P53094 · MDS3_YEAST
- ProteinNegative regulator of sporulation MDS3
- GeneMDS3
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1487 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Negatively regulates early sporulation-specific genes. Seems to exert its function by positively regulating the Ras/cAMP pathway. Required for growth under alkaline conditions. Acts synergetically with PMD1.
Miscellaneous
Present with 396 molecules/cell in log phase SD medium.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | cytosol | |
Cellular Component | mitochondrion | |
Biological Process | cell redox homeostasis | |
Biological Process | meiotic cell cycle | |
Biological Process | negative regulation of ascospore formation | |
Biological Process | pseudohyphal growth | |
Biological Process | sporulation resulting in formation of a cellular spore | |
Biological Process | TOR signaling |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNegative regulator of sporulation MDS3
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionP53094
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000119137 | 1-1487 | Negative regulator of sporulation MDS3 | |||
Sequence: MPLLQPSTCFCYPLKLPPLPLTSDSNEFDECARKRLTLDYRTGSAVTLTRSNIFVHGGLTIPLNLPVVNSMQLQKELILFFAKEKNNGSSFRNLNEWISKETFFLDLMSRTWYRVKTSFDQRTEELLKAESSSAKADNDTNEIRTDIKKGKSLESPLKERLFHSLCYLDGCLYIFGGLTVSPQSGYELIATNELWKLDLNTKKWSLLSDDPQIARRFNHTMHVKNENNDNRDTKLIIVGGLNNMDQPVKKIDIYNISQNCWQSETIPKQPMEITTNVNGIPLALSKDQNFSILVENNEANVPALAFYMRSDQIDEYLGKDSSKIKENSPIVALPLLSESQGIRMPSNPALPKKLLNVPYELLAPTGDYFGFNIIIGGFHPNYQSSNFHCFIYDINSGKWSRVATACPDCDINKHRFWRVFVWKSHHQTILLGTKTDDYYSPSVQRFDHLSTFGLPLVNIFNKTIQLPHHKISASSLPIPIENFAKHKDTPLKKVSFTSSATSQFENYIRYIAPPLEMSSIQSVFPPYAMVLGKDALEIYGKPLSDFEFITSEGDSIGIPCYLLRKRWGRYFDMLLSQSYTKVCADYETTDTQSTLIKFSPHSSRNSSKAVRQEGRLSSSGSLDNYFEKNFPIFARTSVSEAQNTQPQVANADAKAPNTPSTSDEPSSSSSSDLYSTPHYQRNNDEEDDEDPVSPKPVSKSNSIYRPIRKTESSSTTSSSNGMIFRVPFKEKAAVTSNTEALLESNLSLQELSRRRSSLMSIPSGELLRSSISEAEHQRRASHPLTSSPLFEDSGTPCGKQLQQLQQHTIQNPHNHLSPRRFSRSARSSISYVSSSSDRRGNSISSRSTSDSFGTPPVLGVLNVPLPPQTREPNEPPPPCPAMSTGSNTRRSNTLTDYMHSNKASPFSSRRSSHIGRRSSTPETENAFSATPRASLDGQMLGKSLKEGSTSQYTQPRMNSFPKANETIQTPTSSNNEWSRQSVTSNTDSFDSLQSNFALELEPLLTPRSLYMPWPTSTVRAFAEFFYTGQVNSKWLLAPVALDLLVMAKIYEIPLLYKLILEVLYSILAKKEESLSLICTSLMETFRTKTLNSYKGDEEKTNTYLTSNDNYQELLKLKVSLENIDNGYYDPDLLRKQSRAQSSSTQESSGSANGEKTATGAGSLETSSTNVPTVFAGGPRDSHNSVGSIGFPNSMNIQGSRRSTSGFSPRVKMKSSLSKEIDPKTFYEEYEPKEGKSFDDNDDQQTNIGSFNLHLFDMNYGSISSSSTNSISSSDLEEKEEQEQLQDLLEIEREDSAEILDARFRNKEDDKVTKDISNDKKRNYLPHEKNNLKAKEGKETRDVREEEEEFDFGLGMLSLNKIKREAKHVDKVDDSVDPLFKSSAFPQSPIRAYGSTTRTSSASGKPFRDNRSFNAFSVLTLENMASANALPPVDYVIKSIYRTTVLVNDIRLMVRCMDCIELSKNLRALKKKTMEDISKLKGISKPSP | ||||||
Modified residue | 472 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 475 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 621 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 639 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 693 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 698 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 744 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 747 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 756 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 757 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 781 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 785 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 787 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 900 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 904 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 930 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 1187 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P53094 | CDC25 P04821 | 3 | EBI-10651, EBI-4237 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for repeat, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 171-226 | Kelch 1 | ||||
