P53032 · SUT1_YEAST
- ProteinSterol uptake protein 1
- GeneSUT1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids299 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Transcription factor involved in the induction of hypoxic gene transcription when the cells are shifted from aerobiosis to anaerobiosis (PubMed:11248676, PubMed:11401714, PubMed:15035656).
Promotes exogenous sterol uptake and stimulates endogenous sterol biosynthesis (PubMed:11248676, PubMed:11401714, PubMed:12435498, PubMed:7489925).
With SUT2, positively regulates mating by repressing the expression of the mating inhibitors NCE102, PRR2 and RHO5 in response to pheromone (PubMed:23872066).
Finally, regulates filamentation via the repression of genes such as GAT2, HAP4, MGA1, MSN4, NCE102, PRR2, RHO3, and RHO5, when nutrients are plentifu (PubMed:23223039).
Promotes exogenous sterol uptake and stimulates endogenous sterol biosynthesis (PubMed:11248676, PubMed:11401714, PubMed:12435498, PubMed:7489925).
With SUT2, positively regulates mating by repressing the expression of the mating inhibitors NCE102, PRR2 and RHO5 in response to pheromone (PubMed:23872066).
Finally, regulates filamentation via the repression of genes such as GAT2, HAP4, MGA1, MSN4, NCE102, PRR2, RHO3, and RHO5, when nutrients are plentifu (PubMed:23223039).
Miscellaneous
Present with 1100 molecules/cell in log phase SD medium.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
Molecular Function | RNA polymerase II-specific DNA-binding transcription factor binding | |
Molecular Function | zinc ion binding | |
Biological Process | cellular response to starvation | |
Biological Process | negative regulation of filamentous growth of a population of unicellular organisms | |
Biological Process | negative regulation of transcription by RNA polymerase II | |
Biological Process | positive regulation of induction of conjugation with cellular fusion | |
Biological Process | positive regulation of sterol import | |
Biological Process | positive regulation of transcription by RNA polymerase II |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSterol uptake protein 1
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionP53032
- Secondary accessions
Proteomes
Organism-specific databases
Phenotypes & Variants
Disruption phenotype
Leads to increased expression of NCE102 and PRR2, when SUT2 is also deleted.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 13 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000115014 | 1-299 | Sterol uptake protein 1 | |||
Sequence: MSTSITVRNRDRSLPPLLLPNVSLLEKDIRRKGTQNVGITDPELLSTTWTRKRAFPTDELLGGYKRLKPAAADSNECAIGIATVTPPPTLPVSAIVPPPQNYTPPLFEYHPHALASMVNEDANASCTQMSIISRSTSNSTTSSATSTSSISKRQRSGPSCDKCRLKKIKCNAKIEILLQDDTIMPMISNKLRYVLTPDDIRLYRGTLLRNIAIPDDVIEGTGSRKLIKHIDKLVLLTPCLPCIKKKHSSSSTNFPKNDKCTFSKGFTRADINISSKISLKFKDKTIYDITYDDYKSIDF |
Proteomic databases
PTM databases
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 133-156 | Polar residues | ||||
Sequence: SRSTSNSTTSSATSTSSISKRQRS | ||||||
Region | 133-160 | Disordered | ||||
Sequence: SRSTSNSTTSSATSTSSISKRQRSGPSC |
Sequence similarities
Belongs to the SUT1 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length299
- Mass (Da)33,191
- Last updated1996-10-01 v1
- ChecksumA77B0B506177586D
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 133-156 | Polar residues | ||||
Sequence: SRSTSNSTTSSATSTSSISKRQRS |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X77766 EMBL· GenBank· DDBJ | CAA54806.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z48618 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
Z72684 EMBL· GenBank· DDBJ | CAA96874.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BK006941 EMBL· GenBank· DDBJ | DAA07950.1 EMBL· GenBank· DDBJ | Genomic DNA |