P53044 · UFD1_YEAST

Function

function

Functions at a post-ubiquitation step in the ubiquitin fusion degradation (UFD) pathway. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway. Required for the proteasome-dependent processing/activation of MGA2 and SPT23 transcription factors leading to the subsequent expression of OLE1. Has an additional role in the turnover of OLE1 where it targets ubiquitinated OLE1 and other proteins to the ERAD.

Miscellaneous

Present with 3530 molecules/cell in log phase SD medium.

Features

Showing features for site.

136150100150200250300350
TypeIDPosition(s)Description
Site37Monoubiquitin-binding
Site39Monoubiquitin-binding
Site109Monoubiquitin-binding

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular ComponentDoa10p ubiquitin ligase complex
Cellular ComponentHrd1p ubiquitin ligase ERAD-L complex
Cellular Componentnucleus
Cellular Componentreplisome
Cellular ComponentRQC complex
Cellular ComponentVCP-NPL4-UFD1 AAA ATPase complex
Molecular Functionpolyubiquitin modification-dependent protein binding
Molecular Functionubiquitin binding
Biological Processcytoplasm protein quality control by the ubiquitin-proteasome system
Biological ProcessDNA replication termination
Biological ProcessERAD pathway
Biological Processmitochondria-associated ubiquitin-dependent protein catabolic process
Biological Processnonfunctional rRNA decay
Biological Processpositive regulation of protein localization to nucleus
Biological Processproteasome-mediated ubiquitin-dependent protein catabolic process
Biological Processprotein localization to vacuole
Biological Processrescue of stalled ribosome
Biological Processretrograde protein transport, ER to cytosol
Biological Processribosome-associated ubiquitin-dependent protein catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ubiquitin fusion degradation protein 1
  • Short names
    UB fusion protein 1
  • Alternative names
    • Polymerase-interacting protein 3

Gene names

    • Name
      UFD1
    • Synonyms
      PIP3
    • Ordered locus names
      YGR048W

Organism names

Accessions

  • Primary accession
    P53044
  • Secondary accessions
    • D6VUI5
    • Q45U36

Proteomes

Organism-specific databases

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis94In UFD1-1; grows more slowly.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 3 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00001949891-361Ubiquitin fusion degradation protein 1
Modified residue354Phosphoserine

Keywords

Proteomic databases

PTM databases

Interaction

Subunit

Component of the heterotrimeric CDC48-NPL4-UFD1 ATPase complex (PubMed:16873066).
The CDC48-NPL4-UFD1 ATPase complex interacts with the HRD1 ubiquitin ligase complex composed of the E3 ligase HRD1, its cofactors HRD3, USA1 and DER1, substrate recruiting factor YOS9 and CDC48-binding protein UBX2 (PubMed:16873066).
Interaction between the complexes is mediated by interaction between CDC48-NPL4-UFD1 complex member CDC48 and HRD1 complex member UBX2 (PubMed:16873066).
Forms a complex composed of CDC48, NPL4, UFD1, DOA1, SHP1 and deubiquitinase OTU1 (PubMed:16427015).
Interacts with NPL4, CDC48 and UBX2 (PubMed:11598205, PubMed:11733065, PubMed:16873066).

Binary interactions

View interactors in UniProtKB
View CPX-2946 in Complex Portal

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region27-28Monoubiquitin-binding
Region30-32Monoubiquitin-binding
Region99-101Monoubiquitin-binding
Region310-361Disordered
Compositional bias318-333Polar residues
Compositional bias336-361Basic and acidic residues

Sequence similarities

Belongs to the UFD1 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    361
  • Mass (Da)
    39,810
  • Last updated
    1996-10-01 v1
  • Checksum
    198E0CD48B863B98
MFSGFSSFGGGNGFVNMPQTFEEFFRCYPIAMMNDRIRKDDANFGGKIFLPPSALSKLSMLNIRYPMLFKLTANETGRVTHGGVLEFIAEEGRVYLPQWMMETLGIQPGSLLQISSTDVPLGQFVKLEPQSVDFLDISDPKAVLENVLRNFSTLTVDDVIEISYNGKTFKIKILEVKPESSSKSICVIETDLVTDFAPPVGYVEPDYKALKAQQDKEKKNSFGKGQVLDPSVLGQGSMSTRIDYAGIANSSRNKLSKFVGQGQNISGKAPKAEPKQDIKDMKITFDGEPAKLDLPEGQLFFGFPMVLPKEDEESAAGSKSSEQNFQGQGISLRKSNKRKTKSDHDSSKSKAPKSPEVIEID

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias318-333Polar residues
Compositional bias336-361Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U22153
EMBL· GenBank· DDBJ
AAC49023.1
EMBL· GenBank· DDBJ
Genomic DNA
U17264
EMBL· GenBank· DDBJ
AAB46627.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ115391
EMBL· GenBank· DDBJ
AAZ22463.1
EMBL· GenBank· DDBJ
Genomic DNA
Z72833
EMBL· GenBank· DDBJ
CAA97047.1
EMBL· GenBank· DDBJ
Genomic DNA
AY692806
EMBL· GenBank· DDBJ
AAT92825.1
EMBL· GenBank· DDBJ
Genomic DNA
BK006941
EMBL· GenBank· DDBJ
DAA08146.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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