Sequence: CLYIFGGLTVSPQSGYELIATNELWKLDLNTKKWSLLSDDPQIARRFNHTMHVKNE | ||||||
Repeat | 234-287 | Kelch 2 | ||||
Sequence: KLIIVGGLNNMDQPVKKIDIYNISQNCWQSETIPKQPMEITTNVNGIPLALSKD | ||||||
Repeat | 371-419 | Kelch 3 | ||||
Sequence: FNIIIGGFHPNYQSSNFHCFIYDINSGKWSRVATACPDCDINKHRFWRV | ||||||
Compositional bias | 639-678 | Polar residues | ||||
Sequence: SEAQNTQPQVANADAKAPNTPSTSDEPSSSSSSDLYSTPH | ||||||
Region | 639-720 | Disordered | ||||
Sequence: SEAQNTQPQVANADAKAPNTPSTSDEPSSSSSSDLYSTPHYQRNNDEEDDEDPVSPKPVSKSNSIYRPIRKTESSSTTSSSN | ||||||
Compositional bias | 695-720 | Polar residues | ||||
Sequence: KPVSKSNSIYRPIRKTESSSTTSSSN | ||||||
Region | 772-796 | Disordered | ||||
Sequence: SEAEHQRRASHPLTSSPLFEDSGTP | ||||||
Compositional bias | 781-796 | Polar residues | ||||
Sequence: SHPLTSSPLFEDSGTP | ||||||
Compositional bias | 810-855 | Polar residues | ||||
Sequence: QNPHNHLSPRRFSRSARSSISYVSSSSDRRGNSISSRSTSDSFGTP | ||||||
Region | 810-986 | Disordered | ||||
Sequence: QNPHNHLSPRRFSRSARSSISYVSSSSDRRGNSISSRSTSDSFGTPPVLGVLNVPLPPQTREPNEPPPPCPAMSTGSNTRRSNTLTDYMHSNKASPFSSRRSSHIGRRSSTPETENAFSATPRASLDGQMLGKSLKEGSTSQYTQPRMNSFPKANETIQTPTSSNNEWSRQSVTSNT | ||||||
Compositional bias | 868-882 | Pro residues | ||||
Sequence: QTREPNEPPPPCPAM | ||||||
Compositional bias | 883-932 | Polar residues | ||||
Sequence: STGSNTRRSNTLTDYMHSNKASPFSSRRSSHIGRRSSTPETENAFSATPR | ||||||
Compositional bias | 943-986 | Polar residues | ||||
Sequence: SLKEGSTSQYTQPRMNSFPKANETIQTPTSSNNEWSRQSVTSNT | ||||||
Region | 1134-1169 | Disordered | ||||
Sequence: RKQSRAQSSSTQESSGSANGEKTATGAGSLETSSTN | ||||||
Compositional bias | 1135-1169 | Polar residues | ||||
Sequence: KQSRAQSSSTQESSGSANGEKTATGAGSLETSSTN | ||||||
Compositional bias | 1189-1211 | Polar residues | ||||
Sequence: GFPNSMNIQGSRRSTSGFSPRVK | ||||||
Region | 1189-1214 | Disordered | ||||
Sequence: GFPNSMNIQGSRRSTSGFSPRVKMKS | ||||||
Region | 1263-1283 | Disordered | ||||
Sequence: SSSSTNSISSSDLEEKEEQEQ | ||||||
Region | 1308-1341 | Disordered | ||||
Sequence: DDKVTKDISNDKKRNYLPHEKNNLKAKEGKETRD |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,487
- Mass (Da)166,971
- Last updated2011-09-21 v2
- Checksum31073D68ACA4AF61
Features
Showing features for sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 262-264 | in Ref. 1; CAA62947 and 2; CAA96909 | ||||
Sequence: QSE → HPK | ||||||
Sequence conflict | 403 | in Ref. 1; CAA62947 and 2; CAA96909 | ||||
Sequence: A → R | ||||||
Compositional bias | 639-678 | Polar residues | ||||
Sequence: SEAQNTQPQVANADAKAPNTPSTSDEPSSSSSSDLYSTPH | ||||||
Compositional bias | 695-720 | Polar residues | ||||
Sequence: KPVSKSNSIYRPIRKTESSSTTSSSN | ||||||
Compositional bias | 781-796 | Polar residues | ||||
Sequence: SHPLTSSPLFEDSGTP | ||||||
Compositional bias | 810-855 | Polar residues | ||||
Sequence: QNPHNHLSPRRFSRSARSSISYVSSSSDRRGNSISSRSTSDSFGTP | ||||||
Compositional bias | 868-882 | Pro residues | ||||
Sequence: QTREPNEPPPPCPAM | ||||||
Compositional bias | 883-932 | Polar residues | ||||
Sequence: STGSNTRRSNTLTDYMHSNKASPFSSRRSSHIGRRSSTPETENAFSATPR | ||||||
Compositional bias | 943-986 | Polar residues | ||||
Sequence: SLKEGSTSQYTQPRMNSFPKANETIQTPTSSNNEWSRQSVTSNT | ||||||
Compositional bias | 1135-1169 | Polar residues | ||||
Sequence: KQSRAQSSSTQESSGSANGEKTATGAGSLETSSTN | ||||||
Compositional bias | 1189-1211 | Polar residues | ||||
Sequence: GFPNSMNIQGSRRSTSGFSPRVK |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X91837 EMBL· GenBank· DDBJ | CAA62947.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z72719 EMBL· GenBank· DDBJ | CAA96909.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BK006941 EMBL· GenBank· DDBJ | DAA07917.2 EMBL· GenBank· DDBJ | Genomic DNA |