Componentmitochondrion
Molecular FunctionATP binding
Molecular Functionprotein kinase activity
Molecular Functionpyruvate dehydrogenase (acetyl-transferring) kinase activity
Biological Processregulation of glucose metabolic process
Biological Processregulation of mitophagy

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    [Pyruvate dehydrogenase (acetyl-transferring)] kinase 2, mitochondrial
  • EC number
  • Short names
    PDK 2
    ; Pyruvate dehydrogenase kinase 2
  • Alternative names
    • Protein kinase of PDH protein 2
    • Pyruvate dehydrogenase complex kinase 2
      (PDC kinase 2
      )
    • [Pyruvate dehydrogenase [lipoamide]] kinase 2

Gene names

    • Name
      PKP2
    • Ordered locus names
      YGL059W

Organism names

Accessions

  • Primary accession
    P53170
  • Secondary accessions
    • D6VU82

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, transit peptide.

TypeIDPosition(s)Description
ChainPRO_0000202765?-491[Pyruvate dehydrogenase (acetyl-transferring)] kinase 2, mitochondrial
Transit peptide1-?Mitochondrion

Proteomic databases

PTM databases

Interaction

Subunit

Interacts with PKP1.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY P53170PKP1 P405304EBI-23792, EBI-2610722

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain153-480Histidine kinase

Sequence similarities

Belongs to the PDK/BCKDK protein kinase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    491
  • Mass (Da)
    57,294
  • Last updated
    2011-09-21 v3
  • Checksum
    B3218D0207C47ADD
MSKYQINCIRYRHFLRTSNISQIPDFTKYCIGPVNEELAPYIMETMKAYPSNSEYINPQHYYHNRTVLVENYLKRSPNPVSLTQLAQYYDDSTKLTRTKIINSGKFVKEELVIRIAHKLNQLQQLPFNVVNNFHFVQVYESYYNIFESFRKYPTIRTLEDASQFADFIKNMLEGFNTLNLPHLIMGALECTILDLYPREKMDQLLSDLLRARISRRLIVEEHVSITANYTSGKEENTLVLGDIFQECSAKKYLLEASEESQKFIQDMYFKDIPMPEFIIEGDTQLSFYFLPTHLKYLLGEILRNTYEATMKHYIRKGLEKPEPIIVTVVSNDESYLFRISDKAGGVLHDDENLWSFGKSKERAQESLNNFHKLPGLQTVSIYDEVHSHTKYNSKLKSLQSITLKPYMHTSLEPMSYPSIINGHIKYETPLIELLKRSFRYKLGIGLAMCKVYAEYWNGDLSLHSMPGYGTDVVLKLGNLMKHTKKLQLDKV

Sequence caution

The sequence CAA96762.1 differs from that shown. Reason: Frameshift

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict224-225in Ref. 1 and 2; CAA96762

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Z72581
EMBL· GenBank· DDBJ
CAA96762.1
EMBL· GenBank· DDBJ
Genomic DNA Frameshift
BK006941
EMBL· GenBank· DDBJ
DAA08043.2
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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