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P53146 · USE1_YEAST

Function

function

SNARE required for targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.

Miscellaneous

Present with 937 molecules/cell in log phase SD medium.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasmic side of endoplasmic reticulum membrane
Cellular Componentendoplasmic reticulum
Cellular ComponentGolgi to ER transport vesicle membrane
Cellular ComponentSNARE complex
Molecular FunctionSNAP receptor activity
Biological Processprotein transport
Biological Processretrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
Biological Processvesicle fusion with endoplasmic reticulum

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein transport protein USE1
  • Alternative names
    • SNARE-like tail-anchored protein 1
    • Unconventional SNARE in the endoplasmic reticulum protein 1

Gene names

    • Name
      USE1
    • Synonyms
      SLT1
    • Ordered locus names
      YGL098W

Organism names

Accessions

  • Primary accession
    P53146
  • Secondary accessions
    • D6VU47

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

Type
IDPosition(s)Description
Topological domain1-218Cytoplasmic
Transmembrane219-239Helical; Anchor for type IV membrane protein
Topological domain240-245Lumenal

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis183In USE1-0; slows down protein transport from the endoplasmic reticulum to the Golgi at 37 degrees Celsius.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 3 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002155841-245Protein transport protein USE1

Proteomic databases

PTM databases

Interaction

Subunit

Component of a SNARE complex consisting of UFE1, USE1, SEC20 and SEC22 or YKT6.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntAct
BINARY P53146SEC20 P287915EBI-23881, EBI-16572
BINARY P53146SEC39 Q127455EBI-23881, EBI-31898
BINARY P53146UFE1 P418343EBI-23881, EBI-20016

Complex viewer

View interactors in UniProtKB
View CPX-5304 in Complex Portal

Protein-protein interaction databases

Miscellaneous

Family & Domains

Sequence similarities

Belongs to the USE1 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    245
  • Mass (Da)
    28,107
  • Last updated
    1996-10-01 v1
  • MD5 Checksum
    0B8DBED3F75EE3B4C2263C9749B8D000
MAETSNDPFLSYVLSSKQLTNLNRLRRKAVTKQLGSSDDNKVSEEFLRYQHTYQREAFEYLQTKHDAHKIMESQYEQYQSSSKTRRYSIDLDSVDAVDTESQTEYPNEEFIDRNEDSEAVMELRKRLLGKGQNKGLGYETTKSVDRQIEDQDTLQQDLIQDMSKLVGSLKQGAVAFQSALDEDKQVLGAAEIGIQVASQGLMDVSGKLRKYDKSKLSYLFYITVFIFMILGLVFTFIIIQLFPAL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Z72620
EMBL· GenBank· DDBJ
CAA96804.1
EMBL· GenBank· DDBJ
Genomic DNA
AY557814
EMBL· GenBank· DDBJ
AAS56140.1
EMBL· GenBank· DDBJ
Genomic DNA
BK006941
EMBL· GenBank· DDBJ
DAA08008.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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