circRERE regulates the expression of GBX2 through miR-1299 and ZC3H13/N(6)-methyladenosine (m(6)A) to promote growth and invasion of hepatocellular carcinoma cells.
Gastrulation brain homeobox 2 (GBX2) methylation is associated with Gleason score (GS) pathologic stage (pT) and biochemical recurrence (BCR) in prostate cancer (PCa). Among intraductal carcinoma/cribriform architecture (IDC/C)-negative patients GBX2 methylation improves prediction of BCR. Loss of TET2 in prostate cells results in greater GBX2 methylation.
Data established a seven-gene (AR ESR2 GATA3 GBX2 KRT16 MMP28 and WNT11) prognostic signature to define a subset of triple-negative breast cancer (TNBC).
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